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Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutants.

Grandjean P, Poulsen LK, Heilmann C, Steuerwald U, Weihe P - Environ. Health Perspect. (2010)

Bottom Line: The total IgE concentration in serum at 7 years of age was positively associated both with the concomitant serum PCB concentration and with the duration of breast-feeding.However, the effect only of the latter was substantially attenuated in a multivariate analysis.However, a history of asthma or atopic dermatitis was not associated with the duration of breast-feeding, although children with atopic dermatitis had lower prenatal PCB exposures than did nonallergic children.

View Article: PubMed Central - PubMed

Affiliation: Institute of Public Health, University of Southern Denmark, Odense, Denmark. pgrand@hsph.harvard.edu

ABSTRACT

Background: Breast-feeding may affect the risk of developing allergy during childhood and may also cause exposure to immunotoxicants, such as polychlorinated biphenyls (PCBs), which are of concern as marine pollutants in the Faroe Islands and the Arctic region.

Objectives: The objective was to assess whether sensitization and development of allergic disease is associated with duration of breast-feeding and prenatal or postnatal exposures to PCBs and methylmercury.

Methods: A cohort of 656 singleton births was formed in the Faroe Islands during 1999-2001. Duration of breast-feeding and history of asthma and atopic dermatitis were recorded at clinical examinations at 5 and 7 years of age. PCB and mercury concentrations were determined in blood samples obtained at parturition and at follow-up. Serum from 464 children (71%) at 7 years of age was analyzed for total immunoglobulin E (IgE) and grass-specific IgE.

Results: The total IgE concentration in serum at 7 years of age was positively associated both with the concomitant serum PCB concentration and with the duration of breast-feeding. However, the effect only of the latter was substantially attenuated in a multivariate analysis. A raised grass-specific IgE concentration compatible with sensitization was positively associated with the duration of breast-feeding and inversely associated with prenatal methylmercury exposure. However, a history of asthma or atopic dermatitis was not associated with the duration of breast-feeding, although children with atopic dermatitis had lower prenatal PCB exposures than did nonallergic children.

Conclusions: These findings suggest that developmental exposure to immunotoxicants may both increase and decrease the risk of allergic disease and that associations between breast-feeding and subsequent allergic disease in children may, at least in part, reflect lactational exposure to immunotoxic food contaminants.

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Related in: MedlinePlus

Total IgE concentration in serum (log scale) in 464 children 7 years of age from a Faroese birth cohort in relation to the duration of exclusive breast-feeding: unadjusted regression line with the 95% confidence interval (A; p = 0.003) and results after adjustment for the child’s concomitant serum PCB concentration (B; p = 0.11).
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f1-ehp-118-1429: Total IgE concentration in serum (log scale) in 464 children 7 years of age from a Faroese birth cohort in relation to the duration of exclusive breast-feeding: unadjusted regression line with the 95% confidence interval (A; p = 0.003) and results after adjustment for the child’s concomitant serum PCB concentration (B; p = 0.11).

Mentions: Table 3 shows the exposure data within tertile groups of the total IgE concentrations at 7 years of age. All correlation coefficients were rather small (r < 0.2), but the p-values suggest that some of the associations could not be ascribed to chance. The highly significant positive correlations with the serum PCB concentration at 5 and 7 years of age suggested that a doubling in PCB was associated with an increase in total IgE of about 18%. We found a weaker tendency in the same direction for methylmercury exposure, but in this case only for prenatal exposure. Duration of breast-feeding also showed a positive association with IgE: Each month of exclusive breast-feeding was associated with an average increase of total IgE of 12%. However, when adjusted for serum PCB at 7 years of age in a multiple regression analysis, the increase in IgE for each month of breast-feeding decreased to 6% (p = 0.13) (Figure 1); the regression coefficient for PCB decreased marginally to 17% in this analysis and remained statistically significant (p = 0.02). Maternal fish intake during pregnancy, as a measure of prenatal exposure to n-3 fatty acids, was not associated with the child’s total IgE concentration (p = 0.28). Other covariates did not materially affect these associations.


Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutants.

Grandjean P, Poulsen LK, Heilmann C, Steuerwald U, Weihe P - Environ. Health Perspect. (2010)

Total IgE concentration in serum (log scale) in 464 children 7 years of age from a Faroese birth cohort in relation to the duration of exclusive breast-feeding: unadjusted regression line with the 95% confidence interval (A; p = 0.003) and results after adjustment for the child’s concomitant serum PCB concentration (B; p = 0.11).
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2957924&req=5

f1-ehp-118-1429: Total IgE concentration in serum (log scale) in 464 children 7 years of age from a Faroese birth cohort in relation to the duration of exclusive breast-feeding: unadjusted regression line with the 95% confidence interval (A; p = 0.003) and results after adjustment for the child’s concomitant serum PCB concentration (B; p = 0.11).
Mentions: Table 3 shows the exposure data within tertile groups of the total IgE concentrations at 7 years of age. All correlation coefficients were rather small (r < 0.2), but the p-values suggest that some of the associations could not be ascribed to chance. The highly significant positive correlations with the serum PCB concentration at 5 and 7 years of age suggested that a doubling in PCB was associated with an increase in total IgE of about 18%. We found a weaker tendency in the same direction for methylmercury exposure, but in this case only for prenatal exposure. Duration of breast-feeding also showed a positive association with IgE: Each month of exclusive breast-feeding was associated with an average increase of total IgE of 12%. However, when adjusted for serum PCB at 7 years of age in a multiple regression analysis, the increase in IgE for each month of breast-feeding decreased to 6% (p = 0.13) (Figure 1); the regression coefficient for PCB decreased marginally to 17% in this analysis and remained statistically significant (p = 0.02). Maternal fish intake during pregnancy, as a measure of prenatal exposure to n-3 fatty acids, was not associated with the child’s total IgE concentration (p = 0.28). Other covariates did not materially affect these associations.

Bottom Line: The total IgE concentration in serum at 7 years of age was positively associated both with the concomitant serum PCB concentration and with the duration of breast-feeding.However, the effect only of the latter was substantially attenuated in a multivariate analysis.However, a history of asthma or atopic dermatitis was not associated with the duration of breast-feeding, although children with atopic dermatitis had lower prenatal PCB exposures than did nonallergic children.

View Article: PubMed Central - PubMed

Affiliation: Institute of Public Health, University of Southern Denmark, Odense, Denmark. pgrand@hsph.harvard.edu

ABSTRACT

Background: Breast-feeding may affect the risk of developing allergy during childhood and may also cause exposure to immunotoxicants, such as polychlorinated biphenyls (PCBs), which are of concern as marine pollutants in the Faroe Islands and the Arctic region.

Objectives: The objective was to assess whether sensitization and development of allergic disease is associated with duration of breast-feeding and prenatal or postnatal exposures to PCBs and methylmercury.

Methods: A cohort of 656 singleton births was formed in the Faroe Islands during 1999-2001. Duration of breast-feeding and history of asthma and atopic dermatitis were recorded at clinical examinations at 5 and 7 years of age. PCB and mercury concentrations were determined in blood samples obtained at parturition and at follow-up. Serum from 464 children (71%) at 7 years of age was analyzed for total immunoglobulin E (IgE) and grass-specific IgE.

Results: The total IgE concentration in serum at 7 years of age was positively associated both with the concomitant serum PCB concentration and with the duration of breast-feeding. However, the effect only of the latter was substantially attenuated in a multivariate analysis. A raised grass-specific IgE concentration compatible with sensitization was positively associated with the duration of breast-feeding and inversely associated with prenatal methylmercury exposure. However, a history of asthma or atopic dermatitis was not associated with the duration of breast-feeding, although children with atopic dermatitis had lower prenatal PCB exposures than did nonallergic children.

Conclusions: These findings suggest that developmental exposure to immunotoxicants may both increase and decrease the risk of allergic disease and that associations between breast-feeding and subsequent allergic disease in children may, at least in part, reflect lactational exposure to immunotoxic food contaminants.

Show MeSH
Related in: MedlinePlus