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Uterine primitive neuroectodermal tumor with adenosarcoma: a case report.

Bhardwaj M, Batrani M, Chawla I, Malik R - J Med Case Rep (2010)

Bottom Line: Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes.A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative.Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Dr, Ram Manohar Lohia Hospital, New Delhi, India. meenakshibatrani@yahoo.co.in.

ABSTRACT

Introduction: Primitive neuroectodermal tumor of the uterus is extremely rare. They occur as either pure primitive neuroectodermal tumors or admixed with neoplasms of mullerian origin.

Case presentation: A case of uterine primitive neuroectodermal tumor with adenosarcoma in a 50-year-old Asian Indian woman is presented. Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes. A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative. Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.

Conclusion: To the best of our knowledge, this report represents the second case of a uterine primitive neuroectodermal tumor with an admixed adenosarcoma.

No MeSH data available.


Related in: MedlinePlus

Adenosarcoma composed of (A) glands with polypoidal stromal projections into the lumen (hematoxylin and eosin staining, ×40), (B) cleft-like epithelial lined spaces with sarcomatous stroma (hematoxylin and eosin staining, ×40), and (C) endometrial glands surrounded by sarcomatous stroma (hematoxylin and eosin staining, ×40).
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Figure 2: Adenosarcoma composed of (A) glands with polypoidal stromal projections into the lumen (hematoxylin and eosin staining, ×40), (B) cleft-like epithelial lined spaces with sarcomatous stroma (hematoxylin and eosin staining, ×40), and (C) endometrial glands surrounded by sarcomatous stroma (hematoxylin and eosin staining, ×40).

Mentions: Histology revealed a tumor with majority of the areas displaying primitive neuroectodermal differentiation and a minor component of adenosarcoma constituting around 20% of the tumor volume. The former was composed of sheets of undifferentiated, small round to oval cells with hyperchromatic nuclei and numerous mitotic figures. Micronodular pale islands with fibrillary matrix, perivascular pseudorosettes and occasional Homer-Wright rosettes were seen (Figure 1). Areas of adenosarcoma comprised of epithelial lined cleft-like spaces and glands showing mild atypia and occasional mitosis along with sarcomatous stroma and polypoidal stromal projections into the lumen (Figure 2). These glandular structures were present well away from the residual endometrium and were not accompanied by the normal endometrial stroma. Lymphovascular emboli were also seen. The tumor showed full thickness myometrial invasion and extension into the cervix. Left parametrium also showed tumor infiltration and one left external iliac lymph node showed metastasis.


Uterine primitive neuroectodermal tumor with adenosarcoma: a case report.

Bhardwaj M, Batrani M, Chawla I, Malik R - J Med Case Rep (2010)

Adenosarcoma composed of (A) glands with polypoidal stromal projections into the lumen (hematoxylin and eosin staining, ×40), (B) cleft-like epithelial lined spaces with sarcomatous stroma (hematoxylin and eosin staining, ×40), and (C) endometrial glands surrounded by sarcomatous stroma (hematoxylin and eosin staining, ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2913979&req=5

Figure 2: Adenosarcoma composed of (A) glands with polypoidal stromal projections into the lumen (hematoxylin and eosin staining, ×40), (B) cleft-like epithelial lined spaces with sarcomatous stroma (hematoxylin and eosin staining, ×40), and (C) endometrial glands surrounded by sarcomatous stroma (hematoxylin and eosin staining, ×40).
Mentions: Histology revealed a tumor with majority of the areas displaying primitive neuroectodermal differentiation and a minor component of adenosarcoma constituting around 20% of the tumor volume. The former was composed of sheets of undifferentiated, small round to oval cells with hyperchromatic nuclei and numerous mitotic figures. Micronodular pale islands with fibrillary matrix, perivascular pseudorosettes and occasional Homer-Wright rosettes were seen (Figure 1). Areas of adenosarcoma comprised of epithelial lined cleft-like spaces and glands showing mild atypia and occasional mitosis along with sarcomatous stroma and polypoidal stromal projections into the lumen (Figure 2). These glandular structures were present well away from the residual endometrium and were not accompanied by the normal endometrial stroma. Lymphovascular emboli were also seen. The tumor showed full thickness myometrial invasion and extension into the cervix. Left parametrium also showed tumor infiltration and one left external iliac lymph node showed metastasis.

Bottom Line: Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes.A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative.Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Dr, Ram Manohar Lohia Hospital, New Delhi, India. meenakshibatrani@yahoo.co.in.

ABSTRACT

Introduction: Primitive neuroectodermal tumor of the uterus is extremely rare. They occur as either pure primitive neuroectodermal tumors or admixed with neoplasms of mullerian origin.

Case presentation: A case of uterine primitive neuroectodermal tumor with adenosarcoma in a 50-year-old Asian Indian woman is presented. Histologically, the neoplasm displayed perivascular pseudorosettes and occasional Homer-Wright rosettes. A strong positivity for neuronspecific enolase and synaptophysin was noted, while chromogranin and CD99 were negative. Merging imperceptibly with the neuroectodermal components were the areas of adenosarcoma.

Conclusion: To the best of our knowledge, this report represents the second case of a uterine primitive neuroectodermal tumor with an admixed adenosarcoma.

No MeSH data available.


Related in: MedlinePlus