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The role of prophylactic anticonvulsants in moderate to severe head injury.

Khan AA, Banerjee A - Int J Emerg Med (2010)

Bottom Line: Post-traumatic seizures cause secondary brain injury, contributing to morbidity and mortality after traumatic brain injury.A structured systematic literature review was performed.There may be a place for prophylactic anticonvulsants in the prophylaxis of early post-traumatic seizures.

View Article: PubMed Central - PubMed

Affiliation: Chase Farm Hospital, The Ridgeway, Enfield, EN2 8JL UK.

ABSTRACT

Background: Post-traumatic seizures cause secondary brain injury, contributing to morbidity and mortality after traumatic brain injury. Seizure activity may be undetectable if the patient is paralysed and ventilated.

Aims: The effect of prophylactic anticonvulsant therapy on the prevention of seizures after moderate to severe traumatic brain injury was studied.

Methods: A structured systematic literature review was performed.

Results: There may be a place for prophylactic anticonvulsants in the prophylaxis of early post-traumatic seizures.

Conclusion: Further randomised controlled trials are needed to firmly establish the benefits of prophylactic anticonvulsants.

No MeSH data available.


Related in: MedlinePlus

Summary of meta-analysis
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Related In: Results  -  Collection


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Fig2: Summary of meta-analysis

Mentions: Two randomised controlled trials (RCTs) were identified (Fig. 1), along with one meta-analysis (Fig. 2) and one systematic review (Fig. 3).Fig. 1


The role of prophylactic anticonvulsants in moderate to severe head injury.

Khan AA, Banerjee A - Int J Emerg Med (2010)

Summary of meta-analysis
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2926870&req=5

Fig2: Summary of meta-analysis
Mentions: Two randomised controlled trials (RCTs) were identified (Fig. 1), along with one meta-analysis (Fig. 2) and one systematic review (Fig. 3).Fig. 1

Bottom Line: Post-traumatic seizures cause secondary brain injury, contributing to morbidity and mortality after traumatic brain injury.A structured systematic literature review was performed.There may be a place for prophylactic anticonvulsants in the prophylaxis of early post-traumatic seizures.

View Article: PubMed Central - PubMed

Affiliation: Chase Farm Hospital, The Ridgeway, Enfield, EN2 8JL UK.

ABSTRACT

Background: Post-traumatic seizures cause secondary brain injury, contributing to morbidity and mortality after traumatic brain injury. Seizure activity may be undetectable if the patient is paralysed and ventilated.

Aims: The effect of prophylactic anticonvulsant therapy on the prevention of seizures after moderate to severe traumatic brain injury was studied.

Methods: A structured systematic literature review was performed.

Results: There may be a place for prophylactic anticonvulsants in the prophylaxis of early post-traumatic seizures.

Conclusion: Further randomised controlled trials are needed to firmly establish the benefits of prophylactic anticonvulsants.

No MeSH data available.


Related in: MedlinePlus