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Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice.

Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y - Nutr Metab (Lond) (2010)

Bottom Line: The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.CR dramatically prevented high-fat diet-induced metabolic abnormalities.CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Graduate School of the Chinese Academy of Sciences; Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. zhen.yan@virginia.edu.

ABSTRACT

Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.

Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression.

Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.

Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.

No MeSH data available.


Related in: MedlinePlus

Metabolic effects of caloric restriction versus voluntary exercise on high-fat diet-induced obesity. (A) Body weight and (B) total body fat mass as percentage of body weight were determined after 8 weeks of intervention. Data are presented as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC; #p < 0.05, ##p < 0.01 vs. HC; Δp < 0.05, ΔΔp < 0.01 vs. HRE.
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Figure 2: Metabolic effects of caloric restriction versus voluntary exercise on high-fat diet-induced obesity. (A) Body weight and (B) total body fat mass as percentage of body weight were determined after 8 weeks of intervention. Data are presented as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC; #p < 0.05, ##p < 0.01 vs. HC; Δp < 0.05, ΔΔp < 0.01 vs. HRE.

Mentions: To directly compare the impacts of CR and exercise on diet-induced obesity, we subjected mice to endurance exercise and/or CR interventions. CR did not affect the running distance of mice on the high-fat diet (Figure 1A). Exercise did not cause a significant change in caloric intake in mice on high-fat diet (HE vs. HC, Figure 1B). Mice with CR on the high-fat diet had 15% less caloric intake than mice on the low-fat diet (HR vs. LC, Figure 1B). High-fat diet significantly increased body weight and percent body fat, and CR and endurance exercise resulted in significant reductions in body weight and percent body fat. A combination of endurance exercise and CR resulted in further reductions in these parameters (Figure 2).


Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice.

Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y - Nutr Metab (Lond) (2010)

Metabolic effects of caloric restriction versus voluntary exercise on high-fat diet-induced obesity. (A) Body weight and (B) total body fat mass as percentage of body weight were determined after 8 weeks of intervention. Data are presented as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC; #p < 0.05, ##p < 0.01 vs. HC; Δp < 0.05, ΔΔp < 0.01 vs. HRE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2914080&req=5

Figure 2: Metabolic effects of caloric restriction versus voluntary exercise on high-fat diet-induced obesity. (A) Body weight and (B) total body fat mass as percentage of body weight were determined after 8 weeks of intervention. Data are presented as means ± SEM (n = 6/group). Statistical analyses were done with one-way ANOVA. *p < 0.05, **p < 0.01 vs. LC; #p < 0.05, ##p < 0.01 vs. HC; Δp < 0.05, ΔΔp < 0.01 vs. HRE.
Mentions: To directly compare the impacts of CR and exercise on diet-induced obesity, we subjected mice to endurance exercise and/or CR interventions. CR did not affect the running distance of mice on the high-fat diet (Figure 1A). Exercise did not cause a significant change in caloric intake in mice on high-fat diet (HE vs. HC, Figure 1B). Mice with CR on the high-fat diet had 15% less caloric intake than mice on the low-fat diet (HR vs. LC, Figure 1B). High-fat diet significantly increased body weight and percent body fat, and CR and endurance exercise resulted in significant reductions in body weight and percent body fat. A combination of endurance exercise and CR resulted in further reductions in these parameters (Figure 2).

Bottom Line: The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.CR dramatically prevented high-fat diet-induced metabolic abnormalities.CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences; Graduate School of the Chinese Academy of Sciences; Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China. zhen.yan@virginia.edu.

ABSTRACT

Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance.

Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression.

Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal.

Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.

No MeSH data available.


Related in: MedlinePlus