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Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities.

De D, Chatterjee K, Ali KM, Bera TK, Ghosh D - Evid Based Complement Alternat Med (2010)

Bottom Line: Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver.Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model.Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Medical Laboratory Science and Management, (U.G.C Innovative Department), Vidyasagar University, Midnapore 721 102, West Bengal, India.

ABSTRACT
Antidiabetic, antioxidative, and antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni (L.) Jacq. (family Meliaceae) seed studied in streptozotocin-induced diabetic rats. Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver. Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model. Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model. The results indicated the potentiality of the extract of S. mahagoni seed for the correction of diabetes and its related complications like oxidative stress and hyperlipidemia. The extract may be a good candidate for developing a safety, tolerable, and promising neutraceutical treatment for the management of diabetes.

No MeSH data available.


Related in: MedlinePlus

Correction in the levels of total cholesterol and triglyceride in serum after treatment of aqueous-methanolic extract of S. mahagoni seed in STZ-induced diabetic male albino rat. Bar are expressed as Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
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fig5: Correction in the levels of total cholesterol and triglyceride in serum after treatment of aqueous-methanolic extract of S. mahagoni seed in STZ-induced diabetic male albino rat. Bar are expressed as Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.

Mentions: Serum total cholesterol (TC) and triglyceride (TG) levels were significantly elevated in the diabetic control group in comparison with the control group. After treatment with the above-mentioned extract to the diabetic animals, serum TC and TG levels were recovered significantly towards the control level (Figure 5).


Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities.

De D, Chatterjee K, Ali KM, Bera TK, Ghosh D - Evid Based Complement Alternat Med (2010)

Correction in the levels of total cholesterol and triglyceride in serum after treatment of aqueous-methanolic extract of S. mahagoni seed in STZ-induced diabetic male albino rat. Bar are expressed as Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2958602&req=5

fig5: Correction in the levels of total cholesterol and triglyceride in serum after treatment of aqueous-methanolic extract of S. mahagoni seed in STZ-induced diabetic male albino rat. Bar are expressed as Mean ± S.E.M; n = 6. ANOVA followed by multiple comparison two-tail “t”-test. Bars with different superscripts (a,b,c) differ from each other significantly, P < .05.
Mentions: Serum total cholesterol (TC) and triglyceride (TG) levels were significantly elevated in the diabetic control group in comparison with the control group. After treatment with the above-mentioned extract to the diabetic animals, serum TC and TG levels were recovered significantly towards the control level (Figure 5).

Bottom Line: Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver.Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model.Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Medical Laboratory Science and Management, (U.G.C Innovative Department), Vidyasagar University, Midnapore 721 102, West Bengal, India.

ABSTRACT
Antidiabetic, antioxidative, and antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni (L.) Jacq. (family Meliaceae) seed studied in streptozotocin-induced diabetic rats. Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver. Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model. Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model. The results indicated the potentiality of the extract of S. mahagoni seed for the correction of diabetes and its related complications like oxidative stress and hyperlipidemia. The extract may be a good candidate for developing a safety, tolerable, and promising neutraceutical treatment for the management of diabetes.

No MeSH data available.


Related in: MedlinePlus