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Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice.

Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y - Nutr Metab (Lond) (2010)

Bottom Line: The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.CR dramatically prevented high-fat diet-induced metabolic abnormalities.CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Graduate School of the Chinese Academy of Sciences; Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. zhen.yan@virginia.edu.

ABSTRACT

Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.

Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression.

Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.

Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.

No MeSH data available.


Related in: MedlinePlus

Alleviation of obesity-associated dyslipidemia by restricted food intake and exercise. (A) Serum triglyceride and (B) cholesterol levels were measured in mice subjected to food restriction versus exercise for 8 weeks. Data were obtained from pooled samples from 2 mice for each group and are shown as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC, and #p < 0.05, ##p < 0.01 vs. HC; ΔΔp < 0.01 vs. HRE; N.S.: not significant.
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Figure 4: Alleviation of obesity-associated dyslipidemia by restricted food intake and exercise. (A) Serum triglyceride and (B) cholesterol levels were measured in mice subjected to food restriction versus exercise for 8 weeks. Data were obtained from pooled samples from 2 mice for each group and are shown as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC, and #p < 0.05, ##p < 0.01 vs. HC; ΔΔp < 0.01 vs. HRE; N.S.: not significant.

Mentions: High-fat diet resulted in increased levels of serum triglyceride (TG) and cholesterol, both could be corrected by CR. Endurance exercise had no significant effects in reducing serum cholesterol level, and the combined interventions did not show an additive effect (Figure 4).


Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice.

Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y - Nutr Metab (Lond) (2010)

Alleviation of obesity-associated dyslipidemia by restricted food intake and exercise. (A) Serum triglyceride and (B) cholesterol levels were measured in mice subjected to food restriction versus exercise for 8 weeks. Data were obtained from pooled samples from 2 mice for each group and are shown as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC, and #p < 0.05, ##p < 0.01 vs. HC; ΔΔp < 0.01 vs. HRE; N.S.: not significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2914080&req=5

Figure 4: Alleviation of obesity-associated dyslipidemia by restricted food intake and exercise. (A) Serum triglyceride and (B) cholesterol levels were measured in mice subjected to food restriction versus exercise for 8 weeks. Data were obtained from pooled samples from 2 mice for each group and are shown as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC, and #p < 0.05, ##p < 0.01 vs. HC; ΔΔp < 0.01 vs. HRE; N.S.: not significant.
Mentions: High-fat diet resulted in increased levels of serum triglyceride (TG) and cholesterol, both could be corrected by CR. Endurance exercise had no significant effects in reducing serum cholesterol level, and the combined interventions did not show an additive effect (Figure 4).

Bottom Line: The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.CR dramatically prevented high-fat diet-induced metabolic abnormalities.CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Graduate School of the Chinese Academy of Sciences; Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. zhen.yan@virginia.edu.

ABSTRACT

Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.

Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression.

Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.

Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.

No MeSH data available.


Related in: MedlinePlus