Limits...
Plasma cell granuloma of the thyroid: a conservative approach to a rare condition and review of the literature.

Barber WA, Fernando M, Chadwick DR - J Thyroid Res (2010)

Bottom Line: TSH levels improved and the lump showed signs of regression.Conclusion.We present a new approach to management without the use of surgery or steroids.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Chesterfield Royal Hospital, Calow, Chesterfield S44 5BL, UK.

ABSTRACT
Introduction. We present a case of an 89-year-old female who attended our surgical endocrine clinic with a 3-month history of a left-sided neck lump. There was no past medical history of thyroid disease. Methods. Following examination and further investigation, including core biopsy, a diagnosis of plasma cell granuloma of the thyroid was made. Biochemical testing of thyroid function and Thyroid Peroxidase Antibody was in-keeping with an associated Hashimoto's thyroiditis. Results. The patient was treated conservatively with thyroxine and regularly seen in clinic. TSH levels improved and the lump showed signs of regression. Conclusion. Plasma cell granuloma of the thyroid is rare with only 16 previously reported cases. We present a new approach to management without the use of surgery or steroids. The literature is reviewed comparing clinico-pathological features and management of other reported cases.

No MeSH data available.


Related in: MedlinePlus

Staining for kappa (a) and lambda (b) light chains to confirm polyclonality (both ×200).
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fig2: Staining for kappa (a) and lambda (b) light chains to confirm polyclonality (both ×200).

Mentions: Two core biopsies both measuring 15 mm were obtained for histological examination. This showed a heavy plasma cell infiltrate and admixed B- and T-lymphocytes (Figure 1). The plasma cell infiltrate was polyclonal (Figure 2) and expressed CD79a, CD138, and MUM-1. There was no evidence of anaplastic carcinoma or other primary thyroid carcinoma. There were no morphological features to suggest Riedels thyroiditis.


Plasma cell granuloma of the thyroid: a conservative approach to a rare condition and review of the literature.

Barber WA, Fernando M, Chadwick DR - J Thyroid Res (2010)

Staining for kappa (a) and lambda (b) light chains to confirm polyclonality (both ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2957798&req=5

fig2: Staining for kappa (a) and lambda (b) light chains to confirm polyclonality (both ×200).
Mentions: Two core biopsies both measuring 15 mm were obtained for histological examination. This showed a heavy plasma cell infiltrate and admixed B- and T-lymphocytes (Figure 1). The plasma cell infiltrate was polyclonal (Figure 2) and expressed CD79a, CD138, and MUM-1. There was no evidence of anaplastic carcinoma or other primary thyroid carcinoma. There were no morphological features to suggest Riedels thyroiditis.

Bottom Line: TSH levels improved and the lump showed signs of regression.Conclusion.We present a new approach to management without the use of surgery or steroids.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Chesterfield Royal Hospital, Calow, Chesterfield S44 5BL, UK.

ABSTRACT
Introduction. We present a case of an 89-year-old female who attended our surgical endocrine clinic with a 3-month history of a left-sided neck lump. There was no past medical history of thyroid disease. Methods. Following examination and further investigation, including core biopsy, a diagnosis of plasma cell granuloma of the thyroid was made. Biochemical testing of thyroid function and Thyroid Peroxidase Antibody was in-keeping with an associated Hashimoto's thyroiditis. Results. The patient was treated conservatively with thyroxine and regularly seen in clinic. TSH levels improved and the lump showed signs of regression. Conclusion. Plasma cell granuloma of the thyroid is rare with only 16 previously reported cases. We present a new approach to management without the use of surgery or steroids. The literature is reviewed comparing clinico-pathological features and management of other reported cases.

No MeSH data available.


Related in: MedlinePlus