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Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007.

Galanis E, Macdougall L, Kidd S, Morshed M, British Columbia Cryptococcus gattii Working Gro - Emerging Infect. Dis. (2010)

Bottom Line: The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain.Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains.Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.

View Article: PubMed Central - PubMed

Affiliation: British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada. eleni.galanis@bccdc.ca

ABSTRACT
British Columbia, Canada, has the largest reported population of Cryptococcus gattii-infected persons worldwide. To assess the impact of illness, we retrospectively analyzed demographic and clinical features of reported cases, hospitalizations, and deaths during 1999-2007. A total of 218 cases were reported (average annual incidence 5.8 per million persons). Most persons who sought treatment had respiratory illness (76.6%) or lung cryptococcoma (75.4%). Persons without HIV/AIDS hospitalized with cryptococcosis were more likely than those with HIV/AIDS to be older and admitted for pulmonary cryptococcosis. The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain. Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains. Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.

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Distribution of Cryptococcus gattii strains among 124 persons with C. gattii infection, by age category, British Columbia, Canada, 1999–2007.
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Figure 2: Distribution of Cryptococcus gattii strains among 124 persons with C. gattii infection, by age category, British Columbia, Canada, 1999–2007.

Mentions: The VGIIa strain was responsible for 107 (86.3%) of confirmed cases. Eight case-patients were infected with VGI and 9 with VGIIb. Clinical presentation did not differ significantly by genotype. However, strains differed by patient age; case-patients >50 years of age were more likely to be infected with VGIIa (p = 0.002) or VGIIb (p = 0.006) than with VGI (Figure 2).


Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007.

Galanis E, Macdougall L, Kidd S, Morshed M, British Columbia Cryptococcus gattii Working Gro - Emerging Infect. Dis. (2010)

Distribution of Cryptococcus gattii strains among 124 persons with C. gattii infection, by age category, British Columbia, Canada, 1999–2007.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2958008&req=5

Figure 2: Distribution of Cryptococcus gattii strains among 124 persons with C. gattii infection, by age category, British Columbia, Canada, 1999–2007.
Mentions: The VGIIa strain was responsible for 107 (86.3%) of confirmed cases. Eight case-patients were infected with VGI and 9 with VGIIb. Clinical presentation did not differ significantly by genotype. However, strains differed by patient age; case-patients >50 years of age were more likely to be infected with VGIIa (p = 0.002) or VGIIb (p = 0.006) than with VGI (Figure 2).

Bottom Line: The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain.Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains.Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.

View Article: PubMed Central - PubMed

Affiliation: British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada. eleni.galanis@bccdc.ca

ABSTRACT
British Columbia, Canada, has the largest reported population of Cryptococcus gattii-infected persons worldwide. To assess the impact of illness, we retrospectively analyzed demographic and clinical features of reported cases, hospitalizations, and deaths during 1999-2007. A total of 218 cases were reported (average annual incidence 5.8 per million persons). Most persons who sought treatment had respiratory illness (76.6%) or lung cryptococcoma (75.4%). Persons without HIV/AIDS hospitalized with cryptococcosis were more likely than those with HIV/AIDS to be older and admitted for pulmonary cryptococcosis. The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain. Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains. Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.

Show MeSH
Related in: MedlinePlus