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Late simultaneous metastasis of renal cell carcinoma to the submandibular and thyroid glands seven years after radical nephrectomy.

Miah MS, White SJ, Oommen G, Birney E, Majumdar S - Int J Otolaryngol (2010)

Bottom Line: We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment.The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology-Head & Neck Surgery, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK.

ABSTRACT
Background. Renal cell carcinoma (RCC) metastasis to the salivary glands is extremely rare. Most cases reported previously have involved the parotid gland and only six cases involving the submandibular gland exist in the current literature. Metastasis of RCC to thyroid gland is also rare but appears to be more common than to salivary glands. Methods and Results. We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment. The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively. Conclusion. Metastatic disease should always be considered in the differential diagnosis for patients who present with painless salivary or thyroid gland swelling with a previous history of RCC. If metastatic disease is confined only to these glands, prompt surgical excision can be curative.

No MeSH data available.


Related in: MedlinePlus

Macroscopic specimens showing metastatic RCC within the submandibular (a) and thyroid (b) glands. Solid metastatic tumours can be seen to be surrounded by normal glandular tissue in both cases without any extraglandular extension.
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fig3: Macroscopic specimens showing metastatic RCC within the submandibular (a) and thyroid (b) glands. Solid metastatic tumours can be seen to be surrounded by normal glandular tissue in both cases without any extraglandular extension.

Mentions: Metastasis of RCC to the major salivary glands is extremely rare. Our search only found a handful of reported cases with a predominance of parotid gland metastases. Based on our search, only six cases of RCC metastasis to the submandibular gland exist in the current literature (one of the six reports describes RCC metastasis to Wharton's duct) [10]. Our case is unique with simultaneous solitary metastases within the submandibular and thyroid glands, surrounded by normal glandular tissue, with no evidence of extraglandular extension (Figure 3). We cannot speculate a pathogenetic mechanism to explain this phenomenon at this stage.


Late simultaneous metastasis of renal cell carcinoma to the submandibular and thyroid glands seven years after radical nephrectomy.

Miah MS, White SJ, Oommen G, Birney E, Majumdar S - Int J Otolaryngol (2010)

Macroscopic specimens showing metastatic RCC within the submandibular (a) and thyroid (b) glands. Solid metastatic tumours can be seen to be surrounded by normal glandular tissue in both cases without any extraglandular extension.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2913808&req=5

fig3: Macroscopic specimens showing metastatic RCC within the submandibular (a) and thyroid (b) glands. Solid metastatic tumours can be seen to be surrounded by normal glandular tissue in both cases without any extraglandular extension.
Mentions: Metastasis of RCC to the major salivary glands is extremely rare. Our search only found a handful of reported cases with a predominance of parotid gland metastases. Based on our search, only six cases of RCC metastasis to the submandibular gland exist in the current literature (one of the six reports describes RCC metastasis to Wharton's duct) [10]. Our case is unique with simultaneous solitary metastases within the submandibular and thyroid glands, surrounded by normal glandular tissue, with no evidence of extraglandular extension (Figure 3). We cannot speculate a pathogenetic mechanism to explain this phenomenon at this stage.

Bottom Line: We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment.The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology-Head & Neck Surgery, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK.

ABSTRACT
Background. Renal cell carcinoma (RCC) metastasis to the salivary glands is extremely rare. Most cases reported previously have involved the parotid gland and only six cases involving the submandibular gland exist in the current literature. Metastasis of RCC to thyroid gland is also rare but appears to be more common than to salivary glands. Methods and Results. We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment. The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively. Conclusion. Metastatic disease should always be considered in the differential diagnosis for patients who present with painless salivary or thyroid gland swelling with a previous history of RCC. If metastatic disease is confined only to these glands, prompt surgical excision can be curative.

No MeSH data available.


Related in: MedlinePlus