Limits...
Dynamic pupillary exchange engages brain regions encoding social salience.

Harrison NA, Gray MA, Critchley HD - Soc Neurosci (2008)

Bottom Line: Discordance between observed and observer's pupillary changes enhanced activity within bilateral anterior insula, left amygdala and anterior cingulate.Our findings suggest pupillary signals are monitored continuously during social interactions and that incongruent changes activate brain regions involved in tracking motivational salience and attentionally meaningful information.Our data provide empirical evidence for an autonomically mediated extension of forward models of motor control into social interaction.

View Article: PubMed Central - PubMed

Affiliation: University College London, London, UK. n.harrison@fil.ion.ucl.ac.uk

ABSTRACT
Covert exchange of autonomic responses may shape social affective behavior, as observed in mirroring of pupillary responses during sadness processing. We examined how, independent of facial emotional expression, dynamic coherence between one's own and another's pupil size modulates regional brain activity. Fourteen subjects viewed pairs of eye stimuli while undergoing fMRI. Using continuous pupillometry biofeedback, the size of the observed pupils was varied, correlating positively or negatively with changes in participants' own pupils. Viewing both static and dynamic stimuli activated right fusiform gyrus. Observing dynamically changing pupils activated STS and amygdala, regions engaged by non-static and salient facial features. Discordance between observed and observer's pupillary changes enhanced activity within bilateral anterior insula, left amygdala and anterior cingulate. In contrast, processing positively correlated pupils enhanced activity within left frontal operculum. Our findings suggest pupillary signals are monitored continuously during social interactions and that incongruent changes activate brain regions involved in tracking motivational salience and attentionally meaningful information. Naturalistically, dynamic coherence in pupillary change follows fluctuations in ambient light. Correspondingly, in social contexts discordant pupil response is likely to reflect divergence of dispositional state. Our data provide empirical evidence for an autonomically mediated extension of forward models of motor control into social interaction.

Show MeSH

Related in: MedlinePlus

Interaction between feedback condition and variance in pupil size showing significant activation in: (A) anterior cingulated; (B) left amygdala; (C) bilateral anterior insula for negative positive feedback. Activations plotted at p =.05 for illustration, only clusters of 50 or more voxels shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2913324&req=5

Figure 4: Interaction between feedback condition and variance in pupil size showing significant activation in: (A) anterior cingulated; (B) left amygdala; (C) bilateral anterior insula for negative positive feedback. Activations plotted at p =.05 for illustration, only clusters of 50 or more voxels shown.

Mentions: We also examined the context-specific engagement of different brain systems by positive and negative feedback by testing for an interaction between feedback condition (coherent or incoher ent) and the magnitude of change in observed pupil size. Pupil change in the positive feedback condition was associated with increasing activity within right precentral gyrus, right frontal operculum and mid cingulate cortex (see Table 3). Region-of-interest analysis revealed no significant activation within superior temporal sulcus (STS), insula or amygdala. Pupil change during the negative (incoherent) feedback conditions, where the observed pupils reacted in a directly opposite manner to the participant's own pupils, was also associated with mid cingulate activation. However, in contrast to the coherent feedback condition, there was additional activation in the left amygdala and bilateral anterior insula, regions implicated in social and emotional processing (see Figure 4).


Dynamic pupillary exchange engages brain regions encoding social salience.

Harrison NA, Gray MA, Critchley HD - Soc Neurosci (2008)

Interaction between feedback condition and variance in pupil size showing significant activation in: (A) anterior cingulated; (B) left amygdala; (C) bilateral anterior insula for negative positive feedback. Activations plotted at p =.05 for illustration, only clusters of 50 or more voxels shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2913324&req=5

Figure 4: Interaction between feedback condition and variance in pupil size showing significant activation in: (A) anterior cingulated; (B) left amygdala; (C) bilateral anterior insula for negative positive feedback. Activations plotted at p =.05 for illustration, only clusters of 50 or more voxels shown.
Mentions: We also examined the context-specific engagement of different brain systems by positive and negative feedback by testing for an interaction between feedback condition (coherent or incoher ent) and the magnitude of change in observed pupil size. Pupil change in the positive feedback condition was associated with increasing activity within right precentral gyrus, right frontal operculum and mid cingulate cortex (see Table 3). Region-of-interest analysis revealed no significant activation within superior temporal sulcus (STS), insula or amygdala. Pupil change during the negative (incoherent) feedback conditions, where the observed pupils reacted in a directly opposite manner to the participant's own pupils, was also associated with mid cingulate activation. However, in contrast to the coherent feedback condition, there was additional activation in the left amygdala and bilateral anterior insula, regions implicated in social and emotional processing (see Figure 4).

Bottom Line: Discordance between observed and observer's pupillary changes enhanced activity within bilateral anterior insula, left amygdala and anterior cingulate.Our findings suggest pupillary signals are monitored continuously during social interactions and that incongruent changes activate brain regions involved in tracking motivational salience and attentionally meaningful information.Our data provide empirical evidence for an autonomically mediated extension of forward models of motor control into social interaction.

View Article: PubMed Central - PubMed

Affiliation: University College London, London, UK. n.harrison@fil.ion.ucl.ac.uk

ABSTRACT
Covert exchange of autonomic responses may shape social affective behavior, as observed in mirroring of pupillary responses during sadness processing. We examined how, independent of facial emotional expression, dynamic coherence between one's own and another's pupil size modulates regional brain activity. Fourteen subjects viewed pairs of eye stimuli while undergoing fMRI. Using continuous pupillometry biofeedback, the size of the observed pupils was varied, correlating positively or negatively with changes in participants' own pupils. Viewing both static and dynamic stimuli activated right fusiform gyrus. Observing dynamically changing pupils activated STS and amygdala, regions engaged by non-static and salient facial features. Discordance between observed and observer's pupillary changes enhanced activity within bilateral anterior insula, left amygdala and anterior cingulate. In contrast, processing positively correlated pupils enhanced activity within left frontal operculum. Our findings suggest pupillary signals are monitored continuously during social interactions and that incongruent changes activate brain regions involved in tracking motivational salience and attentionally meaningful information. Naturalistically, dynamic coherence in pupillary change follows fluctuations in ambient light. Correspondingly, in social contexts discordant pupil response is likely to reflect divergence of dispositional state. Our data provide empirical evidence for an autonomically mediated extension of forward models of motor control into social interaction.

Show MeSH
Related in: MedlinePlus