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Regulatory effect of melatonin on cytokine disturbances in the pristane-induced lupus mice.

Zhou LL, Wei W, Si JF, Yuan DP - Mediators Inflamm. (2010)

Bottom Line: The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies.Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production.These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Anti-inflammatory and immunopharmacology in Education Ministry of China, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China.

ABSTRACT
Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.

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Related in: MedlinePlus

The kidneys collected at the time of sacrifice were stained with H&E for histological examination. (a) Normal control group (HE × 200). (b) Model control group (HE × 200). (c) Model control group (HE × 400). (d) MT group (HE × 200).
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fig3: The kidneys collected at the time of sacrifice were stained with H&E for histological examination. (a) Normal control group (HE × 200). (b) Model control group (HE × 200). (c) Model control group (HE × 400). (d) MT group (HE × 200).

Mentions: The renal histopathological changes of the mice are shown in Table 1 and Figure 3.


Regulatory effect of melatonin on cytokine disturbances in the pristane-induced lupus mice.

Zhou LL, Wei W, Si JF, Yuan DP - Mediators Inflamm. (2010)

The kidneys collected at the time of sacrifice were stained with H&E for histological examination. (a) Normal control group (HE × 200). (b) Model control group (HE × 200). (c) Model control group (HE × 400). (d) MT group (HE × 200).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2913856&req=5

fig3: The kidneys collected at the time of sacrifice were stained with H&E for histological examination. (a) Normal control group (HE × 200). (b) Model control group (HE × 200). (c) Model control group (HE × 400). (d) MT group (HE × 200).
Mentions: The renal histopathological changes of the mice are shown in Table 1 and Figure 3.

Bottom Line: The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies.Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production.These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Anti-inflammatory and immunopharmacology in Education Ministry of China, Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China.

ABSTRACT
Systemic lupus erythematosus (SLE) develops in relation to many environmental factors. In our opinion, it is more important to investigate the effect of melatonin on the environmental- related SLE. In the present study, 0.5 ml pristane were used to induce SLE in female BALB/c mice. Melatonin (0.01, 0.1, 1.0 mg/kg) was orally administered immediately after pristane-injection for 24 weeks. IgM anti ssDNA and histone antibodies were detected after 0, 1, 2, 4, 8 weeks pristane injection. The levels of IL-2, IL-6 and IL-13 were detected after 24 weeks. Renal lesions were also observed. The results showed that melatonin antagonized the increasing levels of IgM anti ssDNA and histone autoantibodies. Melatonin could also decrease the IL-6 and IL-13 production and increase the IL-2 production. Besides, melatonin could lessen the renal lesions caused by pristane. These results suggested that melatonin has a beneficial effect on pristane-induced lupus through regulating the cytokines disturbances.

Show MeSH
Related in: MedlinePlus