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Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China.

Liu H, Liu Y, Wang L, Xu D, Lin B, Zhong R, Gong S, Podda M, Invernizzi P - BMC Gastroenterol (2010)

Bottom Line: Fourteen in the 39 individuals positive for AMA at IIF, AMA-M2, anti-gp210, or anti-sp100 had abnormal cholestatic liver functional indices.One definite and 3 probable PBC diagnosis could be made in 4 cases including 3 females and 1 male after half a year.We found a point prevalence rate of PBC among Southern Chinese adults attending for yearly health check-up of 492 cases per million (95% CI, 128 to 1,093) and 1,558 cases per million (95% CI, 294 to 3,815) for women over 40, a finding similar to prevalence reported in other geographical areas.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinical Laboratory, Guangzhou Women and Children’s Medical Center, 9 Jinsui Road, Guangzhou 510623, China.

ABSTRACT

Background: Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of anti-mitocondrial autoantibodies (AMA) which has an essential role also for diagnosis. In addition, also some anti-nuclear antibodies (ANA) have been shown to be highly specific PBC. The purpose of this study was to assess the prevalence of PBC among the adults referring hospital for annual health check-up in Southern China by screening sera for PBC-specific autoantibodies.

Methods: AMA and ANA were screened in 8,126 adults (mean age 44 ± 15 years, 48% females) by indirect immunofluorenscence (IIF). Positive sera were tested by ELISA/immunoblotting for AMA-M2, anti-sp100 and anti-gp210. A diagnosis of PBC was re-assessed six months after the initial testing.

Results: Out of 8,126 individuals 35 were positive for AMA and 79 positive for ANA. Nineteen, 4, and 3 of the subjects positive for AMA and/or ANA showed reactivity for AMA-M2, anti-sp100 or gp210, respectively, further tested with ELISA/immunoblotting. Fourteen in the 39 individuals positive for AMA at IIF, AMA-M2, anti-gp210, or anti-sp100 had abnormal cholestatic liver functional indices. One definite and 3 probable PBC diagnosis could be made in 4 cases including 3 females and 1 male after half a year.

Conclusions: We found a point prevalence rate of PBC among Southern Chinese adults attending for yearly health check-up of 492 cases per million (95% CI, 128 to 1,093) and 1,558 cases per million (95% CI, 294 to 3,815) for women over 40, a finding similar to prevalence reported in other geographical areas.

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Related in: MedlinePlus

Distribution of PBC-specific autoantibodies in male and female at different ages. None of PBC-specific autoantibodies (AMA-M2, anti-sp100 or anti-gp210) was detected in the individuals at the age of 18~29. There was no significant difference in the frequency of PBC-specific autoantibodies between male and female at all ages (P > 0.05).
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Figure 2: Distribution of PBC-specific autoantibodies in male and female at different ages. None of PBC-specific autoantibodies (AMA-M2, anti-sp100 or anti-gp210) was detected in the individuals at the age of 18~29. There was no significant difference in the frequency of PBC-specific autoantibodies between male and female at all ages (P > 0.05).

Mentions: Twenty-two of the 104 sera (22%) that tested positive for AMA and/or ANA by IIF contained autoantibodies directed against specific mitochondrial and/or nuclear antigens as shown in table 2. In particular, 19, 4, and 3 of these 104 sera were found to be positive for anti-AMA-M2, anti-sp100 and anti-gp210, respectively. Distribution of PBC-specific autoantibodies including AMA-M2, anti-sp100 and anti-gp210 in male vs. female at different ages was shown in figure 2. None of specific autoantibodies (anti-AMA-M2, anti-sp100 or anti-gp210) was detected in the individuals at the age of 18~29. These autoantibodies occurred seldom in adults before age of 40 and the positive rates did not increased with age (P > 0.05). Although the PBC-specific autoantibodies prevalence in female over age of 40 was 0.62% and 1.32% for women over 60, several folds of that found among males of similar age, there was no statistical difference between female and male at all ages (P > 0.05).


Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China.

Liu H, Liu Y, Wang L, Xu D, Lin B, Zhong R, Gong S, Podda M, Invernizzi P - BMC Gastroenterol (2010)

Distribution of PBC-specific autoantibodies in male and female at different ages. None of PBC-specific autoantibodies (AMA-M2, anti-sp100 or anti-gp210) was detected in the individuals at the age of 18~29. There was no significant difference in the frequency of PBC-specific autoantibodies between male and female at all ages (P > 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2944334&req=5

Figure 2: Distribution of PBC-specific autoantibodies in male and female at different ages. None of PBC-specific autoantibodies (AMA-M2, anti-sp100 or anti-gp210) was detected in the individuals at the age of 18~29. There was no significant difference in the frequency of PBC-specific autoantibodies between male and female at all ages (P > 0.05).
Mentions: Twenty-two of the 104 sera (22%) that tested positive for AMA and/or ANA by IIF contained autoantibodies directed against specific mitochondrial and/or nuclear antigens as shown in table 2. In particular, 19, 4, and 3 of these 104 sera were found to be positive for anti-AMA-M2, anti-sp100 and anti-gp210, respectively. Distribution of PBC-specific autoantibodies including AMA-M2, anti-sp100 and anti-gp210 in male vs. female at different ages was shown in figure 2. None of specific autoantibodies (anti-AMA-M2, anti-sp100 or anti-gp210) was detected in the individuals at the age of 18~29. These autoantibodies occurred seldom in adults before age of 40 and the positive rates did not increased with age (P > 0.05). Although the PBC-specific autoantibodies prevalence in female over age of 40 was 0.62% and 1.32% for women over 60, several folds of that found among males of similar age, there was no statistical difference between female and male at all ages (P > 0.05).

Bottom Line: Fourteen in the 39 individuals positive for AMA at IIF, AMA-M2, anti-gp210, or anti-sp100 had abnormal cholestatic liver functional indices.One definite and 3 probable PBC diagnosis could be made in 4 cases including 3 females and 1 male after half a year.We found a point prevalence rate of PBC among Southern Chinese adults attending for yearly health check-up of 492 cases per million (95% CI, 128 to 1,093) and 1,558 cases per million (95% CI, 294 to 3,815) for women over 40, a finding similar to prevalence reported in other geographical areas.

View Article: PubMed Central - HTML - PubMed

Affiliation: Clinical Laboratory, Guangzhou Women and Children’s Medical Center, 9 Jinsui Road, Guangzhou 510623, China.

ABSTRACT

Background: Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of anti-mitocondrial autoantibodies (AMA) which has an essential role also for diagnosis. In addition, also some anti-nuclear antibodies (ANA) have been shown to be highly specific PBC. The purpose of this study was to assess the prevalence of PBC among the adults referring hospital for annual health check-up in Southern China by screening sera for PBC-specific autoantibodies.

Methods: AMA and ANA were screened in 8,126 adults (mean age 44 ± 15 years, 48% females) by indirect immunofluorenscence (IIF). Positive sera were tested by ELISA/immunoblotting for AMA-M2, anti-sp100 and anti-gp210. A diagnosis of PBC was re-assessed six months after the initial testing.

Results: Out of 8,126 individuals 35 were positive for AMA and 79 positive for ANA. Nineteen, 4, and 3 of the subjects positive for AMA and/or ANA showed reactivity for AMA-M2, anti-sp100 or gp210, respectively, further tested with ELISA/immunoblotting. Fourteen in the 39 individuals positive for AMA at IIF, AMA-M2, anti-gp210, or anti-sp100 had abnormal cholestatic liver functional indices. One definite and 3 probable PBC diagnosis could be made in 4 cases including 3 females and 1 male after half a year.

Conclusions: We found a point prevalence rate of PBC among Southern Chinese adults attending for yearly health check-up of 492 cases per million (95% CI, 128 to 1,093) and 1,558 cases per million (95% CI, 294 to 3,815) for women over 40, a finding similar to prevalence reported in other geographical areas.

Show MeSH
Related in: MedlinePlus