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Prevalence and predictors of overweight and insulin resistance in offspring of mothers with gestational diabetes mellitus.

Boerschmann H, Pflüger M, Henneberger L, Ziegler AG, Hummel S - Diabetes Care (2010)

Bottom Line: Maternal obesity was an important predictor of overweight risk in children (age 11 years odds ratio 7.0 [95% CI 1.8-27.7]; P = 0.006); birth size and maternal smoking during pregnancy were inconsistently associated with and treatment of GDM during pregnancy did not affect overweight risk.HOMA-IR was increased in OGDM compared with offspring of ONDM mothers (P = 0.01, adjusted for sex and age) and was associated with the child's BMI (P = 0.004).The finding that overweight risk is associated mainly with maternal obesity suggests that familial predisposition contributes to childhood growth in these offspring.

View Article: PubMed Central - PubMed

Affiliation: Forschergruppe Diabetes der Technischen Universität München, Munich, Germany.

ABSTRACT

Objective: Gestational diabetes mellitus (GDM) is associated with high birth weight in the offspring. This may lead to overweight and insulin resistance during childhood. The aim of the study was to assess the impact of GDM on overweight risk and insulin resistance in offspring.

Research design and methods: BMI measurements were collected at age 2, 8, and 11 years from 232 offspring of mothers with GDM (OGDM) and compared with those from 757 offspring of mothers with type 1 diabetes (OT1D) and 431 offspring of nondiabetic mothers (ONDM) born between 1989 and 2000. Insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]) was determined at age 8 and 11 years in 751 children (74 OGDM). Overweight was defined as BMI percentile >or=90; insulin resistance was defined by HOMA-IR.

Results: Overweight prevalence was increased in OGDM compared with OT1D and to ONDM throughout childhood (age 11 years 31.1, 15.8, and 15.5%; P = 0.005). Maternal obesity was an important predictor of overweight risk in children (age 11 years odds ratio 7.0 [95% CI 1.8-27.7]; P = 0.006); birth size and maternal smoking during pregnancy were inconsistently associated with and treatment of GDM during pregnancy did not affect overweight risk. HOMA-IR was increased in OGDM compared with offspring of ONDM mothers (P = 0.01, adjusted for sex and age) and was associated with the child's BMI (P = 0.004).

Conclusions: Overweight and insulin resistance in children is increased in OGDM compared with OT1D or ONDM. The finding that overweight risk is associated mainly with maternal obesity suggests that familial predisposition contributes to childhood growth in these offspring.

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Prevalence of overweight at 2, 8, and 11 years of age in OGDM (■), OT1D (), and ONDM (□).
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Figure 1: Prevalence of overweight at 2, 8, and 11 years of age in OGDM (■), OT1D (), and ONDM (□).

Mentions: Prevalence of overweight in OGDM was 17.2% at age 2 years, 20.2% at age 8 years, and 31.1% at age 11 years. Prevalence of overweight was increased in OGDM compared with OT1D (15.8, 11.0, and 15.8% at age 2, 8, and 11 years, respectively; P < 0.05, P = 0.03, and P < 0.01, respectively) and with ONDM (11.4, 10.3, and 15.5%; P = 0.7, P = 0.02, and P = 0.005, respectively (Fig. 1).


Prevalence and predictors of overweight and insulin resistance in offspring of mothers with gestational diabetes mellitus.

Boerschmann H, Pflüger M, Henneberger L, Ziegler AG, Hummel S - Diabetes Care (2010)

Prevalence of overweight at 2, 8, and 11 years of age in OGDM (■), OT1D (), and ONDM (□).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2909075&req=5

Figure 1: Prevalence of overweight at 2, 8, and 11 years of age in OGDM (■), OT1D (), and ONDM (□).
Mentions: Prevalence of overweight in OGDM was 17.2% at age 2 years, 20.2% at age 8 years, and 31.1% at age 11 years. Prevalence of overweight was increased in OGDM compared with OT1D (15.8, 11.0, and 15.8% at age 2, 8, and 11 years, respectively; P < 0.05, P = 0.03, and P < 0.01, respectively) and with ONDM (11.4, 10.3, and 15.5%; P = 0.7, P = 0.02, and P = 0.005, respectively (Fig. 1).

Bottom Line: Maternal obesity was an important predictor of overweight risk in children (age 11 years odds ratio 7.0 [95% CI 1.8-27.7]; P = 0.006); birth size and maternal smoking during pregnancy were inconsistently associated with and treatment of GDM during pregnancy did not affect overweight risk.HOMA-IR was increased in OGDM compared with offspring of ONDM mothers (P = 0.01, adjusted for sex and age) and was associated with the child's BMI (P = 0.004).The finding that overweight risk is associated mainly with maternal obesity suggests that familial predisposition contributes to childhood growth in these offspring.

View Article: PubMed Central - PubMed

Affiliation: Forschergruppe Diabetes der Technischen Universität München, Munich, Germany.

ABSTRACT

Objective: Gestational diabetes mellitus (GDM) is associated with high birth weight in the offspring. This may lead to overweight and insulin resistance during childhood. The aim of the study was to assess the impact of GDM on overweight risk and insulin resistance in offspring.

Research design and methods: BMI measurements were collected at age 2, 8, and 11 years from 232 offspring of mothers with GDM (OGDM) and compared with those from 757 offspring of mothers with type 1 diabetes (OT1D) and 431 offspring of nondiabetic mothers (ONDM) born between 1989 and 2000. Insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]) was determined at age 8 and 11 years in 751 children (74 OGDM). Overweight was defined as BMI percentile >or=90; insulin resistance was defined by HOMA-IR.

Results: Overweight prevalence was increased in OGDM compared with OT1D and to ONDM throughout childhood (age 11 years 31.1, 15.8, and 15.5%; P = 0.005). Maternal obesity was an important predictor of overweight risk in children (age 11 years odds ratio 7.0 [95% CI 1.8-27.7]; P = 0.006); birth size and maternal smoking during pregnancy were inconsistently associated with and treatment of GDM during pregnancy did not affect overweight risk. HOMA-IR was increased in OGDM compared with offspring of ONDM mothers (P = 0.01, adjusted for sex and age) and was associated with the child's BMI (P = 0.004).

Conclusions: Overweight and insulin resistance in children is increased in OGDM compared with OT1D or ONDM. The finding that overweight risk is associated mainly with maternal obesity suggests that familial predisposition contributes to childhood growth in these offspring.

Show MeSH
Related in: MedlinePlus