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6-hydroxydopamine-mediated release of norepinephrine increases faecal excretion of Salmonella enterica serovar Typhimurium in pigs.

Pullinger GD, van Diemen PM, Carnell SC, Davies H, Lyte M, Stevens MP - Vet. Res. (2010)

Bottom Line: The stress-related catecholamine norepinephrine (NE) has been reported to activate growth and virulence factor expression in Salmonella; however the extent to which NE contributes to stress-associated salmonellosis is unclear.Salmonella has been proposed to sense and respond to NE via a homologue of the adrenergic sensor kinase QseC.Our data support the notion that stress-related catecholamines modulate the interaction of enteric bacterial pathogens with their hosts.

View Article: PubMed Central - PubMed

Affiliation: Enteric Bacterial Pathogens Laboratory, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom.

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The putative adrenergic sensor kinase QseC does not significantly influence intestinal colonisation of pigs. 6-week-old pigs were inoculated with 1.50 × 109 CFU ST4/74 nalR (n = 5) or 1.53 × 109 CFU ST4/74 nalR ΔqseC (n = 6) and the course of faecal excretion of the bacteria followed daily for 16 days. Values shown are the least square means (LSM) ± standard error (SE) of the LSM. † denotes p values ≤ 0.1.
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Figure 3: The putative adrenergic sensor kinase QseC does not significantly influence intestinal colonisation of pigs. 6-week-old pigs were inoculated with 1.50 × 109 CFU ST4/74 nalR (n = 5) or 1.53 × 109 CFU ST4/74 nalR ΔqseC (n = 6) and the course of faecal excretion of the bacteria followed daily for 16 days. Values shown are the least square means (LSM) ± standard error (SE) of the LSM. † denotes p values ≤ 0.1.


6-hydroxydopamine-mediated release of norepinephrine increases faecal excretion of Salmonella enterica serovar Typhimurium in pigs.

Pullinger GD, van Diemen PM, Carnell SC, Davies H, Lyte M, Stevens MP - Vet. Res. (2010)

The putative adrenergic sensor kinase QseC does not significantly influence intestinal colonisation of pigs. 6-week-old pigs were inoculated with 1.50 × 109 CFU ST4/74 nalR (n = 5) or 1.53 × 109 CFU ST4/74 nalR ΔqseC (n = 6) and the course of faecal excretion of the bacteria followed daily for 16 days. Values shown are the least square means (LSM) ± standard error (SE) of the LSM. † denotes p values ≤ 0.1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2913729&req=5

Figure 3: The putative adrenergic sensor kinase QseC does not significantly influence intestinal colonisation of pigs. 6-week-old pigs were inoculated with 1.50 × 109 CFU ST4/74 nalR (n = 5) or 1.53 × 109 CFU ST4/74 nalR ΔqseC (n = 6) and the course of faecal excretion of the bacteria followed daily for 16 days. Values shown are the least square means (LSM) ± standard error (SE) of the LSM. † denotes p values ≤ 0.1.
Bottom Line: The stress-related catecholamine norepinephrine (NE) has been reported to activate growth and virulence factor expression in Salmonella; however the extent to which NE contributes to stress-associated salmonellosis is unclear.Salmonella has been proposed to sense and respond to NE via a homologue of the adrenergic sensor kinase QseC.Our data support the notion that stress-related catecholamines modulate the interaction of enteric bacterial pathogens with their hosts.

View Article: PubMed Central - PubMed

Affiliation: Enteric Bacterial Pathogens Laboratory, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom.

Show MeSH
Related in: MedlinePlus