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The clinical effective dose of rocuronium for lightwand tracheal intubation after induction with alfentanil, propofol, and low concentrations of sevoflurane.

Park HY, Lee D, Lee KC, Kim SH - Korean J Anesthesiol (2010)

Bottom Line: All patients received alfentanil (10 microg/kg) and propofol (1.5 mg/kg) for the induction of anesthesia.The initial rocuronium dose was 0.5 mg/kg.The rocuronium dose for consecutive patients, determined by Dixon's up-and-down method, was increased or decreased by 0.05 mg/kg according to the result of the previous patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.

ABSTRACT

Background: The aim of this study was to determine the clinical effective dose of rocuronium for tracheal intubation using a lightwand after induction with propofol, alfentanil, and a low concentration of sevoflurane.

Methods: Twenty-eight adults scheduled to undergo elective surgery lasting less than one hour were enrolled in this study. All patients received alfentanil (10 microg/kg) and propofol (1.5 mg/kg) for the induction of anesthesia. Tracheal intubation using a lightwand was attempted 3 minutes after administering rocuronium and mask ventilation with 2 vol% of sevoflurane. The initial rocuronium dose was 0.5 mg/kg. The rocuronium dose for consecutive patients, determined by Dixon's up-and-down method, was increased or decreased by 0.05 mg/kg according to the result of the previous patient. The mean arterial pressure and heart rate were recorded before induction, 1 min before intubation, 1 and 2 min after intubation.

Results: The 50% clinical effective dose (cED(50)) of rocuronium for tracheal intubation using a lightwand was 0.20 +/- 0.05 mg/kg according to Dixon's up and down method. Isotonic regression revealed the cED(50) and cED(95) (95% confidence intervals) to be 0.20 mg/kg (0.10-0.3 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively.

Conclusions: The cED(50) and cED(95) of rocuronium for tracheal intubation using the lightwand were 0.20 mg/kg and 0.35 mg/kg, respectively, after induction with alfentanil, propofol, and a low concentration of sevoflurane.

No MeSH data available.


Related in: MedlinePlus

Pooled-adjacent-violators algorithm (PAVA) response rate. The 50% and 95% clinical effective dose (95% confidence interval) estimated from the PAVA response rate of rocuronium for intubation using the lightwand, were 0.20 mg/kg (0.09-0.30 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively.
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Figure 2: Pooled-adjacent-violators algorithm (PAVA) response rate. The 50% and 95% clinical effective dose (95% confidence interval) estimated from the PAVA response rate of rocuronium for intubation using the lightwand, were 0.20 mg/kg (0.09-0.30 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively.

Mentions: The dose of rocuronium for successful tracheal intubation using the lightwand in 50% of patients (cED50) was 0.20 ± 0.05 mg/kg according to Dixon's up and down method (Fig. 1). Isotonic regression, which was estimated from the PAVA rate, revealed an cED50 and cED95 (95% CI) of rocuronium 0.20 mg/kg (0.09-0.30 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively (Fig. 2).


The clinical effective dose of rocuronium for lightwand tracheal intubation after induction with alfentanil, propofol, and low concentrations of sevoflurane.

Park HY, Lee D, Lee KC, Kim SH - Korean J Anesthesiol (2010)

Pooled-adjacent-violators algorithm (PAVA) response rate. The 50% and 95% clinical effective dose (95% confidence interval) estimated from the PAVA response rate of rocuronium for intubation using the lightwand, were 0.20 mg/kg (0.09-0.30 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2926434&req=5

Figure 2: Pooled-adjacent-violators algorithm (PAVA) response rate. The 50% and 95% clinical effective dose (95% confidence interval) estimated from the PAVA response rate of rocuronium for intubation using the lightwand, were 0.20 mg/kg (0.09-0.30 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively.
Mentions: The dose of rocuronium for successful tracheal intubation using the lightwand in 50% of patients (cED50) was 0.20 ± 0.05 mg/kg according to Dixon's up and down method (Fig. 1). Isotonic regression, which was estimated from the PAVA rate, revealed an cED50 and cED95 (95% CI) of rocuronium 0.20 mg/kg (0.09-0.30 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively (Fig. 2).

Bottom Line: All patients received alfentanil (10 microg/kg) and propofol (1.5 mg/kg) for the induction of anesthesia.The initial rocuronium dose was 0.5 mg/kg.The rocuronium dose for consecutive patients, determined by Dixon's up-and-down method, was increased or decreased by 0.05 mg/kg according to the result of the previous patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.

ABSTRACT

Background: The aim of this study was to determine the clinical effective dose of rocuronium for tracheal intubation using a lightwand after induction with propofol, alfentanil, and a low concentration of sevoflurane.

Methods: Twenty-eight adults scheduled to undergo elective surgery lasting less than one hour were enrolled in this study. All patients received alfentanil (10 microg/kg) and propofol (1.5 mg/kg) for the induction of anesthesia. Tracheal intubation using a lightwand was attempted 3 minutes after administering rocuronium and mask ventilation with 2 vol% of sevoflurane. The initial rocuronium dose was 0.5 mg/kg. The rocuronium dose for consecutive patients, determined by Dixon's up-and-down method, was increased or decreased by 0.05 mg/kg according to the result of the previous patient. The mean arterial pressure and heart rate were recorded before induction, 1 min before intubation, 1 and 2 min after intubation.

Results: The 50% clinical effective dose (cED(50)) of rocuronium for tracheal intubation using a lightwand was 0.20 +/- 0.05 mg/kg according to Dixon's up and down method. Isotonic regression revealed the cED(50) and cED(95) (95% confidence intervals) to be 0.20 mg/kg (0.10-0.3 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively.

Conclusions: The cED(50) and cED(95) of rocuronium for tracheal intubation using the lightwand were 0.20 mg/kg and 0.35 mg/kg, respectively, after induction with alfentanil, propofol, and a low concentration of sevoflurane.

No MeSH data available.


Related in: MedlinePlus