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Selective laser trabeculoplasty reduces mean IOP and IOP variation in normal tension glaucoma patients.

El Mallah MK, Walsh MM, Stinnett SS, Asrani SG - Clin Ophthalmol (2010)

Bottom Line: The average of the mean pre-operative IOP measurements was 14.3 +/- 2.6 mmHg compared to 12.2 +/- 1.7 mmHg (P < 0.001) post-operatively.The mean pre-operative standard deviation was 1.9 +/- 0.9 mmHg compared to 1.0 +/- 0.6 mmHg (P = 0.002) post-operatively while the mean IOP range prior to treatment was 4.5 +/- 2.5 mmHg compared to 2.5 +/- 1.9 mmHg (P = 0.017) after treatment.In this pilot study, SLT was found to lower mean IOP and intervisit IOP variation in NTG patients.

View Article: PubMed Central - PubMed

Affiliation: Ocala Eye, Ocala, Florida, USA. elmallah@post.harvard.edu

ABSTRACT

Purpose: To evaluate the effect of selective laser trabeculoplasty (SLT) in normal tension glaucoma (NTG) patients.

Patients and methods: A retrospective review was performed of NTG patients who had undergone SLT at the Duke University Eye Center between 12/2002 and 7/2005. For each eye of each patient at pre-laser and post-laser time points, the IOP measurements were summarized by mean, standard deviation, and range. Then for each of these descriptive statistics, the differences between pre-laser and post-laser values were obtained. Statistical analysis was performed using a random effects model.

Main outcome measures: difference in mean IOP, standard deviation of IOP, and range of IOP.

Results: Thirty-one eyes of 18 patients were included for analysis. The average of the mean pre-operative IOP measurements was 14.3 +/- 2.6 mmHg compared to 12.2 +/- 1.7 mmHg (P < 0.001) post-operatively. The mean pre-operative standard deviation was 1.9 +/- 0.9 mmHg compared to 1.0 +/- 0.6 mmHg (P = 0.002) post-operatively while the mean IOP range prior to treatment was 4.5 +/- 2.5 mmHg compared to 2.5 +/- 1.9 mmHg (P = 0.017) after treatment.

Conclusion: In this pilot study, SLT was found to lower mean IOP and intervisit IOP variation in NTG patients. Given the importance of IOP variation and its association with glaucoma progression, measurement of IOP variation following treatment with SLT may be considered.

No MeSH data available.


Related in: MedlinePlus

Boxplot of mean IOP pre-SLT vs post-SLT in NTG patients.
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f1-opth-4-889: Boxplot of mean IOP pre-SLT vs post-SLT in NTG patients.

Mentions: The average of the mean pre-laser IOP measurements was 14.3 ± 2.6 mmHg while the average of the mean post-laser IOP measurements was 12.2 ± 1.7 mmHg (P < 0.001) (Figure 1). The mean pre-laser IOP standard deviation was 1.9 ± 0.9 mmHg while the mean standard deviation after laser was 1.0 ± 0.6 mmHg (P = 0.002) (Figure 2). The mean IOP range prior to laser treatment was 4.5 ± 2.5 mmHg. After laser treatment, the mean IOP range decreased to 2.5 ± 1.9 mmHg (P = 0.017) (Figure 3).


Selective laser trabeculoplasty reduces mean IOP and IOP variation in normal tension glaucoma patients.

El Mallah MK, Walsh MM, Stinnett SS, Asrani SG - Clin Ophthalmol (2010)

Boxplot of mean IOP pre-SLT vs post-SLT in NTG patients.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2921297&req=5

f1-opth-4-889: Boxplot of mean IOP pre-SLT vs post-SLT in NTG patients.
Mentions: The average of the mean pre-laser IOP measurements was 14.3 ± 2.6 mmHg while the average of the mean post-laser IOP measurements was 12.2 ± 1.7 mmHg (P < 0.001) (Figure 1). The mean pre-laser IOP standard deviation was 1.9 ± 0.9 mmHg while the mean standard deviation after laser was 1.0 ± 0.6 mmHg (P = 0.002) (Figure 2). The mean IOP range prior to laser treatment was 4.5 ± 2.5 mmHg. After laser treatment, the mean IOP range decreased to 2.5 ± 1.9 mmHg (P = 0.017) (Figure 3).

Bottom Line: The average of the mean pre-operative IOP measurements was 14.3 +/- 2.6 mmHg compared to 12.2 +/- 1.7 mmHg (P < 0.001) post-operatively.The mean pre-operative standard deviation was 1.9 +/- 0.9 mmHg compared to 1.0 +/- 0.6 mmHg (P = 0.002) post-operatively while the mean IOP range prior to treatment was 4.5 +/- 2.5 mmHg compared to 2.5 +/- 1.9 mmHg (P = 0.017) after treatment.In this pilot study, SLT was found to lower mean IOP and intervisit IOP variation in NTG patients.

View Article: PubMed Central - PubMed

Affiliation: Ocala Eye, Ocala, Florida, USA. elmallah@post.harvard.edu

ABSTRACT

Purpose: To evaluate the effect of selective laser trabeculoplasty (SLT) in normal tension glaucoma (NTG) patients.

Patients and methods: A retrospective review was performed of NTG patients who had undergone SLT at the Duke University Eye Center between 12/2002 and 7/2005. For each eye of each patient at pre-laser and post-laser time points, the IOP measurements were summarized by mean, standard deviation, and range. Then for each of these descriptive statistics, the differences between pre-laser and post-laser values were obtained. Statistical analysis was performed using a random effects model.

Main outcome measures: difference in mean IOP, standard deviation of IOP, and range of IOP.

Results: Thirty-one eyes of 18 patients were included for analysis. The average of the mean pre-operative IOP measurements was 14.3 +/- 2.6 mmHg compared to 12.2 +/- 1.7 mmHg (P < 0.001) post-operatively. The mean pre-operative standard deviation was 1.9 +/- 0.9 mmHg compared to 1.0 +/- 0.6 mmHg (P = 0.002) post-operatively while the mean IOP range prior to treatment was 4.5 +/- 2.5 mmHg compared to 2.5 +/- 1.9 mmHg (P = 0.017) after treatment.

Conclusion: In this pilot study, SLT was found to lower mean IOP and intervisit IOP variation in NTG patients. Given the importance of IOP variation and its association with glaucoma progression, measurement of IOP variation following treatment with SLT may be considered.

No MeSH data available.


Related in: MedlinePlus