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C-reactive protein levels: a prognostic marker for patients with head and neck cancer?

Kruse AL, Luebbers HT, Grätz KW - Head Neck Oncol (2010)

Bottom Line: In 278 patients with oral cancer, preoperative CRP levels were compared with development of recurrence and metastasis.No significant correlation could be found between elevated CRP levels and metastasis (p = 0.468) or recurrence (p = 0.137).Our findings do not appear to support a correlation between preoperative CRP levels and development of recurrence or metastases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Craniomaxillofacial and Oral Surgery, University Hospital Zurich, Zurich, Switzerland. astridkruse@gmx.ch

ABSTRACT

Background: Recent advances in understanding complex tumor interactions have led to the discovery of an association between inflammation and cancer, in particular for colon and lung cancer, but only a very few have dealt with oral cancer. Therefore, the aim of the current study was to investigate the significance of preoperative C-reactive protein (CRP) levels as a parameter for development of lymph node metastases or recurrence.

Materials and methods: In 278 patients with oral cancer, preoperative CRP levels were compared with development of recurrence and metastasis.

Results: In 27 patients from the normal CRP group, and in 21 patients from the elevated CRP group, local recurrence was observed. Concerning lymph node metastases, 37 patients were in the normal group and 9 patients in the elevated CRP group. No significant correlation could be found between elevated CRP levels and metastasis (p = 0.468) or recurrence (p = 0.137).

Conclusion: Our findings do not appear to support a correlation between preoperative CRP levels and development of recurrence or metastases. In further studies, CRP levels in precancerous lesions and in Human Papilloma Virus (HPV) positive patients with oral squamous cell carcinoma (SCC) should be studied.

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Kaplan-Meier analysis of development of recurrence in regard to CRP level.
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Figure 5: Kaplan-Meier analysis of development of recurrence in regard to CRP level.

Mentions: In 27 patients in the normal CRP group and in 21 patients belonging to the elevated CRP group, local recurrence was observed. Concerning lymph node metastases, 37 patients were in the normal group and 9 patients in the elevated CRP. No significant correlation was found neither for development of metastasis (p = 0.468) (Fig. 4) nor for recurrence (p = 0.137) (Fig. 5).


C-reactive protein levels: a prognostic marker for patients with head and neck cancer?

Kruse AL, Luebbers HT, Grätz KW - Head Neck Oncol (2010)

Kaplan-Meier analysis of development of recurrence in regard to CRP level.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2921363&req=5

Figure 5: Kaplan-Meier analysis of development of recurrence in regard to CRP level.
Mentions: In 27 patients in the normal CRP group and in 21 patients belonging to the elevated CRP group, local recurrence was observed. Concerning lymph node metastases, 37 patients were in the normal group and 9 patients in the elevated CRP. No significant correlation was found neither for development of metastasis (p = 0.468) (Fig. 4) nor for recurrence (p = 0.137) (Fig. 5).

Bottom Line: In 278 patients with oral cancer, preoperative CRP levels were compared with development of recurrence and metastasis.No significant correlation could be found between elevated CRP levels and metastasis (p = 0.468) or recurrence (p = 0.137).Our findings do not appear to support a correlation between preoperative CRP levels and development of recurrence or metastases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Craniomaxillofacial and Oral Surgery, University Hospital Zurich, Zurich, Switzerland. astridkruse@gmx.ch

ABSTRACT

Background: Recent advances in understanding complex tumor interactions have led to the discovery of an association between inflammation and cancer, in particular for colon and lung cancer, but only a very few have dealt with oral cancer. Therefore, the aim of the current study was to investigate the significance of preoperative C-reactive protein (CRP) levels as a parameter for development of lymph node metastases or recurrence.

Materials and methods: In 278 patients with oral cancer, preoperative CRP levels were compared with development of recurrence and metastasis.

Results: In 27 patients from the normal CRP group, and in 21 patients from the elevated CRP group, local recurrence was observed. Concerning lymph node metastases, 37 patients were in the normal group and 9 patients in the elevated CRP group. No significant correlation could be found between elevated CRP levels and metastasis (p = 0.468) or recurrence (p = 0.137).

Conclusion: Our findings do not appear to support a correlation between preoperative CRP levels and development of recurrence or metastases. In further studies, CRP levels in precancerous lesions and in Human Papilloma Virus (HPV) positive patients with oral squamous cell carcinoma (SCC) should be studied.

Show MeSH
Related in: MedlinePlus