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Bipolar disorder associated with tuberous sclerosis: Chance association or aetiological relationship?

Chopra VK, Cintury Y, Sinha VK - Indian J Psychiatry (2006)

Bottom Line: Mental retardation, epilepsy, autism and hyperactivity are commonly reported neuropsychiatric disorders associated with tuberous sclerosis.Rarely, other psychiatric disorders such as psychosis, depression and anxiety associated with this condition have been reported in the literature.A case of bipolar disorder associated with tuberous sclerosis with onset of the first manic episode at the age of 7 years is reported.

View Article: PubMed Central - PubMed

Affiliation: Senior Resident.

ABSTRACT
Tuberous sclerosis is a rare disorder. Mental retardation, epilepsy, autism and hyperactivity are commonly reported neuropsychiatric disorders associated with tuberous sclerosis. Rarely, other psychiatric disorders such as psychosis, depression and anxiety associated with this condition have been reported in the literature. A case of bipolar disorder associated with tuberous sclerosis with onset of the first manic episode at the age of 7 years is reported. The possibility of tuberous sclerosis as one of the causes of secondary mood disorder in very young children is also discussed.

No MeSH data available.


Related in: MedlinePlus

CT scan showing multiple subependymal nodules along the walls of the lateral ventricles. Cortical tubers are seen in the posterior fossa.
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Figure 0002: CT scan showing multiple subependymal nodules along the walls of the lateral ventricles. Cortical tubers are seen in the posterior fossa.

Mentions: A diagnosis of bipolar affective disorder—third episode, currently mania with psychotic features with tuberous sclerosis was made. The patient was put on 3 mg of risperidone and 400 mg of sodium valproate, which was raised to 600 mg per day. She was treated as an outpatient and was doing well on this regimen when seen 2 months after the initial presentation. During follow-up visits, an IQ assessment and a CT scan were done. IQ assessment showed a composite IQ of 102 which showed that she had average intelligence. CT scan findings (Fig. 2) showed multiple subependymal nodules present typically along the walls of the lateral ventricles. Cortical tubers were seen in the posterior fossa. Thus, the physical findings of adenomae sebaceum and CT findings confirmed the diagnosis of tuberous sclerosis. An EEG showed sharp and slow wave discharges on the right side with a preponderance in the frontotemporal region.


Bipolar disorder associated with tuberous sclerosis: Chance association or aetiological relationship?

Chopra VK, Cintury Y, Sinha VK - Indian J Psychiatry (2006)

CT scan showing multiple subependymal nodules along the walls of the lateral ventricles. Cortical tubers are seen in the posterior fossa.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2913649&req=5

Figure 0002: CT scan showing multiple subependymal nodules along the walls of the lateral ventricles. Cortical tubers are seen in the posterior fossa.
Mentions: A diagnosis of bipolar affective disorder—third episode, currently mania with psychotic features with tuberous sclerosis was made. The patient was put on 3 mg of risperidone and 400 mg of sodium valproate, which was raised to 600 mg per day. She was treated as an outpatient and was doing well on this regimen when seen 2 months after the initial presentation. During follow-up visits, an IQ assessment and a CT scan were done. IQ assessment showed a composite IQ of 102 which showed that she had average intelligence. CT scan findings (Fig. 2) showed multiple subependymal nodules present typically along the walls of the lateral ventricles. Cortical tubers were seen in the posterior fossa. Thus, the physical findings of adenomae sebaceum and CT findings confirmed the diagnosis of tuberous sclerosis. An EEG showed sharp and slow wave discharges on the right side with a preponderance in the frontotemporal region.

Bottom Line: Mental retardation, epilepsy, autism and hyperactivity are commonly reported neuropsychiatric disorders associated with tuberous sclerosis.Rarely, other psychiatric disorders such as psychosis, depression and anxiety associated with this condition have been reported in the literature.A case of bipolar disorder associated with tuberous sclerosis with onset of the first manic episode at the age of 7 years is reported.

View Article: PubMed Central - PubMed

Affiliation: Senior Resident.

ABSTRACT
Tuberous sclerosis is a rare disorder. Mental retardation, epilepsy, autism and hyperactivity are commonly reported neuropsychiatric disorders associated with tuberous sclerosis. Rarely, other psychiatric disorders such as psychosis, depression and anxiety associated with this condition have been reported in the literature. A case of bipolar disorder associated with tuberous sclerosis with onset of the first manic episode at the age of 7 years is reported. The possibility of tuberous sclerosis as one of the causes of secondary mood disorder in very young children is also discussed.

No MeSH data available.


Related in: MedlinePlus