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Molecular imaging of angiogenesis with SPECT.

Dijkgraaf I, Boerman OC - Eur. J. Nucl. Med. Mol. Imaging (2010)

Bottom Line: Single-photon emission computed tomography (SPECT) and position emission tomography (PET) are the two main imaging modalities in nuclear medicine.Commonly used gamma emitters are: (99m)Tc (E(max) 141 keV, T (1/2) 6.02 h), (123)I (E(max) 529 keV, T (1/2) 13.0 h) and (111)In (E(max) 245 keV, T (1/2) 67.2 h).The resolution of microSPECT cameras (<0.5 mm) is higher than that of microPET cameras (>1.5 mm).

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, The Netherlands. I.Dijkgraaf@nucmed.umcn.nl

ABSTRACT
Single-photon emission computed tomography (SPECT) and position emission tomography (PET) are the two main imaging modalities in nuclear medicine. SPECT imaging is more widely available than PET imaging and the radionuclides used for SPECT are easier to prepare and usually have a longer half-life than those used for PET. In addition, SPECT is a less expensive technique than PET. Commonly used gamma emitters are: (99m)Tc (E(max) 141 keV, T (1/2) 6.02 h), (123)I (E(max) 529 keV, T (1/2) 13.0 h) and (111)In (E(max) 245 keV, T (1/2) 67.2 h). Compared to clinical SPECT, PET has a higher spatial resolution and the possibility to more accurately estimate the in vivo concentration of a tracer. In preclinical imaging, the situation is quite different. The resolution of microSPECT cameras (<0.5 mm) is higher than that of microPET cameras (>1.5 mm). In this report, studies on new radiolabelled tracers for SPECT imaging of angiogenesis in tumours are reviewed.

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a Structural formula of NC100692. b Patient with uptake of 99mTc-NC100692 in cancer in the left breast, axillary and subclavicular lymf nodes (This image was kindly provided by Dr. Rimma Axelsson, Division of Radiology, Karolinska Institutet, Stockholm, Sweden)
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Fig2: a Structural formula of NC100692. b Patient with uptake of 99mTc-NC100692 in cancer in the left breast, axillary and subclavicular lymf nodes (This image was kindly provided by Dr. Rimma Axelsson, Division of Radiology, Karolinska Institutet, Stockholm, Sweden)

Mentions: The 99mTc-labelled RGD-containing peptide (NC100692, Fig. 2) was evaluated in ischaemic models and showed high uptake in areas of neovascularization with αvβ3 integrin overexpression [55]. In these models it was shown that NC100692 bound to αvβ3-expressing endothelial cells in regions of angiogenesis [56].Fig. 2


Molecular imaging of angiogenesis with SPECT.

Dijkgraaf I, Boerman OC - Eur. J. Nucl. Med. Mol. Imaging (2010)

a Structural formula of NC100692. b Patient with uptake of 99mTc-NC100692 in cancer in the left breast, axillary and subclavicular lymf nodes (This image was kindly provided by Dr. Rimma Axelsson, Division of Radiology, Karolinska Institutet, Stockholm, Sweden)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2914864&req=5

Fig2: a Structural formula of NC100692. b Patient with uptake of 99mTc-NC100692 in cancer in the left breast, axillary and subclavicular lymf nodes (This image was kindly provided by Dr. Rimma Axelsson, Division of Radiology, Karolinska Institutet, Stockholm, Sweden)
Mentions: The 99mTc-labelled RGD-containing peptide (NC100692, Fig. 2) was evaluated in ischaemic models and showed high uptake in areas of neovascularization with αvβ3 integrin overexpression [55]. In these models it was shown that NC100692 bound to αvβ3-expressing endothelial cells in regions of angiogenesis [56].Fig. 2

Bottom Line: Single-photon emission computed tomography (SPECT) and position emission tomography (PET) are the two main imaging modalities in nuclear medicine.Commonly used gamma emitters are: (99m)Tc (E(max) 141 keV, T (1/2) 6.02 h), (123)I (E(max) 529 keV, T (1/2) 13.0 h) and (111)In (E(max) 245 keV, T (1/2) 67.2 h).The resolution of microSPECT cameras (<0.5 mm) is higher than that of microPET cameras (>1.5 mm).

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, The Netherlands. I.Dijkgraaf@nucmed.umcn.nl

ABSTRACT
Single-photon emission computed tomography (SPECT) and position emission tomography (PET) are the two main imaging modalities in nuclear medicine. SPECT imaging is more widely available than PET imaging and the radionuclides used for SPECT are easier to prepare and usually have a longer half-life than those used for PET. In addition, SPECT is a less expensive technique than PET. Commonly used gamma emitters are: (99m)Tc (E(max) 141 keV, T (1/2) 6.02 h), (123)I (E(max) 529 keV, T (1/2) 13.0 h) and (111)In (E(max) 245 keV, T (1/2) 67.2 h). Compared to clinical SPECT, PET has a higher spatial resolution and the possibility to more accurately estimate the in vivo concentration of a tracer. In preclinical imaging, the situation is quite different. The resolution of microSPECT cameras (<0.5 mm) is higher than that of microPET cameras (>1.5 mm). In this report, studies on new radiolabelled tracers for SPECT imaging of angiogenesis in tumours are reviewed.

Show MeSH
Related in: MedlinePlus