Sexual dimorphism in the fly brain.
Bottom Line: Initial work found limited evidence for anatomical dimorphism in these fru+ neurons.Our analysis reveals substantial differences in wiring and gross anatomy between male and female fly brains.Reciprocal connection differences in the lateral horn offer a plausible explanation for opposing responses to sex pheromones in male and female flies.
Affiliation: Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK.Show MeSH
Related in: MedlinePlus
Mentions: Having identified the comprehensive set of dimorphisms in fru+ neurons, we asked where these dimorphisms are located in the brain. We isolated the dimorphic arbors from the 21 clones in Figure 2 and overlaid them on our template brain (Figure 3A). Dimorphic arbors are widespread in males, extending over 11% of the neuropil (see Experimental Procedures) and potentially forming sex-specific connections with many different neurons. In females, dimorphic arbors extend over 2.1% of the brain. Although widely distributed, dimorphic arbors are heavily enriched in specific brain regions.
Affiliation: Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK.