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Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007.

Galanis E, Macdougall L, Kidd S, Morshed M, British Columbia Cryptococcus gattii Working Gro - Emerging Infect. Dis. (2010)

Bottom Line: The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain.Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains.Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.

View Article: PubMed Central - PubMed

Affiliation: British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada. eleni.galanis@bccdc.ca

ABSTRACT
British Columbia, Canada, has the largest reported population of Cryptococcus gattii-infected persons worldwide. To assess the impact of illness, we retrospectively analyzed demographic and clinical features of reported cases, hospitalizations, and deaths during 1999-2007. A total of 218 cases were reported (average annual incidence 5.8 per million persons). Most persons who sought treatment had respiratory illness (76.6%) or lung cryptococcoma (75.4%). Persons without HIV/AIDS hospitalized with cryptococcosis were more likely than those with HIV/AIDS to be older and admitted for pulmonary cryptococcosis. The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain. Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains. Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.

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Related in: MedlinePlus

Number of cases of Cryptococcus gattii infection and incidence rate per million population, by case-patient place of residence, British Columbia (BC), Canada, 1999–2007. Mainland, mainland BC; VI, Vancouver Island.
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Figure 1: Number of cases of Cryptococcus gattii infection and incidence rate per million population, by case-patient place of residence, British Columbia (BC), Canada, 1999–2007. Mainland, mainland BC; VI, Vancouver Island.

Mentions: A total of 218 cases (124 confirmed and 94 probable) of C. gattii infection were reported during 1999–2007 (Table 1). An average of 24.2 cases was reported every year (5.8/million/year); cases increased steadily from 6 in 1999 to 38 in 2006 (Figure 1). Onset did not vary by season or by month. Nearly three quarters (73.9%) of all case-patients lived on Vancouver Island (average annual incidence rate 25.1/million). The number of cases reported per year reached a plateau on Vancouver Island in 2002 but has increased on the mainland since 2005. Seven confirmed cases were acquired on the BC mainland (1 in 2004, 2 in 2005, 3 in 2006, and 1 in 2007).


Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007.

Galanis E, Macdougall L, Kidd S, Morshed M, British Columbia Cryptococcus gattii Working Gro - Emerging Infect. Dis. (2010)

Number of cases of Cryptococcus gattii infection and incidence rate per million population, by case-patient place of residence, British Columbia (BC), Canada, 1999–2007. Mainland, mainland BC; VI, Vancouver Island.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2958008&req=5

Figure 1: Number of cases of Cryptococcus gattii infection and incidence rate per million population, by case-patient place of residence, British Columbia (BC), Canada, 1999–2007. Mainland, mainland BC; VI, Vancouver Island.
Mentions: A total of 218 cases (124 confirmed and 94 probable) of C. gattii infection were reported during 1999–2007 (Table 1). An average of 24.2 cases was reported every year (5.8/million/year); cases increased steadily from 6 in 1999 to 38 in 2006 (Figure 1). Onset did not vary by season or by month. Nearly three quarters (73.9%) of all case-patients lived on Vancouver Island (average annual incidence rate 25.1/million). The number of cases reported per year reached a plateau on Vancouver Island in 2002 but has increased on the mainland since 2005. Seven confirmed cases were acquired on the BC mainland (1 in 2004, 2 in 2005, 3 in 2006, and 1 in 2007).

Bottom Line: The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain.Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains.Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.

View Article: PubMed Central - PubMed

Affiliation: British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada. eleni.galanis@bccdc.ca

ABSTRACT
British Columbia, Canada, has the largest reported population of Cryptococcus gattii-infected persons worldwide. To assess the impact of illness, we retrospectively analyzed demographic and clinical features of reported cases, hospitalizations, and deaths during 1999-2007. A total of 218 cases were reported (average annual incidence 5.8 per million persons). Most persons who sought treatment had respiratory illness (76.6%) or lung cryptococcoma (75.4%). Persons without HIV/AIDS hospitalized with cryptococcosis were more likely than those with HIV/AIDS to be older and admitted for pulmonary cryptococcosis. The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain. Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains. Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.

Show MeSH
Related in: MedlinePlus