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Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome.

Weijerman ME, van Furth AM, van der Mooren MD, van Weissenbruch MM, Rammeloo L, Broers CJ, Gemke RJ - Eur. J. Pediatr. (2010)

Bottom Line: Atrioventricular septal defect was found in 54%, ventricular septal defect in 33.3% and patent ductus arteriosus in 5.8%.The incidence of PPHN in DS was 5.2%, which is significantly higher than the general population (p < 0.001).In neonates with DS, we found not only a 43% prevalence of CHD, but also a high incidence of PPHN at 5.2%.

View Article: PubMed Central - PubMed

Affiliation: Department of Paediatrics, Subdivision of General Paediatrics and Infectious Diseases, VU University Medical Center, Amsterdam, the Netherlands. weijerman@vumc.nl

ABSTRACT
The aim of this study was to assess the prevalence of congenital heart defects (CHDs) and persistent pulmonary hypertension of the neonate (PPHN) in children with Down syndrome (DS) and to assess its impact on neonatal factors. It was a prospective study of a birth cohort of children with DS born between 2003 and 2006 registered by the Dutch Paediatric Surveillance Unit (DPSU). A CHD occurred in 43% of 482 children with trisomy 21. Atrioventricular septal defect was found in 54%, ventricular septal defect in 33.3% and patent ductus arteriosus in 5.8%. The incidence of PPHN in DS was 5.2%, which is significantly higher than the general population (p < 0.001). The reported mortality in newborns with DS was overall 3.3% and was still significant higher in children with a CHD versus no CHD (5.8% versus 1.5%) (p = 0.008). The presence of CHD in children with DS had no influence on their birth weight, mean gestational age and Apgar score. In neonates with DS, we found not only a 43% prevalence of CHD, but also a high incidence of PPHN at 5.2%. Early recognition of the cardiac condition of neonates with DS seems justified.

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Related in: MedlinePlus

Children with Down syndrome (DS) in the Netherlands born in the period January 1, 2003 to December 31, 2006 with and without congenital heart defect (CHD). Asterisk (*) one child had a combination of trisomy 21 and triple X (0.2%)
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Fig1: Children with Down syndrome (DS) in the Netherlands born in the period January 1, 2003 to December 31, 2006 with and without congenital heart defect (CHD). Asterisk (*) one child had a combination of trisomy 21 and triple X (0.2%)

Mentions: The DPSU registered 820 children with DS who were born between January 1, 2003 and December 31, 2006. A total of 630 questionnaires were returned by the DPSU, and of these, 482 included complete data regarding the cardiac status. A CHD was reported in 207 (43%) of the children with trisomy 21, which is significantly higher than the prevalence of CHD in the Dutch reference population (0.62%, p < 0.001) [12] (Fig. 1).Fig. 1


Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome.

Weijerman ME, van Furth AM, van der Mooren MD, van Weissenbruch MM, Rammeloo L, Broers CJ, Gemke RJ - Eur. J. Pediatr. (2010)

Children with Down syndrome (DS) in the Netherlands born in the period January 1, 2003 to December 31, 2006 with and without congenital heart defect (CHD). Asterisk (*) one child had a combination of trisomy 21 and triple X (0.2%)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2926442&req=5

Fig1: Children with Down syndrome (DS) in the Netherlands born in the period January 1, 2003 to December 31, 2006 with and without congenital heart defect (CHD). Asterisk (*) one child had a combination of trisomy 21 and triple X (0.2%)
Mentions: The DPSU registered 820 children with DS who were born between January 1, 2003 and December 31, 2006. A total of 630 questionnaires were returned by the DPSU, and of these, 482 included complete data regarding the cardiac status. A CHD was reported in 207 (43%) of the children with trisomy 21, which is significantly higher than the prevalence of CHD in the Dutch reference population (0.62%, p < 0.001) [12] (Fig. 1).Fig. 1

Bottom Line: Atrioventricular septal defect was found in 54%, ventricular septal defect in 33.3% and patent ductus arteriosus in 5.8%.The incidence of PPHN in DS was 5.2%, which is significantly higher than the general population (p < 0.001).In neonates with DS, we found not only a 43% prevalence of CHD, but also a high incidence of PPHN at 5.2%.

View Article: PubMed Central - PubMed

Affiliation: Department of Paediatrics, Subdivision of General Paediatrics and Infectious Diseases, VU University Medical Center, Amsterdam, the Netherlands. weijerman@vumc.nl

ABSTRACT
The aim of this study was to assess the prevalence of congenital heart defects (CHDs) and persistent pulmonary hypertension of the neonate (PPHN) in children with Down syndrome (DS) and to assess its impact on neonatal factors. It was a prospective study of a birth cohort of children with DS born between 2003 and 2006 registered by the Dutch Paediatric Surveillance Unit (DPSU). A CHD occurred in 43% of 482 children with trisomy 21. Atrioventricular septal defect was found in 54%, ventricular septal defect in 33.3% and patent ductus arteriosus in 5.8%. The incidence of PPHN in DS was 5.2%, which is significantly higher than the general population (p < 0.001). The reported mortality in newborns with DS was overall 3.3% and was still significant higher in children with a CHD versus no CHD (5.8% versus 1.5%) (p = 0.008). The presence of CHD in children with DS had no influence on their birth weight, mean gestational age and Apgar score. In neonates with DS, we found not only a 43% prevalence of CHD, but also a high incidence of PPHN at 5.2%. Early recognition of the cardiac condition of neonates with DS seems justified.

Show MeSH
Related in: MedlinePlus