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Bilateral somatosensory evoked potentials following intermittent theta-burst repetitive transcranial magnetic stimulation.

Premji A, Ziluk A, Nelson AJ - BMC Neurosci (2010)

Bottom Line: Compared to pre-iTBS, the amplitude of cortical potential N20/P25 was significantly increased for 5 minutes from non-stimulated SI and for 15 to 25 minutes from stimulated SI.We conclude that iTBS increases the cortical excitability of SI bilaterally and does not alter thalamocortical afferent input to SI.ITBS may provide one avenue to induce cortical plasticity in the somatosensory cortex.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Kinesiology, University of Waterloo, Waterloo, Canada.

ABSTRACT

Background: Intermittent theta-burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation that may alter cortical excitability in the primary somatosensory cortex (SI). The present study investigated the effects of iTBS on subcortical and early cortical somatosensory evoked potentials (SEPs) recorded over left, iTBS stimulated SI and the right-hemisphere non-stimulated SI. SEPs were recorded before and at 5, 15, and 25 minutes following iTBS.

Results: Compared to pre-iTBS, the amplitude of cortical potential N20/P25 was significantly increased for 5 minutes from non-stimulated SI and for 15 to 25 minutes from stimulated SI. Subcortical potentials recorded bilaterally remained unaltered following iTBS.

Conclusion: We conclude that iTBS increases the cortical excitability of SI bilaterally and does not alter thalamocortical afferent input to SI. ITBS may provide one avenue to induce cortical plasticity in the somatosensory cortex.

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Left-hemisphere SEPs. Group averaged SEPs recorded from iTBS stimulated left-hemisphere SI. A. P18/N20 peak-to-peak group averaged data (n = 11) before (pre) and following (post) iTBS at 5 min (post 5) 15 min (post 15) and 25 minutes (post 25). B. N20/P25 peak-to-peak group averaged data pre and post-iTBS (n = 11). SEP amplitude is significantly greater at 15 and 25 min following iTBS (p < 0.05). Error bars represent standard error of the mean.
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Figure 1: Left-hemisphere SEPs. Group averaged SEPs recorded from iTBS stimulated left-hemisphere SI. A. P18/N20 peak-to-peak group averaged data (n = 11) before (pre) and following (post) iTBS at 5 min (post 5) 15 min (post 15) and 25 minutes (post 25). B. N20/P25 peak-to-peak group averaged data pre and post-iTBS (n = 11). SEP amplitude is significantly greater at 15 and 25 min following iTBS (p < 0.05). Error bars represent standard error of the mean.

Mentions: For the P18/N20 potential, there was no significant main effect of TIME (F(3, 30) = 0.19, p = 0.90) and SEP amplitudes were not significantly different following iTBS. Figure 1A plots the group averaged peak-to-peak amplitude (n = 11) of the subcortical P18/N20 SEP before and after iTBS. For the N20/P25 peak-to-peak amplitude, ANOVA revealed a main effect of TIME (F(3, 30) = 3.38, p = 0.03). Figure 1B plots the group averaged peak-to-peak N20/P25 amplitude (n = 11). Compared to pre-iTBS, the N20/P25 was significantly greater at 15 (p = 0.013) and 25 minutes post-iTBS (p = 0.007).


Bilateral somatosensory evoked potentials following intermittent theta-burst repetitive transcranial magnetic stimulation.

Premji A, Ziluk A, Nelson AJ - BMC Neurosci (2010)

Left-hemisphere SEPs. Group averaged SEPs recorded from iTBS stimulated left-hemisphere SI. A. P18/N20 peak-to-peak group averaged data (n = 11) before (pre) and following (post) iTBS at 5 min (post 5) 15 min (post 15) and 25 minutes (post 25). B. N20/P25 peak-to-peak group averaged data pre and post-iTBS (n = 11). SEP amplitude is significantly greater at 15 and 25 min following iTBS (p < 0.05). Error bars represent standard error of the mean.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
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Figure 1: Left-hemisphere SEPs. Group averaged SEPs recorded from iTBS stimulated left-hemisphere SI. A. P18/N20 peak-to-peak group averaged data (n = 11) before (pre) and following (post) iTBS at 5 min (post 5) 15 min (post 15) and 25 minutes (post 25). B. N20/P25 peak-to-peak group averaged data pre and post-iTBS (n = 11). SEP amplitude is significantly greater at 15 and 25 min following iTBS (p < 0.05). Error bars represent standard error of the mean.
Mentions: For the P18/N20 potential, there was no significant main effect of TIME (F(3, 30) = 0.19, p = 0.90) and SEP amplitudes were not significantly different following iTBS. Figure 1A plots the group averaged peak-to-peak amplitude (n = 11) of the subcortical P18/N20 SEP before and after iTBS. For the N20/P25 peak-to-peak amplitude, ANOVA revealed a main effect of TIME (F(3, 30) = 3.38, p = 0.03). Figure 1B plots the group averaged peak-to-peak N20/P25 amplitude (n = 11). Compared to pre-iTBS, the N20/P25 was significantly greater at 15 (p = 0.013) and 25 minutes post-iTBS (p = 0.007).

Bottom Line: Compared to pre-iTBS, the amplitude of cortical potential N20/P25 was significantly increased for 5 minutes from non-stimulated SI and for 15 to 25 minutes from stimulated SI.We conclude that iTBS increases the cortical excitability of SI bilaterally and does not alter thalamocortical afferent input to SI.ITBS may provide one avenue to induce cortical plasticity in the somatosensory cortex.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Kinesiology, University of Waterloo, Waterloo, Canada.

ABSTRACT

Background: Intermittent theta-burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation that may alter cortical excitability in the primary somatosensory cortex (SI). The present study investigated the effects of iTBS on subcortical and early cortical somatosensory evoked potentials (SEPs) recorded over left, iTBS stimulated SI and the right-hemisphere non-stimulated SI. SEPs were recorded before and at 5, 15, and 25 minutes following iTBS.

Results: Compared to pre-iTBS, the amplitude of cortical potential N20/P25 was significantly increased for 5 minutes from non-stimulated SI and for 15 to 25 minutes from stimulated SI. Subcortical potentials recorded bilaterally remained unaltered following iTBS.

Conclusion: We conclude that iTBS increases the cortical excitability of SI bilaterally and does not alter thalamocortical afferent input to SI. ITBS may provide one avenue to induce cortical plasticity in the somatosensory cortex.

Show MeSH
Related in: MedlinePlus