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High-Speed Burring with and without the Use of Surgical Adjuvants in the Intralesional Management of Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis.

Algawahmed H, Turcotte R, Farrokhyar F, Ghert M - Sarcoma (2010)

Bottom Line: Studies were evaluated for quality and pooled data was analyzed using the fixed effects model.Data from 387 patients did not indicate improved local control with the use of surgical adjuvants.Given the available data, we conclude that surgical adjuvants are not required when meticulous tumor removal is performed.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada L8V 5C2.

ABSTRACT
Local control rates for Giant Cell Tumor of Bone (GCT) have been reported in a large number of retrospective series. However, there remains a lack of consensus with respect to the need for a surgical adjuvant when intralesional curettage is performed. We have systematically reviewed the literature and identified six studies in which two groups from the same patient cohort were treated with intralesional curettage and high-speed burring with or without a chemical or thermal adjuvant. Studies were evaluated for quality and pooled data was analyzed using the fixed effects model. Data from 387 patients did not indicate improved local control with the use of surgical adjuvants. Given the available data, we conclude that surgical adjuvants are not required when meticulous tumor removal is performed.

No MeSH data available.


Related in: MedlinePlus

Literature search flow diagram.
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fig1: Literature search flow diagram.

Mentions: Our initial search through the electronic databases yielded 2557 titles. After manual review of titles and abstracts, 2544 articles were excluded and 13 articles were determined relevant. Full text review was performed and five studies were excluded as they did not meet the inclusion criteria (appropriate comparison groups not present within the patient cohort). Two further studies were excluded following corresponding author contact due to unavailable original patient data regarding the use of a high-speed burr [11, 14]. Therefore, six studies were found to meet the criteria and were included in this meta-analysis (Figure 1) [2, 3, 9, 12, 22, 24].


High-Speed Burring with and without the Use of Surgical Adjuvants in the Intralesional Management of Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis.

Algawahmed H, Turcotte R, Farrokhyar F, Ghert M - Sarcoma (2010)

Literature search flow diagram.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2913811&req=5

fig1: Literature search flow diagram.
Mentions: Our initial search through the electronic databases yielded 2557 titles. After manual review of titles and abstracts, 2544 articles were excluded and 13 articles were determined relevant. Full text review was performed and five studies were excluded as they did not meet the inclusion criteria (appropriate comparison groups not present within the patient cohort). Two further studies were excluded following corresponding author contact due to unavailable original patient data regarding the use of a high-speed burr [11, 14]. Therefore, six studies were found to meet the criteria and were included in this meta-analysis (Figure 1) [2, 3, 9, 12, 22, 24].

Bottom Line: Studies were evaluated for quality and pooled data was analyzed using the fixed effects model.Data from 387 patients did not indicate improved local control with the use of surgical adjuvants.Given the available data, we conclude that surgical adjuvants are not required when meticulous tumor removal is performed.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada L8V 5C2.

ABSTRACT
Local control rates for Giant Cell Tumor of Bone (GCT) have been reported in a large number of retrospective series. However, there remains a lack of consensus with respect to the need for a surgical adjuvant when intralesional curettage is performed. We have systematically reviewed the literature and identified six studies in which two groups from the same patient cohort were treated with intralesional curettage and high-speed burring with or without a chemical or thermal adjuvant. Studies were evaluated for quality and pooled data was analyzed using the fixed effects model. Data from 387 patients did not indicate improved local control with the use of surgical adjuvants. Given the available data, we conclude that surgical adjuvants are not required when meticulous tumor removal is performed.

No MeSH data available.


Related in: MedlinePlus