Limits...
Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes.

Zanias S, Papaefstathiou GS, Raptopoulou CP, Papazisis KT, Vala V, Zambouli D, Kortsaris AH, Kyriakidis DA, Zafiropoulos TF - Bioinorg Chem Appl (2010)

Bottom Line: As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated.Reaction of btaH or btd with GaBr(3) or GaCl(3) resulted in the mononuclear complexes [GaBr(3)(btaH)(2)] (1) and [GaCl(3)(btd)(2)] (2), respectively, while treatment of GaCl(3) with L resulted in the anionic complex (LH)(2)[GaCl(4)] (3).All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Patras, 265 04 Patras, Greece.

ABSTRACT
As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr(3) or GaCl(3) resulted in the mononuclear complexes [GaBr(3)(btaH)(2)] (1) and [GaCl(3)(btd)(2)] (2), respectively, while treatment of GaCl(3) with L resulted in the anionic complex (LH)(2)[GaCl(4)] (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.

No MeSH data available.


Related in: MedlinePlus

Dose-effect plots of complex 2 against a panel of human and mouse cancer cell lines 24 h after the administration of the agents. Cytotoxicity was estimated via SRB assay (each point represents a mean of six replicate wells).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2913727&req=5

fig8: Dose-effect plots of complex 2 against a panel of human and mouse cancer cell lines 24 h after the administration of the agents. Cytotoxicity was estimated via SRB assay (each point represents a mean of six replicate wells).

Mentions: Complexes 1 (Figure 7) and 2 (Figure 8) had no significant inhibition on cellular proliferation against HeLa, HT29 and OAW-42 cancer cell lines and a small effect against L929 normal fibroblastic cell line. In contrast, complex 3 inhibited cellular growth of all cell lines, with IC50 concentrations varying between 75 and 125 μM (Figure 9).


Synthesis, Structure, and Antiproliferative Activity of Three Gallium(III) Azole Complexes.

Zanias S, Papaefstathiou GS, Raptopoulou CP, Papazisis KT, Vala V, Zambouli D, Kortsaris AH, Kyriakidis DA, Zafiropoulos TF - Bioinorg Chem Appl (2010)

Dose-effect plots of complex 2 against a panel of human and mouse cancer cell lines 24 h after the administration of the agents. Cytotoxicity was estimated via SRB assay (each point represents a mean of six replicate wells).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2913727&req=5

fig8: Dose-effect plots of complex 2 against a panel of human and mouse cancer cell lines 24 h after the administration of the agents. Cytotoxicity was estimated via SRB assay (each point represents a mean of six replicate wells).
Mentions: Complexes 1 (Figure 7) and 2 (Figure 8) had no significant inhibition on cellular proliferation against HeLa, HT29 and OAW-42 cancer cell lines and a small effect against L929 normal fibroblastic cell line. In contrast, complex 3 inhibited cellular growth of all cell lines, with IC50 concentrations varying between 75 and 125 μM (Figure 9).

Bottom Line: As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated.Reaction of btaH or btd with GaBr(3) or GaCl(3) resulted in the mononuclear complexes [GaBr(3)(btaH)(2)] (1) and [GaCl(3)(btd)(2)] (2), respectively, while treatment of GaCl(3) with L resulted in the anionic complex (LH)(2)[GaCl(4)] (3).All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Patras, 265 04 Patras, Greece.

ABSTRACT
As part of our interest into the bioinorganic chemistry of gallium, gallium(III) complexes of the azole ligands 2,1,3-benzothiadiazole (btd), 1,2,3-benzotriazole (btaH), and 1-methyl-4,5-diphenylimidazole (L) have been isolated. Reaction of btaH or btd with GaBr(3) or GaCl(3) resulted in the mononuclear complexes [GaBr(3)(btaH)(2)] (1) and [GaCl(3)(btd)(2)] (2), respectively, while treatment of GaCl(3) with L resulted in the anionic complex (LH)(2)[GaCl(4)] (3). All three complexes were characterized by single-crystal X-ray crystallography and IR spectroscopy, while their antiproliferative activities were investigated against a series of human and mouse cancer cell lines.

No MeSH data available.


Related in: MedlinePlus