Sexual dimorphism in the fly brain.
Bottom Line: Initial work found limited evidence for anatomical dimorphism in these fru+ neurons.Our analysis reveals substantial differences in wiring and gross anatomy between male and female fly brains.Reciprocal connection differences in the lateral horn offer a plausible explanation for opposing responses to sex pheromones in male and female flies.
Affiliation: Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK.Show MeSH
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Mentions: Most PN axons make en passant connections in the mushroom body calyx before terminating in the lateral horn (LH). It has previously been shown that many mushroom body neurons are fru+. We confirmed this but found no overt anatomical dimorphism in these cells. In the LH, we identified eight fru+ third-order olfactory neuron lineages. In contrast to the mushroom bodies, seven of eight LH clones have dimorphic projections (Figure 2; Figure 5); three also differ in cell number (Table 1). The sole exception is a pair of local interneurons (pSP-f; see Figure S2). The seven dimorphic clones all have input regions in the LH and output regions in other parts of the brain and can therefore be considered to be principal neurons of the lateral horn (LHNs).
Affiliation: Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK.