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First nationwide survey on cardiovascular risk factors in Grand-Duchy of Luxembourg (ORISCAV-LUX).

Alkerwi A, Sauvageot N, Donneau AF, Lair ML, Couffignal S, Beissel J, Delagardelle C, Wagener Y, Albert A, Guillaume M - BMC Public Health (2010)

Bottom Line: There was a significant difference in the prevalence of hypertension and of lipid disorders by geographic region of birth.The population-based ORISCAV-LUX survey revealed a high prevalence of potentially modifiable and treatable cardiovascular risk factors among apparently healthy subjects; significant gender and age-specific differences were seen not only for single but also for combined risk factors.From a public health perspective, these preliminary findings stress the urgent need for early routine health examinations, preventive interventions and lifestyle behavioural changes, even in young asymptomatic adults, to decrease cardiovascular morbidity and mortality in Luxembourg.

View Article: PubMed Central - HTML - PubMed

Affiliation: Centre de Recherche Public Santé, Centre d'Etudes en Santé, Grand-Duchy of Luxembourg. alaa.alkerwi@crp-sante.lu

ABSTRACT

Background: The ORISCAV-LUX study is the first baseline survey of an on-going cardiovascular health monitoring programme in Grand-Duchy of Luxembourg. The main objectives of the present manuscript were 1) to describe the study design and conduct, and 2) to present the salient outcomes of the study, in particular the prevalence of the potentially modifiable and treatable cardiovascular disease risk factors in the adult population residing in Luxembourg.

Method: ORISCAV-LUX is a cross-sectional study based on a random sample of 4496 subjects, stratified by gender, age categories and district, drawn from the national insurance registry of 18-69 years aged Luxembourg residents, assuming a response rate of 30% and a proportion of 5% of institutionalized subjects in each stratum. The cardiovascular health status was assessed by means of a self-administered questionnaire, clinical and anthropometric measures, as well as by blood, urine and hair examinations. The potentially modifiable and treatable risk factors studied included smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. Both univariate and multivariate statistical analyses used weighted methods to account for the stratified sampling scheme.

Results: A total of 1432 subjects took part in the survey, yielding a participation rate of 32.2%. This figure is higher than the minimal sample size of 1285 subjects as estimated by power calculation. The most predominant cardiovascular risk factors were dyslipidemia (69.9%), hypertension (34.5%), smoking (22.3%), and obesity (20.9%), while diabetes amounted 4.4%. All prevalence rates increased with age (except smoking) with marked gender differences (except diabetes). There was a significant difference in the prevalence of hypertension and of lipid disorders by geographic region of birth. The proportion of subjects cumulating two or more cardiovascular risk factors increased remarkably with age and was more predominant in men than in women (P<0.0001). Only 14.7% of men and 23.1% of women were free of any cardiovascular risk factor. High prevalence of non-treated CVRF, notably for hypertension and dyslipidemia, were observed in the study population.

Conclusion: The population-based ORISCAV-LUX survey revealed a high prevalence of potentially modifiable and treatable cardiovascular risk factors among apparently healthy subjects; significant gender and age-specific differences were seen not only for single but also for combined risk factors. From a public health perspective, these preliminary findings stress the urgent need for early routine health examinations, preventive interventions and lifestyle behavioural changes, even in young asymptomatic adults, to decrease cardiovascular morbidity and mortality in Luxembourg.

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Distribution of the number of CVRF per subject globally and by gender in the ORISCAV-LUX study.
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Figure 1: Distribution of the number of CVRF per subject globally and by gender in the ORISCAV-LUX study.

Mentions: The distribution of the number of CVRF affecting each subject is displayed in Figure 1, globally and by gender. It is seen that 35% of the participants presented only one CVRF, 29.3% presented 2 CVRF, and 16.9% presented 3 and more CVRF. Only 18.9% of the subjects (14.7% of men and 23.1% of women) were free of any CVRF. Among subjects presenting only one CVRF, 75% had lipid disorder, 11.4% were regular smokers and 9.5% suffered hypertension. For individuals with 2 CVRF, the most frequent combinations were lipid disorder and hypertension (53%), lipid disorder and smoking (24.2%), lipid disorder and obesity (14.4%). In subjects with 3 CVRF, the "lipid disorder, hypertension and obesity" combination was found in 64.9% of the cases, while the "lipid disorder, hypertension and current smoking" profile was observed in 13.9% of the subjects. Finally, in subjects with 4 CVRF, it was found that 55.6% of them were exempt of current smoking and 38.9% were exempt of diabetes. When analysing the number of CVRF per participant with respect to age and gender, it was observed that this number increased significantly with age (P < 0.0001), and was more predominant in men than in women (P < 0.0001). The interaction term between age and gender was not significant.


First nationwide survey on cardiovascular risk factors in Grand-Duchy of Luxembourg (ORISCAV-LUX).

Alkerwi A, Sauvageot N, Donneau AF, Lair ML, Couffignal S, Beissel J, Delagardelle C, Wagener Y, Albert A, Guillaume M - BMC Public Health (2010)

Distribution of the number of CVRF per subject globally and by gender in the ORISCAV-LUX study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2925827&req=5

Figure 1: Distribution of the number of CVRF per subject globally and by gender in the ORISCAV-LUX study.
Mentions: The distribution of the number of CVRF affecting each subject is displayed in Figure 1, globally and by gender. It is seen that 35% of the participants presented only one CVRF, 29.3% presented 2 CVRF, and 16.9% presented 3 and more CVRF. Only 18.9% of the subjects (14.7% of men and 23.1% of women) were free of any CVRF. Among subjects presenting only one CVRF, 75% had lipid disorder, 11.4% were regular smokers and 9.5% suffered hypertension. For individuals with 2 CVRF, the most frequent combinations were lipid disorder and hypertension (53%), lipid disorder and smoking (24.2%), lipid disorder and obesity (14.4%). In subjects with 3 CVRF, the "lipid disorder, hypertension and obesity" combination was found in 64.9% of the cases, while the "lipid disorder, hypertension and current smoking" profile was observed in 13.9% of the subjects. Finally, in subjects with 4 CVRF, it was found that 55.6% of them were exempt of current smoking and 38.9% were exempt of diabetes. When analysing the number of CVRF per participant with respect to age and gender, it was observed that this number increased significantly with age (P < 0.0001), and was more predominant in men than in women (P < 0.0001). The interaction term between age and gender was not significant.

Bottom Line: There was a significant difference in the prevalence of hypertension and of lipid disorders by geographic region of birth.The population-based ORISCAV-LUX survey revealed a high prevalence of potentially modifiable and treatable cardiovascular risk factors among apparently healthy subjects; significant gender and age-specific differences were seen not only for single but also for combined risk factors.From a public health perspective, these preliminary findings stress the urgent need for early routine health examinations, preventive interventions and lifestyle behavioural changes, even in young asymptomatic adults, to decrease cardiovascular morbidity and mortality in Luxembourg.

View Article: PubMed Central - HTML - PubMed

Affiliation: Centre de Recherche Public Santé, Centre d'Etudes en Santé, Grand-Duchy of Luxembourg. alaa.alkerwi@crp-sante.lu

ABSTRACT

Background: The ORISCAV-LUX study is the first baseline survey of an on-going cardiovascular health monitoring programme in Grand-Duchy of Luxembourg. The main objectives of the present manuscript were 1) to describe the study design and conduct, and 2) to present the salient outcomes of the study, in particular the prevalence of the potentially modifiable and treatable cardiovascular disease risk factors in the adult population residing in Luxembourg.

Method: ORISCAV-LUX is a cross-sectional study based on a random sample of 4496 subjects, stratified by gender, age categories and district, drawn from the national insurance registry of 18-69 years aged Luxembourg residents, assuming a response rate of 30% and a proportion of 5% of institutionalized subjects in each stratum. The cardiovascular health status was assessed by means of a self-administered questionnaire, clinical and anthropometric measures, as well as by blood, urine and hair examinations. The potentially modifiable and treatable risk factors studied included smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. Both univariate and multivariate statistical analyses used weighted methods to account for the stratified sampling scheme.

Results: A total of 1432 subjects took part in the survey, yielding a participation rate of 32.2%. This figure is higher than the minimal sample size of 1285 subjects as estimated by power calculation. The most predominant cardiovascular risk factors were dyslipidemia (69.9%), hypertension (34.5%), smoking (22.3%), and obesity (20.9%), while diabetes amounted 4.4%. All prevalence rates increased with age (except smoking) with marked gender differences (except diabetes). There was a significant difference in the prevalence of hypertension and of lipid disorders by geographic region of birth. The proportion of subjects cumulating two or more cardiovascular risk factors increased remarkably with age and was more predominant in men than in women (P<0.0001). Only 14.7% of men and 23.1% of women were free of any cardiovascular risk factor. High prevalence of non-treated CVRF, notably for hypertension and dyslipidemia, were observed in the study population.

Conclusion: The population-based ORISCAV-LUX survey revealed a high prevalence of potentially modifiable and treatable cardiovascular risk factors among apparently healthy subjects; significant gender and age-specific differences were seen not only for single but also for combined risk factors. From a public health perspective, these preliminary findings stress the urgent need for early routine health examinations, preventive interventions and lifestyle behavioural changes, even in young asymptomatic adults, to decrease cardiovascular morbidity and mortality in Luxembourg.

Show MeSH
Related in: MedlinePlus