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Maternal exposure to nitrogen dioxide during pregnancy and offspring birth weight: comparison of two exposure models.

Lepeule J, Caïni F, Bottagisi S, Galineau J, Hulin A, Marquis N, Bohet A, Siroux V, Kaminski M, Charles MA, Slama R, EDEN Mother–Child Cohort Study Gro - Environ. Health Perspect. (2010)

Bottom Line: The correlations between the two estimates of exposure during the first trimester of pregnancy were r = 0.67, 0.70, and 0.83 for women living within 5, 2, and 1 km of an AQMS, respectively.Exposure patterns displayed greater spatial than temporal variations.The association was less strong (higher p-value) for women living within 5 or 1 km of an AQMS.

View Article: PubMed Central - PubMed

Affiliation: INSERM, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, Institut Albert Bonniot, Grenoble, France. johanna.lepeule@ujf-grenoble.fr

ABSTRACT

Background: Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution.

Objective: We aimed to compare the exposure model based on the nearest AQMS and a temporally adjusted geostatistical (TAG) model with a finer spatial resolution, for use in pregnancy studies.

Methods: The AQMS and TAG exposure models were implemented in two areas surrounding medium-size cities in which 776 pregnant women were followed as part of the EDEN mother-child cohort. The exposure models were compared in terms of estimated nitrogen dioxide (NO2) levels and of their association with birth weight.

Results: The correlations between the two estimates of exposure during the first trimester of pregnancy were r = 0.67, 0.70, and 0.83 for women living within 5, 2, and 1 km of an AQMS, respectively. Exposure patterns displayed greater spatial than temporal variations. Exposure during the first trimester of pregnancy was most strongly associated with birth weight for women living < 2 km away from an AQMS: a 10-µg/m3 increase in NO2 exposure was associated with an adjusted difference in birth weight of -37 g [95% confidence interval (CI), -75 to 1 g] for the nearest-AQMS model and of -51 g (95% CI, -128 to 26 g) for the TAG model. The association was less strong (higher p-value) for women living within 5 or 1 km of an AQMS.

Conclusions: The two exposure models tended to give consistent results in terms of association with birth weight, despite the moderate concordance between exposure estimates.

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Related in: MedlinePlus

Change in mean birth weight (g) for a 10-μg/m3 increase in NO2 during pregnancy, as a function of the size of the buffer considered around each AQMS, adjusted for factors as described in “Materials and Methods.” Error bars indicate 95% CIs.
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f3-ehp-118-1483: Change in mean birth weight (g) for a 10-μg/m3 increase in NO2 during pregnancy, as a function of the size of the buffer considered around each AQMS, adjusted for factors as described in “Materials and Methods.” Error bars indicate 95% CIs.

Mentions: The patterns of association with birth weight identified were similar for the two exposure models, in terms of estimates of adjusted effects and confidence intervals (CIs), although these associations were stronger for the nearest-AQMS model [Figure 3; see also Supplemental Material, Table 1 (doi:10.1289/ehp.0901509)]. The first and third trimesters of pregnancy corresponded to the exposure windows most clearly associated with effects on birth weight, for both exposure models. For women living < 2 km from an AQMS, a 10-μg/m3 increase in NO2 concentration during the first trimester of pregnancy was associated with an adjusted change in mean birth weight of −37 g (95% CI, −75 to 1 g) for the nearest-AQMS model and of −51 g (95% CI, −128 to 26 g) for the TAG model. We obtained qualitatively similar results when we coded exposures in tertiles [see Supplemental Material, Table 1 (doi:10.1289/ehp.0901509)]. For the AQMS model, the parameter quantifying the association between NO2 exposure and birth weight approached zero as buffer size increased. We obtained similar results if we made no adjustment for city center (data not shown).


Maternal exposure to nitrogen dioxide during pregnancy and offspring birth weight: comparison of two exposure models.

Lepeule J, Caïni F, Bottagisi S, Galineau J, Hulin A, Marquis N, Bohet A, Siroux V, Kaminski M, Charles MA, Slama R, EDEN Mother–Child Cohort Study Gro - Environ. Health Perspect. (2010)

Change in mean birth weight (g) for a 10-μg/m3 increase in NO2 during pregnancy, as a function of the size of the buffer considered around each AQMS, adjusted for factors as described in “Materials and Methods.” Error bars indicate 95% CIs.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2957933&req=5

f3-ehp-118-1483: Change in mean birth weight (g) for a 10-μg/m3 increase in NO2 during pregnancy, as a function of the size of the buffer considered around each AQMS, adjusted for factors as described in “Materials and Methods.” Error bars indicate 95% CIs.
Mentions: The patterns of association with birth weight identified were similar for the two exposure models, in terms of estimates of adjusted effects and confidence intervals (CIs), although these associations were stronger for the nearest-AQMS model [Figure 3; see also Supplemental Material, Table 1 (doi:10.1289/ehp.0901509)]. The first and third trimesters of pregnancy corresponded to the exposure windows most clearly associated with effects on birth weight, for both exposure models. For women living < 2 km from an AQMS, a 10-μg/m3 increase in NO2 concentration during the first trimester of pregnancy was associated with an adjusted change in mean birth weight of −37 g (95% CI, −75 to 1 g) for the nearest-AQMS model and of −51 g (95% CI, −128 to 26 g) for the TAG model. We obtained qualitatively similar results when we coded exposures in tertiles [see Supplemental Material, Table 1 (doi:10.1289/ehp.0901509)]. For the AQMS model, the parameter quantifying the association between NO2 exposure and birth weight approached zero as buffer size increased. We obtained similar results if we made no adjustment for city center (data not shown).

Bottom Line: The correlations between the two estimates of exposure during the first trimester of pregnancy were r = 0.67, 0.70, and 0.83 for women living within 5, 2, and 1 km of an AQMS, respectively.Exposure patterns displayed greater spatial than temporal variations.The association was less strong (higher p-value) for women living within 5 or 1 km of an AQMS.

View Article: PubMed Central - PubMed

Affiliation: INSERM, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, Institut Albert Bonniot, Grenoble, France. johanna.lepeule@ujf-grenoble.fr

ABSTRACT

Background: Studies of the effects of air pollutants on birth weight often assess exposure with networks of permanent air quality monitoring stations (AQMSs), which have a poor spatial resolution.

Objective: We aimed to compare the exposure model based on the nearest AQMS and a temporally adjusted geostatistical (TAG) model with a finer spatial resolution, for use in pregnancy studies.

Methods: The AQMS and TAG exposure models were implemented in two areas surrounding medium-size cities in which 776 pregnant women were followed as part of the EDEN mother-child cohort. The exposure models were compared in terms of estimated nitrogen dioxide (NO2) levels and of their association with birth weight.

Results: The correlations between the two estimates of exposure during the first trimester of pregnancy were r = 0.67, 0.70, and 0.83 for women living within 5, 2, and 1 km of an AQMS, respectively. Exposure patterns displayed greater spatial than temporal variations. Exposure during the first trimester of pregnancy was most strongly associated with birth weight for women living < 2 km away from an AQMS: a 10-µg/m3 increase in NO2 exposure was associated with an adjusted difference in birth weight of -37 g [95% confidence interval (CI), -75 to 1 g] for the nearest-AQMS model and of -51 g (95% CI, -128 to 26 g) for the TAG model. The association was less strong (higher p-value) for women living within 5 or 1 km of an AQMS.

Conclusions: The two exposure models tended to give consistent results in terms of association with birth weight, despite the moderate concordance between exposure estimates.

Show MeSH
Related in: MedlinePlus