Limits...
African-American inflammatory bowel disease in a Southern U.S. health center.

Veluswamy H, Suryawala K, Sheth A, Wells S, Salvatierra E, Cromer W, Chaitanya GV, Painter A, Patel M, Manas K, Zwank E, Boktor M, Baig K, Datti B, Mathis MJ, Minagar A, Jordan PA, Alexander JS - BMC Gastroenterol (2010)

Bottom Line: Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0).Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Dept of Molecular & Cellular Physiology, 1501 Kings Highway, Shreveport, LA, 71130-3932, USA.

ABSTRACT

Background: Inflammatory Bowel Diseases (IBD) remain significant health problems in the US and worldwide. IBD is most often associated with eastern European ancestry, and is less frequently reported in other populations of African origin e.g. African Americans ('AAs'). Whether AAs represent an important population with IBD in the US remains unclear since few studies have investigated IBD in communities with a majority representation of AA patients. The Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S) is a tertiary care medical center, with a patient base composed of 58% AA and 39% Caucasian (W), ideal for evaluating racial (AA vs. W) as well and gender (M vs. F) influences on IBD.

Methods: In this retrospective study, we evaluated 951 visits to LSUHSC-S for IBD (between 2000 to 2008) using non-identified patient information based on ICD-9 medical record coding (Crohn's disease 'CD'-555.0- 555.9 and ulcerative colitis 'UC'-556.0-556.9).

Results: Overall, there were more cases of CD seen than UC. UC and CD affected similar ratios of AA and Caucasian males (M) and females (F) with a rank order of WF > WM > AAF > AAM. Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0). Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.

Conclusion: Although Caucasians still represent the greatest fraction of IBD (~64%), AAs with IBD made up >1/3 (36.4%) of annual IBD cases from 2000-2008 at LSUHSC-S. Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

Show MeSH

Related in: MedlinePlus

Ratio comparison for Crohn's disease between A) Caucasians: AAs and B) females: males. In fig. 4A, Crohn's affects more Caucasian than AA individuals (irrespective of genders). When comparing the W: B ratio, men were affected more than women (**, p < 0.01). In fig. 4B, Crohn's was seen to affect more women than men amongst both races. When comparing this ratio (F: M), AA individuals are affected more than Caucasian (**, p < 0.01). Results were compared using two-tailed unpaired student t-test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2944337&req=5

Figure 4: Ratio comparison for Crohn's disease between A) Caucasians: AAs and B) females: males. In fig. 4A, Crohn's affects more Caucasian than AA individuals (irrespective of genders). When comparing the W: B ratio, men were affected more than women (**, p < 0.01). In fig. 4B, Crohn's was seen to affect more women than men amongst both races. When comparing this ratio (F: M), AA individuals are affected more than Caucasian (**, p < 0.01). Results were compared using two-tailed unpaired student t-test.

Mentions: At LSUHSC-Shreveport, IBD affected more Caucasian (64%) than AA individuals (36%). We also compared the ratios of gender and race for both CD and UC. When comparing this ratio (W: B), men were affected more than women in CD (**, p < 0.01) (Fig. 4A). In UC when comparing the same ratio (W: B) between men and women, no significant difference was found (Fig. 5A). In both CD and UC women were more affected than men among both races. When comparing the F: M ratio, AAs were more affected than Caucasian (**, p < 0.01) amongst CD patients (Fig. 4B), however comparing the F: M ratio in UC, showed no significant difference (Fig. 5B).


African-American inflammatory bowel disease in a Southern U.S. health center.

Veluswamy H, Suryawala K, Sheth A, Wells S, Salvatierra E, Cromer W, Chaitanya GV, Painter A, Patel M, Manas K, Zwank E, Boktor M, Baig K, Datti B, Mathis MJ, Minagar A, Jordan PA, Alexander JS - BMC Gastroenterol (2010)

Ratio comparison for Crohn's disease between A) Caucasians: AAs and B) females: males. In fig. 4A, Crohn's affects more Caucasian than AA individuals (irrespective of genders). When comparing the W: B ratio, men were affected more than women (**, p < 0.01). In fig. 4B, Crohn's was seen to affect more women than men amongst both races. When comparing this ratio (F: M), AA individuals are affected more than Caucasian (**, p < 0.01). Results were compared using two-tailed unpaired student t-test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2944337&req=5

Figure 4: Ratio comparison for Crohn's disease between A) Caucasians: AAs and B) females: males. In fig. 4A, Crohn's affects more Caucasian than AA individuals (irrespective of genders). When comparing the W: B ratio, men were affected more than women (**, p < 0.01). In fig. 4B, Crohn's was seen to affect more women than men amongst both races. When comparing this ratio (F: M), AA individuals are affected more than Caucasian (**, p < 0.01). Results were compared using two-tailed unpaired student t-test.
Mentions: At LSUHSC-Shreveport, IBD affected more Caucasian (64%) than AA individuals (36%). We also compared the ratios of gender and race for both CD and UC. When comparing this ratio (W: B), men were affected more than women in CD (**, p < 0.01) (Fig. 4A). In UC when comparing the same ratio (W: B) between men and women, no significant difference was found (Fig. 5A). In both CD and UC women were more affected than men among both races. When comparing the F: M ratio, AAs were more affected than Caucasian (**, p < 0.01) amongst CD patients (Fig. 4B), however comparing the F: M ratio in UC, showed no significant difference (Fig. 5B).

Bottom Line: Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0).Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Dept of Molecular & Cellular Physiology, 1501 Kings Highway, Shreveport, LA, 71130-3932, USA.

ABSTRACT

Background: Inflammatory Bowel Diseases (IBD) remain significant health problems in the US and worldwide. IBD is most often associated with eastern European ancestry, and is less frequently reported in other populations of African origin e.g. African Americans ('AAs'). Whether AAs represent an important population with IBD in the US remains unclear since few studies have investigated IBD in communities with a majority representation of AA patients. The Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S) is a tertiary care medical center, with a patient base composed of 58% AA and 39% Caucasian (W), ideal for evaluating racial (AA vs. W) as well and gender (M vs. F) influences on IBD.

Methods: In this retrospective study, we evaluated 951 visits to LSUHSC-S for IBD (between 2000 to 2008) using non-identified patient information based on ICD-9 medical record coding (Crohn's disease 'CD'-555.0- 555.9 and ulcerative colitis 'UC'-556.0-556.9).

Results: Overall, there were more cases of CD seen than UC. UC and CD affected similar ratios of AA and Caucasian males (M) and females (F) with a rank order of WF > WM > AAF > AAM. Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0). Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.

Conclusion: Although Caucasians still represent the greatest fraction of IBD (~64%), AAs with IBD made up >1/3 (36.4%) of annual IBD cases from 2000-2008 at LSUHSC-S. Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

Show MeSH
Related in: MedlinePlus