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Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis.

Kurniawan J, Maharjan RP, Chan WF, Reeves PR, Sintchenko V, Gilbert GL, Mooi FR, Lan R - Emerging Infect. Dis. (2010)

Bottom Line: Multilocus variable-number tandem-repeat analysis (MLVA) of 316 Bordetella pertussis isolates collected over 40 years from Australia and 3 other continents identified 66 MLVA types (MTs), including 6 predominant MTs.Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia.

View Article: PubMed Central - PubMed

Affiliation: University of New South Wales, Sydney, New South Wales, Australia.

ABSTRACT
Multilocus variable-number tandem-repeat analysis (MLVA) of 316 Bordetella pertussis isolates collected over 40 years from Australia and 3 other continents identified 66 MLVA types (MTs), including 6 predominant MTs. Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia.

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Related in: MedlinePlus

Temporal trends of predominant multilocus variable-number tandem-repeat analysis (MLVA) types in Australia. Isolates of 4 major MLVA types (MT70, MT27, MT29, and MT64) obtained in Australia were divided into 3 periods: whole cell vaccine (WCV) (before 1997), transition from WCV to acellular vaccine (ACV) (1997–1999), and ACV (2000 onward).
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Figure 1: Temporal trends of predominant multilocus variable-number tandem-repeat analysis (MLVA) types in Australia. Isolates of 4 major MLVA types (MT70, MT27, MT29, and MT64) obtained in Australia were divided into 3 periods: whole cell vaccine (WCV) (before 1997), transition from WCV to acellular vaccine (ACV) (1997–1999), and ACV (2000 onward).

Mentions: The 208 isolates from Australia were grouped into 37 MTs, of which the 4 most prevalent represented 65.4% of the isolates: MT27, 13.5%, including 1 isolate from 1973 and the others from the 1990s to 2008; MT29, 21.6%, observed since 1972; MT70, 21.2%, 1996–2005, mostly since ACV introduction in 1997; and MT64, 9.1%, during 1989–2002. Prevalence trends of the 4 most common MTs were analyzed for 3 periods determined by vaccine type(s) in use: WCV (prior to 1997), the transition period of both WCV and ACV (1997–1999), and ACV only (2000 onward) (Figure 1). MT64 prevalence was steady over time. MT29 decreased while MT27 and MT70 increased. Trends in Australia for MT27 and MT29 were similar to those observed in the United Kingdom (11) and the Netherlands (10). D values were 0.86, 0.83, and 0.83 for WCV, transition, and ACV periods, respectively. This slight decrease in genetic diversity might indicate expansion of clones that are better adapted to ACV-induced immunity.


Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis.

Kurniawan J, Maharjan RP, Chan WF, Reeves PR, Sintchenko V, Gilbert GL, Mooi FR, Lan R - Emerging Infect. Dis. (2010)

Temporal trends of predominant multilocus variable-number tandem-repeat analysis (MLVA) types in Australia. Isolates of 4 major MLVA types (MT70, MT27, MT29, and MT64) obtained in Australia were divided into 3 periods: whole cell vaccine (WCV) (before 1997), transition from WCV to acellular vaccine (ACV) (1997–1999), and ACV (2000 onward).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2957989&req=5

Figure 1: Temporal trends of predominant multilocus variable-number tandem-repeat analysis (MLVA) types in Australia. Isolates of 4 major MLVA types (MT70, MT27, MT29, and MT64) obtained in Australia were divided into 3 periods: whole cell vaccine (WCV) (before 1997), transition from WCV to acellular vaccine (ACV) (1997–1999), and ACV (2000 onward).
Mentions: The 208 isolates from Australia were grouped into 37 MTs, of which the 4 most prevalent represented 65.4% of the isolates: MT27, 13.5%, including 1 isolate from 1973 and the others from the 1990s to 2008; MT29, 21.6%, observed since 1972; MT70, 21.2%, 1996–2005, mostly since ACV introduction in 1997; and MT64, 9.1%, during 1989–2002. Prevalence trends of the 4 most common MTs were analyzed for 3 periods determined by vaccine type(s) in use: WCV (prior to 1997), the transition period of both WCV and ACV (1997–1999), and ACV only (2000 onward) (Figure 1). MT64 prevalence was steady over time. MT29 decreased while MT27 and MT70 increased. Trends in Australia for MT27 and MT29 were similar to those observed in the United Kingdom (11) and the Netherlands (10). D values were 0.86, 0.83, and 0.83 for WCV, transition, and ACV periods, respectively. This slight decrease in genetic diversity might indicate expansion of clones that are better adapted to ACV-induced immunity.

Bottom Line: Multilocus variable-number tandem-repeat analysis (MLVA) of 316 Bordetella pertussis isolates collected over 40 years from Australia and 3 other continents identified 66 MLVA types (MTs), including 6 predominant MTs.Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia.

View Article: PubMed Central - PubMed

Affiliation: University of New South Wales, Sydney, New South Wales, Australia.

ABSTRACT
Multilocus variable-number tandem-repeat analysis (MLVA) of 316 Bordetella pertussis isolates collected over 40 years from Australia and 3 other continents identified 66 MLVA types (MTs), including 6 predominant MTs. Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia.

Show MeSH
Related in: MedlinePlus