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Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study.

Schuur M, Henneman P, van Swieten JC, Zillikens MC, de Koning I, Janssens AC, Witteman JC, Aulchenko YS, Frants RR, Oostra BA, van Dijk KW, van Duijn CM - Eur. J. Epidemiol. (2010)

Bottom Line: Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men).People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels.MetS and HOMA-IR are associated with poorer executive function in women.

View Article: PubMed Central - PubMed

Affiliation: Genetic Epidemiology Unit Ee2173, Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. m.schuur@erasmusmc.nl

ABSTRACT
While type 2 diabetes is well-known to be associated with poorer cognitive performance, few studies have reported on the association of metabolic syndrome (MetS) and contributing factors, such as insulin-resistance (HOMA-IR), low adiponectin-, and high C-reactive protein (CRP)-levels. We studied whether these factors are related to cognitive function and which of the MetS components are independently associated. The study was embedded in an ongoing family-based cohort study in a Dutch population. All participants underwent physical examinations, biomedical measurements, and neuropsychological testing. Linear regression models were used to determine the association between MetS, HOMA-IR, adiponectin levels, CRP, and cognitive test scores. Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men). People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels. MetS and high HOMA-IR were associated with poorer executive function in women (P = 0.03 and P = 0.009). MetS and HOMA-IR are associated with poorer executive function in women.

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Associations of HOMA-IR (a), adiponectin (b), and CRP (c) with cognitive function in men and women Results are presented as mean differences compared to quartile 1. The differences are adjusted for age, education, depressive score, alcohol use and family-relationship. HOMA-IR = homeostatis model assessment insulin-resistance, CRP = C-reactive protein * P-value < 0.05; ** P-value < 0.01
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Fig1: Associations of HOMA-IR (a), adiponectin (b), and CRP (c) with cognitive function in men and women Results are presented as mean differences compared to quartile 1. The differences are adjusted for age, education, depressive score, alcohol use and family-relationship. HOMA-IR = homeostatis model assessment insulin-resistance, CRP = C-reactive protein * P-value < 0.05; ** P-value < 0.01

Mentions: The findings related to adipose tissue endocrine function are given in Fig. 1 with analyses limited to executive function. Women with high HOMA-IR scores had lower scores on TMT, Stroop and z-executive than women with low HOMA-IR scores. Higher adiponectin levels were associated with higher scores on z-executive in both men and women and with Stroop in women only. The associations of HOMA-IR with Stroop and z-executive were more significant (P = 0.004 and 0.007) when analyzing HOMA-IR as continuous variables instead of quartiles. The other associations, however, became non-significant. No association between CRP and executive function was found in this population.Fig. 1


Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study.

Schuur M, Henneman P, van Swieten JC, Zillikens MC, de Koning I, Janssens AC, Witteman JC, Aulchenko YS, Frants RR, Oostra BA, van Dijk KW, van Duijn CM - Eur. J. Epidemiol. (2010)

Associations of HOMA-IR (a), adiponectin (b), and CRP (c) with cognitive function in men and women Results are presented as mean differences compared to quartile 1. The differences are adjusted for age, education, depressive score, alcohol use and family-relationship. HOMA-IR = homeostatis model assessment insulin-resistance, CRP = C-reactive protein * P-value < 0.05; ** P-value < 0.01
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2921069&req=5

Fig1: Associations of HOMA-IR (a), adiponectin (b), and CRP (c) with cognitive function in men and women Results are presented as mean differences compared to quartile 1. The differences are adjusted for age, education, depressive score, alcohol use and family-relationship. HOMA-IR = homeostatis model assessment insulin-resistance, CRP = C-reactive protein * P-value < 0.05; ** P-value < 0.01
Mentions: The findings related to adipose tissue endocrine function are given in Fig. 1 with analyses limited to executive function. Women with high HOMA-IR scores had lower scores on TMT, Stroop and z-executive than women with low HOMA-IR scores. Higher adiponectin levels were associated with higher scores on z-executive in both men and women and with Stroop in women only. The associations of HOMA-IR with Stroop and z-executive were more significant (P = 0.004 and 0.007) when analyzing HOMA-IR as continuous variables instead of quartiles. The other associations, however, became non-significant. No association between CRP and executive function was found in this population.Fig. 1

Bottom Line: Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men).People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels.MetS and HOMA-IR are associated with poorer executive function in women.

View Article: PubMed Central - PubMed

Affiliation: Genetic Epidemiology Unit Ee2173, Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. m.schuur@erasmusmc.nl

ABSTRACT
While type 2 diabetes is well-known to be associated with poorer cognitive performance, few studies have reported on the association of metabolic syndrome (MetS) and contributing factors, such as insulin-resistance (HOMA-IR), low adiponectin-, and high C-reactive protein (CRP)-levels. We studied whether these factors are related to cognitive function and which of the MetS components are independently associated. The study was embedded in an ongoing family-based cohort study in a Dutch population. All participants underwent physical examinations, biomedical measurements, and neuropsychological testing. Linear regression models were used to determine the association between MetS, HOMA-IR, adiponectin levels, CRP, and cognitive test scores. Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men). People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels. MetS and high HOMA-IR were associated with poorer executive function in women (P = 0.03 and P = 0.009). MetS and HOMA-IR are associated with poorer executive function in women.

Show MeSH
Related in: MedlinePlus