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High resolution multimodal clinical ophthalmic imaging system.

Mujat M, Ferguson RD, Patel AH, Iftimia N, Lue N, Hammer DX - Opt Express (2010)

Bottom Line: The SSOCT channel operates at a wavelength of 1 microm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD.This AO system is designed for use in clinical populations; a dual deformable mirror (DM) configuration allows simultaneous low- and high-order aberration correction over a large range of refractions and ocular media quality.We were able to resolve and quantify cone photoreceptors across the macula to within approximately 0.5 deg (approximately 100-150 microm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve features deep into the choroid.

View Article: PubMed Central - PubMed

Affiliation: Physical Sciences Inc., 20 New England Business Center, Andover MA 01810, USA. mujat@psicorp.com

ABSTRACT
We developed a multimodal adaptive optics (AO) retinal imager which is the first to combine high performance AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. Such systems are becoming ever more essential to vision research and are expected to prove their clinical value for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa. The SSOCT channel operates at a wavelength of 1 microm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD. This AO system is designed for use in clinical populations; a dual deformable mirror (DM) configuration allows simultaneous low- and high-order aberration correction over a large range of refractions and ocular media quality. The system also includes a wide field (33 deg.) line scanning ophthalmoscope (LSO) for initial screening, target identification, and global orientation, an integrated retinal tracker (RT) to stabilize the SLO, OCT, and LSO imaging fields in the presence of lateral eye motion, and a high-resolution LCD-based fixation target for presentation of visual cues. The system was tested in human subjects without retinal disease for performance optimization and validation. We were able to resolve and quantify cone photoreceptors across the macula to within approximately 0.5 deg (approximately 100-150 microm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve features deep into the choroid. The prototype presented here is the first of a new class of powerful flexible imaging platforms that will provide clinicians and researchers with high-resolution, high performance adaptive optics imaging to help guide therapies, develop new drugs, and improve patient outcomes.

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Related in: MedlinePlus

AO performance in a human eye. (a)-(c) Wavefront error map and (d)-(e) point spread function for no AO correction, single DM, and dual DM correction. (g) Time course of AO correction. (h) RMS error by Zernike order.
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g005: AO performance in a human eye. (a)-(c) Wavefront error map and (d)-(e) point spread function for no AO correction, single DM, and dual DM correction. (g) Time course of AO correction. (h) RMS error by Zernike order.

Mentions: An example of the AO performance achieved in one human subject is shown in Fig. 5Fig. 5


High resolution multimodal clinical ophthalmic imaging system.

Mujat M, Ferguson RD, Patel AH, Iftimia N, Lue N, Hammer DX - Opt Express (2010)

AO performance in a human eye. (a)-(c) Wavefront error map and (d)-(e) point spread function for no AO correction, single DM, and dual DM correction. (g) Time course of AO correction. (h) RMS error by Zernike order.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2958093&req=5

g005: AO performance in a human eye. (a)-(c) Wavefront error map and (d)-(e) point spread function for no AO correction, single DM, and dual DM correction. (g) Time course of AO correction. (h) RMS error by Zernike order.
Mentions: An example of the AO performance achieved in one human subject is shown in Fig. 5Fig. 5

Bottom Line: The SSOCT channel operates at a wavelength of 1 microm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD.This AO system is designed for use in clinical populations; a dual deformable mirror (DM) configuration allows simultaneous low- and high-order aberration correction over a large range of refractions and ocular media quality.We were able to resolve and quantify cone photoreceptors across the macula to within approximately 0.5 deg (approximately 100-150 microm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve features deep into the choroid.

View Article: PubMed Central - PubMed

Affiliation: Physical Sciences Inc., 20 New England Business Center, Andover MA 01810, USA. mujat@psicorp.com

ABSTRACT
We developed a multimodal adaptive optics (AO) retinal imager which is the first to combine high performance AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. Such systems are becoming ever more essential to vision research and are expected to prove their clinical value for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa. The SSOCT channel operates at a wavelength of 1 microm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD. This AO system is designed for use in clinical populations; a dual deformable mirror (DM) configuration allows simultaneous low- and high-order aberration correction over a large range of refractions and ocular media quality. The system also includes a wide field (33 deg.) line scanning ophthalmoscope (LSO) for initial screening, target identification, and global orientation, an integrated retinal tracker (RT) to stabilize the SLO, OCT, and LSO imaging fields in the presence of lateral eye motion, and a high-resolution LCD-based fixation target for presentation of visual cues. The system was tested in human subjects without retinal disease for performance optimization and validation. We were able to resolve and quantify cone photoreceptors across the macula to within approximately 0.5 deg (approximately 100-150 microm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve features deep into the choroid. The prototype presented here is the first of a new class of powerful flexible imaging platforms that will provide clinicians and researchers with high-resolution, high performance adaptive optics imaging to help guide therapies, develop new drugs, and improve patient outcomes.

Show MeSH
Related in: MedlinePlus