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Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone.

Matsuda H, Imabayashi E, Kuji I, Seto A, Ito K, Kikuta D, Yamada M, Shimano Y, Sato N - BMC Med Imaging (2010)

Bottom Line: SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls.Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons.In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nuclear Medicine, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan. matsudah@saitama-med.ac.jp

ABSTRACT

Background: Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT.

Methods: After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images.

Results: SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution.

Conclusions: The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT.

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Related in: MedlinePlus

Averaged images of contraction maps calculated from high-dimension-warping in the groups of normal controls and MSA-C patients. In the group of MSA-C patients contraction images showed greater absolute values of negative log J indicating severer atrophy in the whole cerebellum and pons than in other areas (arrows). Normal controls did not show severer atrophy in the cerebellum and pons than in other areas.
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Figure 3: Averaged images of contraction maps calculated from high-dimension-warping in the groups of normal controls and MSA-C patients. In the group of MSA-C patients contraction images showed greater absolute values of negative log J indicating severer atrophy in the whole cerebellum and pons than in other areas (arrows). Normal controls did not show severer atrophy in the cerebellum and pons than in other areas.

Mentions: A contraction map and high-dimensionally and conventionally warped SPECT images in a representative MSA-C patient are shown with the MRI findings in Fig. 2. Averaged images of the contraction maps and high-dimensionally and conventionally warped SPECT images in the groups of MSA-C patients and normal controls are shown in Fig. 3 and Fig. 4. In the group of MSA-C patients the contraction map images showed greater absolute values of negative log J in the whole cerebellum and pons than in other areas (Fig. 3). Both high-dimensionally and conventionally warped SPECT images showed decreased perfusion in these areas in the group of MSA-C patients as compared to the normal controls (Fig. 4). Functional volume of cerebellum and pons in the averaged images was compared between high-dimensional and conventional warping using a region of interest template of WFU_PickAtlas http://www.nitrc.org/projects/wfu_pickatlas/. In the group of MSA-C patients conventional warping generated 16% and 24% smaller volume of cerebellum and pons respectively than high-dimension-warping. Maximal perfusion ratios of the whole cerebellum and pons to the whole cerebrum were calculated in averaged images also using a region of in-terest template of WFU_PickAtlas. Conventionally warped and high-dimensionally warped SPECT images in the group of MSA-C patients showed maximal perfusion ratios of 0.81 and 0.83 in the whole cerebellum and of 0.55 and 0.58 in the pons on the average respectively. Conventionally warped and high-dimensionally warped SPECT images in the group of normal controls showed maximal perfusion ratios of 0.90 and 0.88 in the whole cerebellum and of 0.68 and 0.65 in the pons on average, respectively.


Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone.

Matsuda H, Imabayashi E, Kuji I, Seto A, Ito K, Kikuta D, Yamada M, Shimano Y, Sato N - BMC Med Imaging (2010)

Averaged images of contraction maps calculated from high-dimension-warping in the groups of normal controls and MSA-C patients. In the group of MSA-C patients contraction images showed greater absolute values of negative log J indicating severer atrophy in the whole cerebellum and pons than in other areas (arrows). Normal controls did not show severer atrophy in the cerebellum and pons than in other areas.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2927477&req=5

Figure 3: Averaged images of contraction maps calculated from high-dimension-warping in the groups of normal controls and MSA-C patients. In the group of MSA-C patients contraction images showed greater absolute values of negative log J indicating severer atrophy in the whole cerebellum and pons than in other areas (arrows). Normal controls did not show severer atrophy in the cerebellum and pons than in other areas.
Mentions: A contraction map and high-dimensionally and conventionally warped SPECT images in a representative MSA-C patient are shown with the MRI findings in Fig. 2. Averaged images of the contraction maps and high-dimensionally and conventionally warped SPECT images in the groups of MSA-C patients and normal controls are shown in Fig. 3 and Fig. 4. In the group of MSA-C patients the contraction map images showed greater absolute values of negative log J in the whole cerebellum and pons than in other areas (Fig. 3). Both high-dimensionally and conventionally warped SPECT images showed decreased perfusion in these areas in the group of MSA-C patients as compared to the normal controls (Fig. 4). Functional volume of cerebellum and pons in the averaged images was compared between high-dimensional and conventional warping using a region of interest template of WFU_PickAtlas http://www.nitrc.org/projects/wfu_pickatlas/. In the group of MSA-C patients conventional warping generated 16% and 24% smaller volume of cerebellum and pons respectively than high-dimension-warping. Maximal perfusion ratios of the whole cerebellum and pons to the whole cerebrum were calculated in averaged images also using a region of in-terest template of WFU_PickAtlas. Conventionally warped and high-dimensionally warped SPECT images in the group of MSA-C patients showed maximal perfusion ratios of 0.81 and 0.83 in the whole cerebellum and of 0.55 and 0.58 in the pons on the average respectively. Conventionally warped and high-dimensionally warped SPECT images in the group of normal controls showed maximal perfusion ratios of 0.90 and 0.88 in the whole cerebellum and of 0.68 and 0.65 in the pons on average, respectively.

Bottom Line: SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls.Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons.In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nuclear Medicine, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan. matsudah@saitama-med.ac.jp

ABSTRACT

Background: Partial volume effects in atrophied areas should be taken into account when interpreting brain perfusion single photon emission computed tomography (SPECT) images of neurodegenerative diseases. To evaluate both perfusion and atrophy using brain SPECT alone, we developed a new technique applying tensor-based morphometry (TBM) to SPECT.

Methods: After linear spatial normalization of brain perfusion SPECT using 99mTc-ethyl cysteinate dimer (99mTc-ECD) to a Talairach space, high-dimension-warping was done using an original 99mTc-ECD template. Contraction map images calculated from Jacobian determinants and spatially normalized SPECT images using this high-dimension-warping were compared using statistical parametric mapping (SPM2) between two groups of 16 multiple system atrophy of the cerebellar type (MSA-C) patients and 73 age-matched normal controls. This comparison was also performed in conventionally warped SPECT images.

Results: SPM2 demonstrated statistically significant contraction indicating local atrophy and decreased perfusion in the whole cerebellum and pons of MSA-C patients as compared to normal controls. Higher significance for decreased perfusion in these areas was obtained in high-dimension-warping than in conventional warping, possibly due to sufficient spatial normalization to a 99mTc-ECD template in high-dimensional warping of severely atrophied cerebellum and pons. In the present high-dimension-warping, modification of tracer activity remained within 3% of the original tracer distribution.

Conclusions: The present new technique applying TBM to brain SPECT provides information on both perfusion and atrophy at the same time thereby enhancing the role of brain perfusion SPECT.

Show MeSH
Related in: MedlinePlus