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The effect of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat.

Mac Grory B, O'Connor ET, O'Halloran KD, Jones JF - Respir Physiol Neurobiol (2010)

Bottom Line: Twenty-three successful single fibre recordings were obtained from 10 animals.IL-1 beta and TNF-alpha had no statistically significant effect on the frequency of action potentials observed (p=0.39 and 0.42, respectively, repeated measures ANOVA).In conclusion, an immune role for SLN paraganglia has not been established.

View Article: PubMed Central - PubMed

Affiliation: School of Medicine and Medical Science, Health Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland.

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Related in: MedlinePlus

A representative experiment illustrating the effect of IL-1β on action potential frequency in the SLN. The bottom reading is a raw, digitised recording. The top trace illustrates the mean action potential frequency of a single unit (averaged over 10 s) and is derived from the raw recording. This graph is typical of the cytokine group of experiments. Application of increasing concentrations (low to high) of IL-1β does not alter the firing frequency of the SLN. The vigorous response to sodium cyanide (CN) elicited at the end of the protocol confirms the responsivity of the preparation.
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fig5: A representative experiment illustrating the effect of IL-1β on action potential frequency in the SLN. The bottom reading is a raw, digitised recording. The top trace illustrates the mean action potential frequency of a single unit (averaged over 10 s) and is derived from the raw recording. This graph is typical of the cytokine group of experiments. Application of increasing concentrations (low to high) of IL-1β does not alter the firing frequency of the SLN. The vigorous response to sodium cyanide (CN) elicited at the end of the protocol confirms the responsivity of the preparation.


The effect of pro-inflammatory cytokines on the discharge rate of vagal nerve paraganglia in the rat.

Mac Grory B, O'Connor ET, O'Halloran KD, Jones JF - Respir Physiol Neurobiol (2010)

A representative experiment illustrating the effect of IL-1β on action potential frequency in the SLN. The bottom reading is a raw, digitised recording. The top trace illustrates the mean action potential frequency of a single unit (averaged over 10 s) and is derived from the raw recording. This graph is typical of the cytokine group of experiments. Application of increasing concentrations (low to high) of IL-1β does not alter the firing frequency of the SLN. The vigorous response to sodium cyanide (CN) elicited at the end of the protocol confirms the responsivity of the preparation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2958315&req=5

fig5: A representative experiment illustrating the effect of IL-1β on action potential frequency in the SLN. The bottom reading is a raw, digitised recording. The top trace illustrates the mean action potential frequency of a single unit (averaged over 10 s) and is derived from the raw recording. This graph is typical of the cytokine group of experiments. Application of increasing concentrations (low to high) of IL-1β does not alter the firing frequency of the SLN. The vigorous response to sodium cyanide (CN) elicited at the end of the protocol confirms the responsivity of the preparation.
Bottom Line: Twenty-three successful single fibre recordings were obtained from 10 animals.IL-1 beta and TNF-alpha had no statistically significant effect on the frequency of action potentials observed (p=0.39 and 0.42, respectively, repeated measures ANOVA).In conclusion, an immune role for SLN paraganglia has not been established.

View Article: PubMed Central - PubMed

Affiliation: School of Medicine and Medical Science, Health Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland.

Show MeSH
Related in: MedlinePlus