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6-hydroxydopamine-mediated release of norepinephrine increases faecal excretion of Salmonella enterica serovar Typhimurium in pigs.

Pullinger GD, van Diemen PM, Carnell SC, Davies H, Lyte M, Stevens MP - Vet. Res. (2010)

Bottom Line: The stress-related catecholamine norepinephrine (NE) has been reported to activate growth and virulence factor expression in Salmonella; however the extent to which NE contributes to stress-associated salmonellosis is unclear.Salmonella has been proposed to sense and respond to NE via a homologue of the adrenergic sensor kinase QseC.Our data support the notion that stress-related catecholamines modulate the interaction of enteric bacterial pathogens with their hosts.

View Article: PubMed Central - PubMed

Affiliation: Enteric Bacterial Pathogens Laboratory, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom.

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Intravenous administration of 6-OHDA to pigs increases plasma NE levels and faecal excretion of Salmonella Typhimurium. Plasma NE (ng/mL) was quantified by ELISA immediately before and 1 h after treatment with a total of 40 mg/kg 6-OHDA or diluent 7 days post-inoculation with ST4/74 nalR (panel A) or 16 days post-inoculation (panel C). The impact of treatment on the course of faecal excretion is shown for pigs treated at 7 and 16 days post-inoculation in panels B and D, respectively. Values shown are the least square means (LSM) ± standard error (SE) of the LSM. p values ≤ 0.05 are marked with an asterisk. † denotes significant differences in the 6-OHDA group relative to pre-treatment samples.
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Figure 1: Intravenous administration of 6-OHDA to pigs increases plasma NE levels and faecal excretion of Salmonella Typhimurium. Plasma NE (ng/mL) was quantified by ELISA immediately before and 1 h after treatment with a total of 40 mg/kg 6-OHDA or diluent 7 days post-inoculation with ST4/74 nalR (panel A) or 16 days post-inoculation (panel C). The impact of treatment on the course of faecal excretion is shown for pigs treated at 7 and 16 days post-inoculation in panels B and D, respectively. Values shown are the least square means (LSM) ± standard error (SE) of the LSM. p values ≤ 0.05 are marked with an asterisk. † denotes significant differences in the 6-OHDA group relative to pre-treatment samples.


6-hydroxydopamine-mediated release of norepinephrine increases faecal excretion of Salmonella enterica serovar Typhimurium in pigs.

Pullinger GD, van Diemen PM, Carnell SC, Davies H, Lyte M, Stevens MP - Vet. Res. (2010)

Intravenous administration of 6-OHDA to pigs increases plasma NE levels and faecal excretion of Salmonella Typhimurium. Plasma NE (ng/mL) was quantified by ELISA immediately before and 1 h after treatment with a total of 40 mg/kg 6-OHDA or diluent 7 days post-inoculation with ST4/74 nalR (panel A) or 16 days post-inoculation (panel C). The impact of treatment on the course of faecal excretion is shown for pigs treated at 7 and 16 days post-inoculation in panels B and D, respectively. Values shown are the least square means (LSM) ± standard error (SE) of the LSM. p values ≤ 0.05 are marked with an asterisk. † denotes significant differences in the 6-OHDA group relative to pre-treatment samples.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2913729&req=5

Figure 1: Intravenous administration of 6-OHDA to pigs increases plasma NE levels and faecal excretion of Salmonella Typhimurium. Plasma NE (ng/mL) was quantified by ELISA immediately before and 1 h after treatment with a total of 40 mg/kg 6-OHDA or diluent 7 days post-inoculation with ST4/74 nalR (panel A) or 16 days post-inoculation (panel C). The impact of treatment on the course of faecal excretion is shown for pigs treated at 7 and 16 days post-inoculation in panels B and D, respectively. Values shown are the least square means (LSM) ± standard error (SE) of the LSM. p values ≤ 0.05 are marked with an asterisk. † denotes significant differences in the 6-OHDA group relative to pre-treatment samples.
Bottom Line: The stress-related catecholamine norepinephrine (NE) has been reported to activate growth and virulence factor expression in Salmonella; however the extent to which NE contributes to stress-associated salmonellosis is unclear.Salmonella has been proposed to sense and respond to NE via a homologue of the adrenergic sensor kinase QseC.Our data support the notion that stress-related catecholamines modulate the interaction of enteric bacterial pathogens with their hosts.

View Article: PubMed Central - PubMed

Affiliation: Enteric Bacterial Pathogens Laboratory, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom.

Show MeSH
Related in: MedlinePlus