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Chronic consumption of fructose rich soft drinks alters tissue lipids of rats.

Botezelli JD, Dalia RA, Reis IM, Barbieri RA, Rezende TM, Pelarigo JG, Codogno J, Gonçalves R, Mello MA - Diabetol Metab Syndr (2010)

Bottom Line: Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described.The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups.Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.

View Article: PubMed Central - HTML - PubMed

Affiliation: São Paulo State University - UNESP, Department of Physical Education, Av: 24-A, 1515 Bela Vista, Zip code: 13506-900, Rio Claro - São Paulo- Brazil. jdbotezelli@yahoo.com.br.

ABSTRACT

Background: Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described. The aim of this study was to analyze the general characteristics and the lipid content of different tissues of rats after chronic ingestion of a fructose rich soft drink.

Methods: Forty-five Wistar rats were used. The rats were divided into three groups (n = 15) and allowed to consume water (C), light Coca Cola (R) (L) or regular Coca Cola(R) (R) as the sole source of liquids for eight weeks.

Results: The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups. Moreover, relative to the C and L groups, the R group showed higher triglyceride concentrations in the serum and liver. However, the L group animals presented lower values of serum triglycerides and cholesterol than controls.

Conclusions: Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.

No MeSH data available.


Change in body weight. Evolution of body weight and weight gain of rats during the experiment. Body weight was measured and registered once a week. C = Control; L = Light Soft Drink; R = Regular Soft Drink. n= 15 animals per group. * ≠ C. ‡ ≠ L
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Figure 2: Change in body weight. Evolution of body weight and weight gain of rats during the experiment. Body weight was measured and registered once a week. C = Control; L = Light Soft Drink; R = Regular Soft Drink. n= 15 animals per group. * ≠ C. ‡ ≠ L

Mentions: As shown in Figure 1, the R group animals presented a mean daily food intake that was significantly lower and a mean liquid intake that was significantly higher than those of the animals in the C and L groups. There was no significant difference in the evolution of body weight among the three groups of animals during the experiment (Figure 2).


Chronic consumption of fructose rich soft drinks alters tissue lipids of rats.

Botezelli JD, Dalia RA, Reis IM, Barbieri RA, Rezende TM, Pelarigo JG, Codogno J, Gonçalves R, Mello MA - Diabetol Metab Syndr (2010)

Change in body weight. Evolution of body weight and weight gain of rats during the experiment. Body weight was measured and registered once a week. C = Control; L = Light Soft Drink; R = Regular Soft Drink. n= 15 animals per group. * ≠ C. ‡ ≠ L
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2913938&req=5

Figure 2: Change in body weight. Evolution of body weight and weight gain of rats during the experiment. Body weight was measured and registered once a week. C = Control; L = Light Soft Drink; R = Regular Soft Drink. n= 15 animals per group. * ≠ C. ‡ ≠ L
Mentions: As shown in Figure 1, the R group animals presented a mean daily food intake that was significantly lower and a mean liquid intake that was significantly higher than those of the animals in the C and L groups. There was no significant difference in the evolution of body weight among the three groups of animals during the experiment (Figure 2).

Bottom Line: Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described.The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups.Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.

View Article: PubMed Central - HTML - PubMed

Affiliation: São Paulo State University - UNESP, Department of Physical Education, Av: 24-A, 1515 Bela Vista, Zip code: 13506-900, Rio Claro - São Paulo- Brazil. jdbotezelli@yahoo.com.br.

ABSTRACT

Background: Fructose-based diets are apparently related to the occurrence of several metabolic dysfunctions, but the effects of the consumption of high amounts of fructose on body tissues have not been well described. The aim of this study was to analyze the general characteristics and the lipid content of different tissues of rats after chronic ingestion of a fructose rich soft drink.

Methods: Forty-five Wistar rats were used. The rats were divided into three groups (n = 15) and allowed to consume water (C), light Coca Cola (R) (L) or regular Coca Cola(R) (R) as the sole source of liquids for eight weeks.

Results: The R group presented significantly higher daily liquid intake and significantly lower food intake than the C and L groups. Moreover, relative to the C and L groups, the R group showed higher triglyceride concentrations in the serum and liver. However, the L group animals presented lower values of serum triglycerides and cholesterol than controls.

Conclusions: Based on the results, it can be concluded that daily ingestion of a large amount of fructose- rich soft drink resulted in unfavorable alterations to the lipid profile of the rats.

No MeSH data available.