Limits...
Uterine primitive neuroectodermal tumor with adenosarcoma: a case report.

Bhardwaj M, Batrani M, Chawla I, Malik R - J Med Case Rep (2010)

Bottom Line: Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes.A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative.Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Dr, Ram Manohar Lohia Hospital, New Delhi, India. meenakshibatrani@yahoo.co.in.

ABSTRACT

Introduction: Primitive neuroectodermal tumor of the uterus is extremely rare. They occur as either pure primitive neuroectodermal tumors or admixed with neoplasms of mullerian origin.

Case presentation: A case of uterine primitive neuroectodermal tumor with adenosarcoma in a 50-year-old Asian Indian woman is presented. Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes. A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative. Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.

Conclusion: To the best of our knowledge, this report represents the second case of a uterine primitive neuroectodermal tumor with an admixed adenosarcoma.

No MeSH data available.


Related in: MedlinePlus

Immunostains showing (A) neuronspecific enolase positivity and (B) synaptophysin positivity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2913979&req=5

Figure 3: Immunostains showing (A) neuronspecific enolase positivity and (B) synaptophysin positivity.

Mentions: On immunohistochemistry (IHC), both spindle cell component of the adenosarcoma and small cell component were positive for vimentin. The small cell component also showed strong positivity for neuronspecific enolase (NSE), and synaptophysin (Figure 3). Chromogranin and cytokeratin examination results were negative. CD99 was also negative. A final diagnosis of stage IIIC PNET with adenosarcoma of the uterus was finally made.


Uterine primitive neuroectodermal tumor with adenosarcoma: a case report.

Bhardwaj M, Batrani M, Chawla I, Malik R - J Med Case Rep (2010)

Immunostains showing (A) neuronspecific enolase positivity and (B) synaptophysin positivity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2913979&req=5

Figure 3: Immunostains showing (A) neuronspecific enolase positivity and (B) synaptophysin positivity.
Mentions: On immunohistochemistry (IHC), both spindle cell component of the adenosarcoma and small cell component were positive for vimentin. The small cell component also showed strong positivity for neuronspecific enolase (NSE), and synaptophysin (Figure 3). Chromogranin and cytokeratin examination results were negative. CD99 was also negative. A final diagnosis of stage IIIC PNET with adenosarcoma of the uterus was finally made.

Bottom Line: Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes.A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative.Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Dr, Ram Manohar Lohia Hospital, New Delhi, India. meenakshibatrani@yahoo.co.in.

ABSTRACT

Introduction: Primitive neuroectodermal tumor of the uterus is extremely rare. They occur as either pure primitive neuroectodermal tumors or admixed with neoplasms of mullerian origin.

Case presentation: A case of uterine primitive neuroectodermal tumor with adenosarcoma in a 50-year-old Asian Indian woman is presented. Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes. A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative. Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.

Conclusion: To the best of our knowledge, this report represents the second case of a uterine primitive neuroectodermal tumor with an admixed adenosarcoma.

No MeSH data available.


Related in: MedlinePlus