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Vaccine effectiveness estimates, 2004-2005 mumps outbreak, England.

Cohen C, White JM, Savage EJ, Glynn JR, Choi Y, Andrews N, Brown D, Ramsay ME - Emerging Infect. Dis. (2007)

Bottom Line: Of these children, 52 (16.7%) had received 1 dose of MMR vaccine, and 97 (31.1%) had received 2 doses.Vaccine effectiveness was 88% (95% confidence interval [CI] 83%-91%) for 1 dose and 95% (95% CI 93%-96%) for 2 doses.The effectiveness of 1 dose declined from 96% (95% CI 81%-99%) in 2-year-olds to 66% (95% CI 30%-83%) in 11- to 12-year-olds, and the effectiveness of 2 doses declined from 99% (95% CI 97%-99.5%) in 5- to 6-year-olds to 86% (95% CI 74%-93%) in 11- to 12-year-olds (p<0.001 for 1 or 2 doses).

View Article: PubMed Central - PubMed

Affiliation: National Institute for Communicable Diseases, Johannesburg, South Africa. cherylc@nicd.ac.za

ABSTRACT
The United Kingdom and United States have recently experienced large outbreaks of mumps, which raises concerns about vaccine effectiveness. The effectiveness of the mumps component of the measles, mumps, rubella (MMR) vaccine was estimated using the screening method. In England from January 2004 through March 2005, 312 cases of mumps were reported in children eligible to have received 2 doses of MMR vaccine. Of these children, 52 (16.7%) had received 1 dose of MMR vaccine, and 97 (31.1%) had received 2 doses. Vaccine effectiveness was 88% (95% confidence interval [CI] 83%-91%) for 1 dose and 95% (95% CI 93%-96%) for 2 doses. The effectiveness of 1 dose declined from 96% (95% CI 81%-99%) in 2-year-olds to 66% (95% CI 30%-83%) in 11- to 12-year-olds, and the effectiveness of 2 doses declined from 99% (95% CI 97%-99.5%) in 5- to 6-year-olds to 86% (95% CI 74%-93%) in 11- to 12-year-olds (p<0.001 for 1 or 2 doses). Waning immunity may contribute to mumps outbreaks in older vaccinated populations.

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Estimates of 1-dose vaccine effectiveness for cases in 2004–05, assuming an increase in coverage of 0.04%–0.4% per year of age, which represents vaccination of approximately 1%–10% of unvaccinated persons per year of age. Values are offset on the x-axis so that 95% confidence intervals (CIs) are visible.
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Figure 2: Estimates of 1-dose vaccine effectiveness for cases in 2004–05, assuming an increase in coverage of 0.04%–0.4% per year of age, which represents vaccination of approximately 1%–10% of unvaccinated persons per year of age. Values are offset on the x-axis so that 95% confidence intervals (CIs) are visible.

Mentions: Age at first MMR vaccination was available for 148,525 children registered on the South Thames child health computer system. In each birth cohort, 3–45 children per year received the first MMR dose at >5 years of age, most between 5 and 6 years of age. On average, an additional 0.04% (95% CI 0.036%–0.045%) of children received MMR vaccine per year of age after their fifth birthday. In the sensitivity analysis (Figure 2), a fixed increase in coverage per year of age did not abolish the statistically significant decline in vaccine effectiveness until coverage increased by at least 0.4% per year, 10× greater than that estimated from children in the South Thames region.


Vaccine effectiveness estimates, 2004-2005 mumps outbreak, England.

Cohen C, White JM, Savage EJ, Glynn JR, Choi Y, Andrews N, Brown D, Ramsay ME - Emerging Infect. Dis. (2007)

Estimates of 1-dose vaccine effectiveness for cases in 2004–05, assuming an increase in coverage of 0.04%–0.4% per year of age, which represents vaccination of approximately 1%–10% of unvaccinated persons per year of age. Values are offset on the x-axis so that 95% confidence intervals (CIs) are visible.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2913658&req=5

Figure 2: Estimates of 1-dose vaccine effectiveness for cases in 2004–05, assuming an increase in coverage of 0.04%–0.4% per year of age, which represents vaccination of approximately 1%–10% of unvaccinated persons per year of age. Values are offset on the x-axis so that 95% confidence intervals (CIs) are visible.
Mentions: Age at first MMR vaccination was available for 148,525 children registered on the South Thames child health computer system. In each birth cohort, 3–45 children per year received the first MMR dose at >5 years of age, most between 5 and 6 years of age. On average, an additional 0.04% (95% CI 0.036%–0.045%) of children received MMR vaccine per year of age after their fifth birthday. In the sensitivity analysis (Figure 2), a fixed increase in coverage per year of age did not abolish the statistically significant decline in vaccine effectiveness until coverage increased by at least 0.4% per year, 10× greater than that estimated from children in the South Thames region.

Bottom Line: Of these children, 52 (16.7%) had received 1 dose of MMR vaccine, and 97 (31.1%) had received 2 doses.Vaccine effectiveness was 88% (95% confidence interval [CI] 83%-91%) for 1 dose and 95% (95% CI 93%-96%) for 2 doses.The effectiveness of 1 dose declined from 96% (95% CI 81%-99%) in 2-year-olds to 66% (95% CI 30%-83%) in 11- to 12-year-olds, and the effectiveness of 2 doses declined from 99% (95% CI 97%-99.5%) in 5- to 6-year-olds to 86% (95% CI 74%-93%) in 11- to 12-year-olds (p<0.001 for 1 or 2 doses).

View Article: PubMed Central - PubMed

Affiliation: National Institute for Communicable Diseases, Johannesburg, South Africa. cherylc@nicd.ac.za

ABSTRACT
The United Kingdom and United States have recently experienced large outbreaks of mumps, which raises concerns about vaccine effectiveness. The effectiveness of the mumps component of the measles, mumps, rubella (MMR) vaccine was estimated using the screening method. In England from January 2004 through March 2005, 312 cases of mumps were reported in children eligible to have received 2 doses of MMR vaccine. Of these children, 52 (16.7%) had received 1 dose of MMR vaccine, and 97 (31.1%) had received 2 doses. Vaccine effectiveness was 88% (95% confidence interval [CI] 83%-91%) for 1 dose and 95% (95% CI 93%-96%) for 2 doses. The effectiveness of 1 dose declined from 96% (95% CI 81%-99%) in 2-year-olds to 66% (95% CI 30%-83%) in 11- to 12-year-olds, and the effectiveness of 2 doses declined from 99% (95% CI 97%-99.5%) in 5- to 6-year-olds to 86% (95% CI 74%-93%) in 11- to 12-year-olds (p<0.001 for 1 or 2 doses). Waning immunity may contribute to mumps outbreaks in older vaccinated populations.

Show MeSH
Related in: MedlinePlus