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Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent.

Reimer P, Vosshenrich R - Biologics (2010)

Bottom Line: Gadoxetic acid enhances hepatocyte-containing lesions and improves detection of lesions devoid of normal hepatocytes, such as metastases.Innovative rapid MR acquisition techniques with near isotropic 3D pulse sequences with fat saturation parallel the technical progress made by multidetector computed tomography combined with an impressive improvement in tumor-liver contrast when used for gadoxetic acid-enhanced MRI.The purpose of this review is to provide an overview of the development, clinical testing, and applications of this novel MR contrast agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Klinikum Karlsruhe, Karlsruhe, Germany;

ABSTRACT
The value of cross-sectional liver imaging is evaluated by the accuracy, sensitivity, and specificity of the specific imaging technique. Magnetic resonance imaging (MRI) has become a key technique for the characterization and detection of focal and diffuse liver disease. More recently, gadoxetic acid, the hepatocyte-specific MR contrast agent, was clinically approved and introduced in many countries. Gadoxetic acid may be considered a "molecular imaging" probe because the compound is actively taken into hepatocytes via the ATP-dependent organic anion transport system in the plasma membrane for the hepatic uptake. The transport of gadoxetic acid from the cytoplasm to the bile is mainly determined by the capacity of the transport protein glutathione-S-transferase. Gadoxetic acid enhances hepatocyte-containing lesions and improves detection of lesions devoid of normal hepatocytes, such as metastases. Innovative rapid MR acquisition techniques with near isotropic 3D pulse sequences with fat saturation parallel the technical progress made by multidetector computed tomography combined with an impressive improvement in tumor-liver contrast when used for gadoxetic acid-enhanced MRI. The purpose of this review is to provide an overview of the development, clinical testing, and applications of this novel MR contrast agent.

No MeSH data available.


Related in: MedlinePlus

Well-differentiated hepatocellular carcinoma (HCC). Plain T1-weighted spoiled 2D gradient echo (GRE) A) T2-weighted half-Fourier acquisition single-shot turbo spin-echo (HASTE) B) hepatocellular phase gadoxetic acid-enhanced fat-suppressed (FS) T1-weighted spoiled 3D GRE C) and gross pathology D) in the axial plane. A small liver mass in S4b is faintly visible on unenhanced sequences showing characteristics of a HCC nodule such as a rim on T1-weighted magnetic resonance imaging (MRI) (A). Gadoxetic acid-enhanced MRI shows an enhancing lesion mimicking a benign lesion based on uptake into the well-differentiated HCC confirmed at surgery. Gross pathology is courtesy of Prof Thomas Rüdiger.
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f3-btt-4-199: Well-differentiated hepatocellular carcinoma (HCC). Plain T1-weighted spoiled 2D gradient echo (GRE) A) T2-weighted half-Fourier acquisition single-shot turbo spin-echo (HASTE) B) hepatocellular phase gadoxetic acid-enhanced fat-suppressed (FS) T1-weighted spoiled 3D GRE C) and gross pathology D) in the axial plane. A small liver mass in S4b is faintly visible on unenhanced sequences showing characteristics of a HCC nodule such as a rim on T1-weighted magnetic resonance imaging (MRI) (A). Gadoxetic acid-enhanced MRI shows an enhancing lesion mimicking a benign lesion based on uptake into the well-differentiated HCC confirmed at surgery. Gross pathology is courtesy of Prof Thomas Rüdiger.

Mentions: Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide (Figures 3 and 4). Most of the HCCs that are associated with hepatitis B virus (HBV) occur in patients who have hepatitis B infection during most of their lives, also called chronic hepatitis B. The development of HCC is also associated with chronic hepatitis C virus (HCV). Most of the patients who develop HCC as a result of HCV will have liver cirrhosis. The average time to develop HCC after initial exposure to HCV is about 28 years and usually about 8–10 years after the development of liver cirrhosis. The way in which HCV causes HCC is not well understood.4


Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent.

Reimer P, Vosshenrich R - Biologics (2010)

Well-differentiated hepatocellular carcinoma (HCC). Plain T1-weighted spoiled 2D gradient echo (GRE) A) T2-weighted half-Fourier acquisition single-shot turbo spin-echo (HASTE) B) hepatocellular phase gadoxetic acid-enhanced fat-suppressed (FS) T1-weighted spoiled 3D GRE C) and gross pathology D) in the axial plane. A small liver mass in S4b is faintly visible on unenhanced sequences showing characteristics of a HCC nodule such as a rim on T1-weighted magnetic resonance imaging (MRI) (A). Gadoxetic acid-enhanced MRI shows an enhancing lesion mimicking a benign lesion based on uptake into the well-differentiated HCC confirmed at surgery. Gross pathology is courtesy of Prof Thomas Rüdiger.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2921257&req=5

f3-btt-4-199: Well-differentiated hepatocellular carcinoma (HCC). Plain T1-weighted spoiled 2D gradient echo (GRE) A) T2-weighted half-Fourier acquisition single-shot turbo spin-echo (HASTE) B) hepatocellular phase gadoxetic acid-enhanced fat-suppressed (FS) T1-weighted spoiled 3D GRE C) and gross pathology D) in the axial plane. A small liver mass in S4b is faintly visible on unenhanced sequences showing characteristics of a HCC nodule such as a rim on T1-weighted magnetic resonance imaging (MRI) (A). Gadoxetic acid-enhanced MRI shows an enhancing lesion mimicking a benign lesion based on uptake into the well-differentiated HCC confirmed at surgery. Gross pathology is courtesy of Prof Thomas Rüdiger.
Mentions: Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide (Figures 3 and 4). Most of the HCCs that are associated with hepatitis B virus (HBV) occur in patients who have hepatitis B infection during most of their lives, also called chronic hepatitis B. The development of HCC is also associated with chronic hepatitis C virus (HCV). Most of the patients who develop HCC as a result of HCV will have liver cirrhosis. The average time to develop HCC after initial exposure to HCV is about 28 years and usually about 8–10 years after the development of liver cirrhosis. The way in which HCV causes HCC is not well understood.4

Bottom Line: Gadoxetic acid enhances hepatocyte-containing lesions and improves detection of lesions devoid of normal hepatocytes, such as metastases.Innovative rapid MR acquisition techniques with near isotropic 3D pulse sequences with fat saturation parallel the technical progress made by multidetector computed tomography combined with an impressive improvement in tumor-liver contrast when used for gadoxetic acid-enhanced MRI.The purpose of this review is to provide an overview of the development, clinical testing, and applications of this novel MR contrast agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Klinikum Karlsruhe, Karlsruhe, Germany;

ABSTRACT
The value of cross-sectional liver imaging is evaluated by the accuracy, sensitivity, and specificity of the specific imaging technique. Magnetic resonance imaging (MRI) has become a key technique for the characterization and detection of focal and diffuse liver disease. More recently, gadoxetic acid, the hepatocyte-specific MR contrast agent, was clinically approved and introduced in many countries. Gadoxetic acid may be considered a "molecular imaging" probe because the compound is actively taken into hepatocytes via the ATP-dependent organic anion transport system in the plasma membrane for the hepatic uptake. The transport of gadoxetic acid from the cytoplasm to the bile is mainly determined by the capacity of the transport protein glutathione-S-transferase. Gadoxetic acid enhances hepatocyte-containing lesions and improves detection of lesions devoid of normal hepatocytes, such as metastases. Innovative rapid MR acquisition techniques with near isotropic 3D pulse sequences with fat saturation parallel the technical progress made by multidetector computed tomography combined with an impressive improvement in tumor-liver contrast when used for gadoxetic acid-enhanced MRI. The purpose of this review is to provide an overview of the development, clinical testing, and applications of this novel MR contrast agent.

No MeSH data available.


Related in: MedlinePlus