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Nanofibers offer alternative ways to the treatment of skin infections.

Heunis TD, Dicks LM - J. Biomed. Biotechnol. (2010)

Bottom Line: Many pathogens are resistant to antibiotics, rendering conventional treatment less effective.Electrospinning as a technique to prepare nanofibers is discussed.The possibility of using these structures as drug delivery systems is investigated.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, University of Stellenbosch, Matieland, Stellenbosch 7602, South Africa.

ABSTRACT
Injury to the skin causes a breach in the protective layer surrounding the body. Many pathogens are resistant to antibiotics, rendering conventional treatment less effective. This led to the use of alternative antimicrobial compounds, such as silver ions, in skin treatment. In this review nanofibers, and the incorporation of natural antimicrobial compounds in these scaffolds, are discussed as an alternative way to control skin infections. Electrospinning as a technique to prepare nanofibers is discussed. The possibility of using these structures as drug delivery systems is investigated.

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Related in: MedlinePlus

Fibers produced from electrospinning with (a) 1% (w/w) PLLA (the “bead on a string” morphology is clearly visible) and (b) 3% (w/w) PLLA, showing a smooth structure [61].
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fig5: Fibers produced from electrospinning with (a) 1% (w/w) PLLA (the “bead on a string” morphology is clearly visible) and (b) 3% (w/w) PLLA, showing a smooth structure [61].

Mentions: The quality and characteristics of the final product are determined by the temperature, viscosity, elasticity, conductivity, and surface tension of the solution, strength of the electric field, distance between the needle tip and collector, and humidity [49, 73, 74]. Larger fibers (bigger diameter) are obtained by increasing the concentration of the polymer in solution. Polyvinylpyrrolidone (PVP) at 4% (w/w) in a 50 : 50 (w/w) dimethylformamide : ethanol solution is used to produces fibers of 20 nm in diameter [75]. However, PVP at 8% (w/w) in the same solution produces fibers of 50 nm in diameter, and PVP at 10% (w/w) produce fibers of 300 nm in diameter. Electrospinning different concentrations of poly L-lactic acid (PLLA) in a chloroform solution produce nanofibers with different morphologies (Figure 5). PLLA of 1% (w/w) produces a “bead on a string” structure whereas 3% (w/w) PLLA forms nanofibers with a smooth structure [61].


Nanofibers offer alternative ways to the treatment of skin infections.

Heunis TD, Dicks LM - J. Biomed. Biotechnol. (2010)

Fibers produced from electrospinning with (a) 1% (w/w) PLLA (the “bead on a string” morphology is clearly visible) and (b) 3% (w/w) PLLA, showing a smooth structure [61].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2926677&req=5

fig5: Fibers produced from electrospinning with (a) 1% (w/w) PLLA (the “bead on a string” morphology is clearly visible) and (b) 3% (w/w) PLLA, showing a smooth structure [61].
Mentions: The quality and characteristics of the final product are determined by the temperature, viscosity, elasticity, conductivity, and surface tension of the solution, strength of the electric field, distance between the needle tip and collector, and humidity [49, 73, 74]. Larger fibers (bigger diameter) are obtained by increasing the concentration of the polymer in solution. Polyvinylpyrrolidone (PVP) at 4% (w/w) in a 50 : 50 (w/w) dimethylformamide : ethanol solution is used to produces fibers of 20 nm in diameter [75]. However, PVP at 8% (w/w) in the same solution produces fibers of 50 nm in diameter, and PVP at 10% (w/w) produce fibers of 300 nm in diameter. Electrospinning different concentrations of poly L-lactic acid (PLLA) in a chloroform solution produce nanofibers with different morphologies (Figure 5). PLLA of 1% (w/w) produces a “bead on a string” structure whereas 3% (w/w) PLLA forms nanofibers with a smooth structure [61].

Bottom Line: Many pathogens are resistant to antibiotics, rendering conventional treatment less effective.Electrospinning as a technique to prepare nanofibers is discussed.The possibility of using these structures as drug delivery systems is investigated.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, University of Stellenbosch, Matieland, Stellenbosch 7602, South Africa.

ABSTRACT
Injury to the skin causes a breach in the protective layer surrounding the body. Many pathogens are resistant to antibiotics, rendering conventional treatment less effective. This led to the use of alternative antimicrobial compounds, such as silver ions, in skin treatment. In this review nanofibers, and the incorporation of natural antimicrobial compounds in these scaffolds, are discussed as an alternative way to control skin infections. Electrospinning as a technique to prepare nanofibers is discussed. The possibility of using these structures as drug delivery systems is investigated.

Show MeSH
Related in: MedlinePlus