Limits...
Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial.

Hafkamp-de Groen E, Mohangoo AD, de Jongste JC, van der Wouden JC, Moll HA, Jaddoe VW, Hofman A, de Koning HJ, Raat H - BMC Public Health (2010)

Bottom Line: Prevention of childhood asthma is an important public health objective.Analysis was according to the intention-to-treat principle.Data collection will be completed end 2011.

View Article: PubMed Central - HTML - PubMed

Affiliation: The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands. e.hafkamp@erasmusmc.nl

ABSTRACT

Background: Prevention of childhood asthma is an important public health objective. This study evaluates the effectiveness of early detection of preschool children with asthma symptoms, followed by a counselling intervention at preventive child health centres. Early detection and counselling is expected to reduce the prevalence of asthma symptoms and improve health-related quality of life at age 6 years.

Methods/design: This cluster randomised controlled trial was embedded within the Rotterdam population-based prospective cohort study Generation R in which 7893 children (born between April 2002 and January 2006) participated in the postnatal phase. Sixteen child health centres are involved, randomised into 8 intervention and 8 control centres. Since June 2005, an early detection tool has been applied at age 14, 24, 36 and 45 months at the intervention centres. Children who met the intervention criteria received counselling intervention (personal advice to parents to prevent smoke exposure of the child, and/or referral to the general practitioner or asthma nurse). The primary outcome was asthma diagnosis at age 6 years. Secondary outcomes included frequency and severity of asthma symptoms, health-related quality of life, fractional exhaled nitric oxide and airway resistance at age 6 years. Analysis was according to the intention-to-treat principle. Data collection will be completed end 2011.

Discussion: This study among preschool children provides insight into the effectiveness of early detection of asthma symptoms followed by a counselling intervention at preventive child health centres.

Trial registration: Current Controlled Trials ISRCTN15790308.

Show MeSH

Related in: MedlinePlus

Study design. The flow of participants through the randomised controlled trial for early detection of asthma symptoms and application of the counselling intervention.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2944378&req=5

Figure 1: Study design. The flow of participants through the randomised controlled trial for early detection of asthma symptoms and application of the counselling intervention.

Mentions: The Generation R cohort included 9778 pregnant women living in Rotterdam, the Netherlands. The participating women gave birth to 9745 live-born children between April 2002 and January 2006. A total of 7893 children participated in the postnatal phase [25]. The cohort for the early detection and counselling intervention of asthma symptoms consisted of all 7775 children participating in the postnatal phase of the Generation R study and living in the intervention area (Rotterdam-North, defined by postal codes 3010-3070) (Figure 1).


Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial.

Hafkamp-de Groen E, Mohangoo AD, de Jongste JC, van der Wouden JC, Moll HA, Jaddoe VW, Hofman A, de Koning HJ, Raat H - BMC Public Health (2010)

Study design. The flow of participants through the randomised controlled trial for early detection of asthma symptoms and application of the counselling intervention.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2944378&req=5

Figure 1: Study design. The flow of participants through the randomised controlled trial for early detection of asthma symptoms and application of the counselling intervention.
Mentions: The Generation R cohort included 9778 pregnant women living in Rotterdam, the Netherlands. The participating women gave birth to 9745 live-born children between April 2002 and January 2006. A total of 7893 children participated in the postnatal phase [25]. The cohort for the early detection and counselling intervention of asthma symptoms consisted of all 7775 children participating in the postnatal phase of the Generation R study and living in the intervention area (Rotterdam-North, defined by postal codes 3010-3070) (Figure 1).

Bottom Line: Prevention of childhood asthma is an important public health objective.Analysis was according to the intention-to-treat principle.Data collection will be completed end 2011.

View Article: PubMed Central - HTML - PubMed

Affiliation: The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands. e.hafkamp@erasmusmc.nl

ABSTRACT

Background: Prevention of childhood asthma is an important public health objective. This study evaluates the effectiveness of early detection of preschool children with asthma symptoms, followed by a counselling intervention at preventive child health centres. Early detection and counselling is expected to reduce the prevalence of asthma symptoms and improve health-related quality of life at age 6 years.

Methods/design: This cluster randomised controlled trial was embedded within the Rotterdam population-based prospective cohort study Generation R in which 7893 children (born between April 2002 and January 2006) participated in the postnatal phase. Sixteen child health centres are involved, randomised into 8 intervention and 8 control centres. Since June 2005, an early detection tool has been applied at age 14, 24, 36 and 45 months at the intervention centres. Children who met the intervention criteria received counselling intervention (personal advice to parents to prevent smoke exposure of the child, and/or referral to the general practitioner or asthma nurse). The primary outcome was asthma diagnosis at age 6 years. Secondary outcomes included frequency and severity of asthma symptoms, health-related quality of life, fractional exhaled nitric oxide and airway resistance at age 6 years. Analysis was according to the intention-to-treat principle. Data collection will be completed end 2011.

Discussion: This study among preschool children provides insight into the effectiveness of early detection of asthma symptoms followed by a counselling intervention at preventive child health centres.

Trial registration: Current Controlled Trials ISRCTN15790308.

Show MeSH
Related in: MedlinePlus