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Late simultaneous metastasis of renal cell carcinoma to the submandibular and thyroid glands seven years after radical nephrectomy.

Miah MS, White SJ, Oommen G, Birney E, Majumdar S - Int J Otolaryngol (2010)

Bottom Line: We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment.The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology-Head & Neck Surgery, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK.

ABSTRACT
Background. Renal cell carcinoma (RCC) metastasis to the salivary glands is extremely rare. Most cases reported previously have involved the parotid gland and only six cases involving the submandibular gland exist in the current literature. Metastasis of RCC to thyroid gland is also rare but appears to be more common than to salivary glands. Methods and Results. We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment. The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively. Conclusion. Metastatic disease should always be considered in the differential diagnosis for patients who present with painless salivary or thyroid gland swelling with a previous history of RCC. If metastatic disease is confined only to these glands, prompt surgical excision can be curative.

No MeSH data available.


Related in: MedlinePlus

CT of neck with contrast. (a) Well-defined tumour mass in the right submandibular gland measuring 29 × 26 × 30 mm. It shows prominent vascularisation which would be unusual for benign lesion such as PA. There is some low-density area centrally in the tumour probably related to necrosis. (b) There is a large nodule in the thyroid on the right side measuring 26 × 23 × 30 mm showing similar intense enhancement as the submandibular lesion.
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fig1: CT of neck with contrast. (a) Well-defined tumour mass in the right submandibular gland measuring 29 × 26 × 30 mm. It shows prominent vascularisation which would be unusual for benign lesion such as PA. There is some low-density area centrally in the tumour probably related to necrosis. (b) There is a large nodule in the thyroid on the right side measuring 26 × 23 × 30 mm showing similar intense enhancement as the submandibular lesion.

Mentions: She was then seen in our otolaryngology department where a complete ear, nose, and throat examination was normal except for the obvious right submandibular and thyroid gland swellings. A computed tomography (CT) scan of her neck was performed which revealed a tumour mass in the right submandibular gland with prominent vascularisation unusual for benign lesions such as a PA (Figure 1). CT scan also showed a large nodule in the right thyroid with similar intense vascular enhancement as the submandibular lesion (Figure 1). There was no suspicious cervical lymphadenopathy. A bone scan showed no osseous metastases and chest X-ray revealed no pulmonary metastases.


Late simultaneous metastasis of renal cell carcinoma to the submandibular and thyroid glands seven years after radical nephrectomy.

Miah MS, White SJ, Oommen G, Birney E, Majumdar S - Int J Otolaryngol (2010)

CT of neck with contrast. (a) Well-defined tumour mass in the right submandibular gland measuring 29 × 26 × 30 mm. It shows prominent vascularisation which would be unusual for benign lesion such as PA. There is some low-density area centrally in the tumour probably related to necrosis. (b) There is a large nodule in the thyroid on the right side measuring 26 × 23 × 30 mm showing similar intense enhancement as the submandibular lesion.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2913808&req=5

fig1: CT of neck with contrast. (a) Well-defined tumour mass in the right submandibular gland measuring 29 × 26 × 30 mm. It shows prominent vascularisation which would be unusual for benign lesion such as PA. There is some low-density area centrally in the tumour probably related to necrosis. (b) There is a large nodule in the thyroid on the right side measuring 26 × 23 × 30 mm showing similar intense enhancement as the submandibular lesion.
Mentions: She was then seen in our otolaryngology department where a complete ear, nose, and throat examination was normal except for the obvious right submandibular and thyroid gland swellings. A computed tomography (CT) scan of her neck was performed which revealed a tumour mass in the right submandibular gland with prominent vascularisation unusual for benign lesions such as a PA (Figure 1). CT scan also showed a large nodule in the right thyroid with similar intense vascular enhancement as the submandibular lesion (Figure 1). There was no suspicious cervical lymphadenopathy. A bone scan showed no osseous metastases and chest X-ray revealed no pulmonary metastases.

Bottom Line: We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment.The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology-Head & Neck Surgery, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK.

ABSTRACT
Background. Renal cell carcinoma (RCC) metastasis to the salivary glands is extremely rare. Most cases reported previously have involved the parotid gland and only six cases involving the submandibular gland exist in the current literature. Metastasis of RCC to thyroid gland is also rare but appears to be more common than to salivary glands. Methods and Results. We present the first case of simultaneous metastasis to the submandibular and thyroid glands from clear cell RCC in a 61-year-old woman who presented seven years after the primary treatment. The submandibular and thyroid glands were excised completely with preservation of the marginal mandibular and recurrent laryngeal nerves, respectively. Conclusion. Metastatic disease should always be considered in the differential diagnosis for patients who present with painless salivary or thyroid gland swelling with a previous history of RCC. If metastatic disease is confined only to these glands, prompt surgical excision can be curative.

No MeSH data available.


Related in: MedlinePlus