Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000.
Bottom Line: Activation of iNKT cells is known to lead to the production of cytokines that can help alleviate or exacerbate these conditions. alpha-Galactosyl ceramide (alpha-GalCer) is a known agonist of iNKT cells and it is believed that its fucosyl counterpart might have similar immunogenic properties.We herein report the synthesis of alpha-L-fucosyl ceramide derivatives and describe their biological evaluation.The key challenge in the synthesis of the target molecules involved the stereoselective synthesis of the alpha-glycosidic linkage.
Affiliation: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.Show MeSH
Related in: MedlinePlus
Affiliation: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.