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Perinatal pandemic (H1N1) 2009 infection, Thailand.

Dulyachai W, Makkoch J, Rianthavorn P, Changpinyo M, Prayangprecha S, Payungporn S, Tantilertcharoen R, Kitikoon P, Poovorawan Y - Emerging Infect. Dis. (2010)

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: Infection with influenza A pandemic (H1N1) 2009 has been reported worldwide following initial identification of the virus in April 2009... The relevant perinatal history was maternal illness with pandemic (H1N1) 2009 7 days before delivery... Oxygen saturation at room air was 91%–99%... Other results of the physical examination were unremarkable... On the basis of the perinatal history, a throat swab specimen was collected for pandemic (H1N1) 2009 testing by PCR and oseltamivir, 6 mg, was administered every 12 hours (4 mg/kg/day)... At day 4 of life, repeated PCR performed on a throat swab specimen was negative for pandemic (H1N1) 2009... Oxygen supplementation was gradually decreased and finally discontinued... Her room air oxygen saturation was 95%–98%... Her clinical symptoms gradually improved... The antimicrobial drugs were given over an 8-day course... Plasma creatinine decreased to 0.9 mg/dL and 0.6 mg/dL at days 6 and 7 of life, respectively... Pregnant women are one of the highest risk groups for influenza A infection and influenza-associated complications, including increased maternal and perinatal illness and death rates... However, kidney function of the mother of the newborn was within normal limits at the time of cesarean section; plasma creatinine level of 0.7 mg/dL... An elevated plasma creatinine level is observed frequently in premature infants due to immaturity of the kidney tissue and will usually decrease within a few weeks... The success of our management strategy for this case suggests early treatment with oseltamivir can prevent severe illness in newborns with perinatal influenza A pandemic (H1N1) 2009 infection.

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Antibody titer against influenza A pandemic (H1N1) 2009 by hemagglutination inhibition (HI) test on days 10, 24, and 42 of life of the patient.
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Figure 1: Antibody titer against influenza A pandemic (H1N1) 2009 by hemagglutination inhibition (HI) test on days 10, 24, and 42 of life of the patient.

Mentions: Infection of the patient was confirmed by real-time reverse transcription–PCR of the throat swab specimen and by a 4× increase in antibodies against the virus by hemagglutination inhibition test (HI). Antibody titers against pandemic influenza (H1N1) 2009 by HI with turkey erythrocytes (4) on days 10, 24, and 42 of life were 10, 160, and 320, respectively (Figure). At day 4 of life, repeated PCR performed on a throat swab specimen was negative for pandemic (H1N1) 2009. Oxygen supplementation was gradually decreased and finally discontinued. Her room air oxygen saturation was 95%–98%. Her clinical symptoms gradually improved. Hemoculture was negative after 72 hours. The antimicrobial drugs were given over an 8-day course. Plasma creatinine decreased to 0.9 mg/dL and 0.6 mg/dL at days 6 and 7 of life, respectively. Her average urine output was 2–3 mL/kg/h. She was discharged at the age of 28 days with a body weight of 2,070 grams.


Perinatal pandemic (H1N1) 2009 infection, Thailand.

Dulyachai W, Makkoch J, Rianthavorn P, Changpinyo M, Prayangprecha S, Payungporn S, Tantilertcharoen R, Kitikoon P, Poovorawan Y - Emerging Infect. Dis. (2010)

Antibody titer against influenza A pandemic (H1N1) 2009 by hemagglutination inhibition (HI) test on days 10, 24, and 42 of life of the patient.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2958034&req=5

Figure 1: Antibody titer against influenza A pandemic (H1N1) 2009 by hemagglutination inhibition (HI) test on days 10, 24, and 42 of life of the patient.
Mentions: Infection of the patient was confirmed by real-time reverse transcription–PCR of the throat swab specimen and by a 4× increase in antibodies against the virus by hemagglutination inhibition test (HI). Antibody titers against pandemic influenza (H1N1) 2009 by HI with turkey erythrocytes (4) on days 10, 24, and 42 of life were 10, 160, and 320, respectively (Figure). At day 4 of life, repeated PCR performed on a throat swab specimen was negative for pandemic (H1N1) 2009. Oxygen supplementation was gradually decreased and finally discontinued. Her room air oxygen saturation was 95%–98%. Her clinical symptoms gradually improved. Hemoculture was negative after 72 hours. The antimicrobial drugs were given over an 8-day course. Plasma creatinine decreased to 0.9 mg/dL and 0.6 mg/dL at days 6 and 7 of life, respectively. Her average urine output was 2–3 mL/kg/h. She was discharged at the age of 28 days with a body weight of 2,070 grams.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

: Infection with influenza A pandemic (H1N1) 2009 has been reported worldwide following initial identification of the virus in April 2009... The relevant perinatal history was maternal illness with pandemic (H1N1) 2009 7 days before delivery... Oxygen saturation at room air was 91%–99%... Other results of the physical examination were unremarkable... On the basis of the perinatal history, a throat swab specimen was collected for pandemic (H1N1) 2009 testing by PCR and oseltamivir, 6 mg, was administered every 12 hours (4 mg/kg/day)... At day 4 of life, repeated PCR performed on a throat swab specimen was negative for pandemic (H1N1) 2009... Oxygen supplementation was gradually decreased and finally discontinued... Her room air oxygen saturation was 95%–98%... Her clinical symptoms gradually improved... The antimicrobial drugs were given over an 8-day course... Plasma creatinine decreased to 0.9 mg/dL and 0.6 mg/dL at days 6 and 7 of life, respectively... Pregnant women are one of the highest risk groups for influenza A infection and influenza-associated complications, including increased maternal and perinatal illness and death rates... However, kidney function of the mother of the newborn was within normal limits at the time of cesarean section; plasma creatinine level of 0.7 mg/dL... An elevated plasma creatinine level is observed frequently in premature infants due to immaturity of the kidney tissue and will usually decrease within a few weeks... The success of our management strategy for this case suggests early treatment with oseltamivir can prevent severe illness in newborns with perinatal influenza A pandemic (H1N1) 2009 infection.

Show MeSH
Related in: MedlinePlus