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Chronic consumption of fructose rich soft drinks alters tissue lipids of rats.

Botezelli JD, Dalia RA, Reis IM, Barbieri RA, Rezende TM, Pelarigo JG, Codogno J, Gonçalves R, Mello MA - Diabetol Metab Syndr (2010)

Bottom Line: Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described.The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups.Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.

View Article: PubMed Central - HTML - PubMed

Affiliation: São Paulo State University - UNESP, Department of Physical Education, Av: 24-A, 1515 Bela Vista, Zip code: 13506-900, Rio Claro - São Paulo- Brazil. jdbotezelli@yahoo.com.br.

ABSTRACT

Background: Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described. The aim of this study was to analyze the general characteristics and the lipid content of different tissues of rats after chronic ingestion of a fructose rich soft drink.

Methods: Forty-five Wistar rats were used. The rats were divided into three groups (n = 15) and allowed to consume water (C), light Coca Cola (R) (L) or regular Coca Cola(R) (R) as the sole source of liquids for eight weeks.

Results: The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups. Moreover, relative to the C and L groups, the R group showed higher triglyceride concentrations in the serum and liver. However, the L group animals presented lower values of serum triglycerides and cholesterol than controls.

Conclusions: Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.

No MeSH data available.


Liver and soleus triglycerides. Liver and soleus muscle triglycerides of the rats at the end of the experiment. C = Control; L = Light Soft Drink; R = Soft Drink. n = 8 animals in each group. * ≠ C. ‡ ≠ L.
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Figure 4: Liver and soleus triglycerides. Liver and soleus muscle triglycerides of the rats at the end of the experiment. C = Control; L = Light Soft Drink; R = Soft Drink. n = 8 animals in each group. * ≠ C. ‡ ≠ L.

Mentions: In Figure 4, it can be observed that the R group presented significantly higher liver triglycerides than the C and L groups.


Chronic consumption of fructose rich soft drinks alters tissue lipids of rats.

Botezelli JD, Dalia RA, Reis IM, Barbieri RA, Rezende TM, Pelarigo JG, Codogno J, Gonçalves R, Mello MA - Diabetol Metab Syndr (2010)

Liver and soleus triglycerides. Liver and soleus muscle triglycerides of the rats at the end of the experiment. C = Control; L = Light Soft Drink; R = Soft Drink. n = 8 animals in each group. * ≠ C. ‡ ≠ L.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2913938&req=5

Figure 4: Liver and soleus triglycerides. Liver and soleus muscle triglycerides of the rats at the end of the experiment. C = Control; L = Light Soft Drink; R = Soft Drink. n = 8 animals in each group. * ≠ C. ‡ ≠ L.
Mentions: In Figure 4, it can be observed that the R group presented significantly higher liver triglycerides than the C and L groups.

Bottom Line: Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described.The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups.Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.

View Article: PubMed Central - HTML - PubMed

Affiliation: São Paulo State University - UNESP, Department of Physical Education, Av: 24-A, 1515 Bela Vista, Zip code: 13506-900, Rio Claro - São Paulo- Brazil. jdbotezelli@yahoo.com.br.

ABSTRACT

Background: Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described. The aim of this study was to analyze the general characteristics and the lipid content of different tissues of rats after chronic ingestion of a fructose rich soft drink.

Methods: Forty-five Wistar rats were used. The rats were divided into three groups (n = 15) and allowed to consume water (C), light Coca Cola (R) (L) or regular Coca Cola(R) (R) as the sole source of liquids for eight weeks.

Results: The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups. Moreover, relative to the C and L groups, the R group showed higher triglyceride concentrations in the serum and liver. However, the L group animals presented lower values of serum triglycerides and cholesterol than controls.

Conclusions: Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.

No MeSH data available.