Limits...
African-American inflammatory bowel disease in a Southern U.S. health center.

Veluswamy H, Suryawala K, Sheth A, Wells S, Salvatierra E, Cromer W, Chaitanya GV, Painter A, Patel M, Manas K, Zwank E, Boktor M, Baig K, Datti B, Mathis MJ, Minagar A, Jordan PA, Alexander JS - BMC Gastroenterol (2010)

Bottom Line: Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0).Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Dept of Molecular & Cellular Physiology, 1501 Kings Highway, Shreveport, LA, 71130-3932, USA.

ABSTRACT

Background: Inflammatory Bowel Diseases (IBD) remain significant health problems in the US and worldwide. IBD is most often associated with eastern European ancestry, and is less frequently reported in other populations of African origin e.g. African Americans ('AAs'). Whether AAs represent an important population with IBD in the US remains unclear since few studies have investigated IBD in communities with a majority representation of AA patients. The Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S) is a tertiary care medical center, with a patient base composed of 58% AA and 39% Caucasian (W), ideal for evaluating racial (AA vs. W) as well and gender (M vs. F) influences on IBD.

Methods: In this retrospective study, we evaluated 951 visits to LSUHSC-S for IBD (between 2000 to 2008) using non-identified patient information based on ICD-9 medical record coding (Crohn's disease 'CD'-555.0- 555.9 and ulcerative colitis 'UC'-556.0-556.9).

Results: Overall, there were more cases of CD seen than UC. UC and CD affected similar ratios of AA and Caucasian males (M) and females (F) with a rank order of WF > WM > AAF > AAM. Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0). Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.

Conclusion: Although Caucasians still represent the greatest fraction of IBD (~64%), AAs with IBD made up >1/3 (36.4%) of annual IBD cases from 2000-2008 at LSUHSC-S. Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

Show MeSH

Related in: MedlinePlus

Percent distribution of CD and UC in Shreveport, LA (2000-8). There is a strikingly similar distribution in CD and UC gender and race over a total of 9 years in Shreveport, LA. 665 CD patients and 286 UC patients were included in this study. There was variability and no correlation when data analyzed annually.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2944337&req=5

Figure 1: Percent distribution of CD and UC in Shreveport, LA (2000-8). There is a strikingly similar distribution in CD and UC gender and race over a total of 9 years in Shreveport, LA. 665 CD patients and 286 UC patients were included in this study. There was variability and no correlation when data analyzed annually.

Mentions: Data were collected on patients with CD and UC at LSUHSC-S between 2000-8. The compiled data set included: 1) the total number of annual visits, 2) the annual number of cases, 3) the age at visit for each disease and 4) these factors separated both by genders and by race at LSUHSC-S. Over the past 9 years, 665 patients with CD and 286 with UC treated at LSUHSC-S were included in this study. Of CD patients, 428 (64.36%) were Caucasian, and 237 (35.64%) were African-American. When the CD population was subdivided by race and gender, 240 (36.09%) were Caucasian Fs, 188 (28.27%) were Caucasian M, 150 (22.56%) were AA F, and 87 (13.08%) were AA M. Caucasians represented 63.99% (183) of UC patients, while African-Americans comprised 36.01% (103) in this study. When UC patients were subdivided by race and gender, 38.46% (110) were Caucasian F, 25.52% (73) were Caucasian M, 23.08% (66) were AA F, and 12.94% (37) were AA M (Fig. 1). It is important to point out that because our study only examined unidentified hospital records, the results only reflect institutional trends; and calculation of true regional or geographical incidences would require additional data on patient residence.


African-American inflammatory bowel disease in a Southern U.S. health center.

Veluswamy H, Suryawala K, Sheth A, Wells S, Salvatierra E, Cromer W, Chaitanya GV, Painter A, Patel M, Manas K, Zwank E, Boktor M, Baig K, Datti B, Mathis MJ, Minagar A, Jordan PA, Alexander JS - BMC Gastroenterol (2010)

Percent distribution of CD and UC in Shreveport, LA (2000-8). There is a strikingly similar distribution in CD and UC gender and race over a total of 9 years in Shreveport, LA. 665 CD patients and 286 UC patients were included in this study. There was variability and no correlation when data analyzed annually.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2944337&req=5

Figure 1: Percent distribution of CD and UC in Shreveport, LA (2000-8). There is a strikingly similar distribution in CD and UC gender and race over a total of 9 years in Shreveport, LA. 665 CD patients and 286 UC patients were included in this study. There was variability and no correlation when data analyzed annually.
Mentions: Data were collected on patients with CD and UC at LSUHSC-S between 2000-8. The compiled data set included: 1) the total number of annual visits, 2) the annual number of cases, 3) the age at visit for each disease and 4) these factors separated both by genders and by race at LSUHSC-S. Over the past 9 years, 665 patients with CD and 286 with UC treated at LSUHSC-S were included in this study. Of CD patients, 428 (64.36%) were Caucasian, and 237 (35.64%) were African-American. When the CD population was subdivided by race and gender, 240 (36.09%) were Caucasian Fs, 188 (28.27%) were Caucasian M, 150 (22.56%) were AA F, and 87 (13.08%) were AA M. Caucasians represented 63.99% (183) of UC patients, while African-Americans comprised 36.01% (103) in this study. When UC patients were subdivided by race and gender, 38.46% (110) were Caucasian F, 25.52% (73) were Caucasian M, 23.08% (66) were AA F, and 12.94% (37) were AA M (Fig. 1). It is important to point out that because our study only examined unidentified hospital records, the results only reflect institutional trends; and calculation of true regional or geographical incidences would require additional data on patient residence.

Bottom Line: Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0).Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Dept of Molecular & Cellular Physiology, 1501 Kings Highway, Shreveport, LA, 71130-3932, USA.

ABSTRACT

Background: Inflammatory Bowel Diseases (IBD) remain significant health problems in the US and worldwide. IBD is most often associated with eastern European ancestry, and is less frequently reported in other populations of African origin e.g. African Americans ('AAs'). Whether AAs represent an important population with IBD in the US remains unclear since few studies have investigated IBD in communities with a majority representation of AA patients. The Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S) is a tertiary care medical center, with a patient base composed of 58% AA and 39% Caucasian (W), ideal for evaluating racial (AA vs. W) as well and gender (M vs. F) influences on IBD.

Methods: In this retrospective study, we evaluated 951 visits to LSUHSC-S for IBD (between 2000 to 2008) using non-identified patient information based on ICD-9 medical record coding (Crohn's disease 'CD'-555.0- 555.9 and ulcerative colitis 'UC'-556.0-556.9).

Results: Overall, there were more cases of CD seen than UC. UC and CD affected similar ratios of AA and Caucasian males (M) and females (F) with a rank order of WF > WM > AAF > AAM. Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0). Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.

Conclusion: Although Caucasians still represent the greatest fraction of IBD (~64%), AAs with IBD made up >1/3 (36.4%) of annual IBD cases from 2000-2008 at LSUHSC-S. Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

Show MeSH
Related in: MedlinePlus