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Mixing insulin aspart with detemir does not affect glucose excursion in children with type 1 diabetes.

Nguyen TM, Renukuntla VS, Heptulla RA - Diabetes Care (2010)

Bottom Line: Each subject underwent continuous glucose monitoring on the last 72 h of each study.The 48-h area under the curve (mmol/hour/l), M-value, and mean amplitude of glucose excursion (mmol/l) for Study A versus Study B were 457 +/- 70 versus 469 +/- 112 (P = 0.58), 39.67 +/- 15.37 versus 39.75 +/- 9.69 (P = 0.98), and 6.35 +/- 1.92 versus 5.98 +/- 0.92 (P = 0.42), respectively.Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics-Endocrinology Section, Nemours Children's Clinic, Jacksonville, Florida, USA.

ABSTRACT

Objective: We hypothesized that insulin detemir mixed with aspart had equivalent effects on blood glucose as if being given as separate injections in pediatric type 1 diabetes patients.

Research design and methods: Fourteen children with type 1 diabetes were randomly assigned to either Study A (mixed insulins) or Study B (separate insulins) for the first 10 days and crossed over for the last 10 days. Each subject underwent continuous glucose monitoring on the last 72 h of each study.

Results: The 48-h area under the curve (mmol/hour/l), M-value, and mean amplitude of glucose excursion (mmol/l) for Study A versus Study B were 457 +/- 70 versus 469 +/- 112 (P = 0.58), 39.67 +/- 15.37 versus 39.75 +/- 9.69 (P = 0.98), and 6.35 +/- 1.92 versus 5.98 +/- 0.92 (P = 0.42), respectively.

Conclusions: Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.

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Related in: MedlinePlus

The 48-h CGM tracings for each subject taking detemir separately from aspart (gray lines) and detemir mixed with aspart (black lines).
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Figure 1: The 48-h CGM tracings for each subject taking detemir separately from aspart (gray lines) and detemir mixed with aspart (black lines).

Mentions: Fourteen subjects completed this 20-day, randomized, crossover, open-labeled study. One male subject dropped out because of a very active sports schedule and could not continue participation. Three subjects (two males and one female) had trouble with the CGM tracing and, therefore, were excluded from the final analysis. Figure 1 shows 48-h CGM tracing for 14 subjects. AUC was 457 ± 70 mmol/hour/l for Study A compared with 469 ± 112 mmol/hour/l for Study B (P = 0.58). The M-value was 39.67 ± 15.37 for Study A compared with 39.75 ± 9.69 for Study B (P = 0.98). MAGE was 6.35 ± 1.92 mmol/l for Study A compared with 5.98 ± 0.92 mmol/l for Study B (P = 0.42). Relative frequency of mild hypoglycemic episodes was 5.3 ± 5.2% for Study A versus 6.7 ± 11.1% for Study B (P = 0.95). There was no severe hypoglycemia in either group.


Mixing insulin aspart with detemir does not affect glucose excursion in children with type 1 diabetes.

Nguyen TM, Renukuntla VS, Heptulla RA - Diabetes Care (2010)

The 48-h CGM tracings for each subject taking detemir separately from aspart (gray lines) and detemir mixed with aspart (black lines).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2909056&req=5

Figure 1: The 48-h CGM tracings for each subject taking detemir separately from aspart (gray lines) and detemir mixed with aspart (black lines).
Mentions: Fourteen subjects completed this 20-day, randomized, crossover, open-labeled study. One male subject dropped out because of a very active sports schedule and could not continue participation. Three subjects (two males and one female) had trouble with the CGM tracing and, therefore, were excluded from the final analysis. Figure 1 shows 48-h CGM tracing for 14 subjects. AUC was 457 ± 70 mmol/hour/l for Study A compared with 469 ± 112 mmol/hour/l for Study B (P = 0.58). The M-value was 39.67 ± 15.37 for Study A compared with 39.75 ± 9.69 for Study B (P = 0.98). MAGE was 6.35 ± 1.92 mmol/l for Study A compared with 5.98 ± 0.92 mmol/l for Study B (P = 0.42). Relative frequency of mild hypoglycemic episodes was 5.3 ± 5.2% for Study A versus 6.7 ± 11.1% for Study B (P = 0.95). There was no severe hypoglycemia in either group.

Bottom Line: Each subject underwent continuous glucose monitoring on the last 72 h of each study.The 48-h area under the curve (mmol/hour/l), M-value, and mean amplitude of glucose excursion (mmol/l) for Study A versus Study B were 457 +/- 70 versus 469 +/- 112 (P = 0.58), 39.67 +/- 15.37 versus 39.75 +/- 9.69 (P = 0.98), and 6.35 +/- 1.92 versus 5.98 +/- 0.92 (P = 0.42), respectively.Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics-Endocrinology Section, Nemours Children's Clinic, Jacksonville, Florida, USA.

ABSTRACT

Objective: We hypothesized that insulin detemir mixed with aspart had equivalent effects on blood glucose as if being given as separate injections in pediatric type 1 diabetes patients.

Research design and methods: Fourteen children with type 1 diabetes were randomly assigned to either Study A (mixed insulins) or Study B (separate insulins) for the first 10 days and crossed over for the last 10 days. Each subject underwent continuous glucose monitoring on the last 72 h of each study.

Results: The 48-h area under the curve (mmol/hour/l), M-value, and mean amplitude of glucose excursion (mmol/l) for Study A versus Study B were 457 +/- 70 versus 469 +/- 112 (P = 0.58), 39.67 +/- 15.37 versus 39.75 +/- 9.69 (P = 0.98), and 6.35 +/- 1.92 versus 5.98 +/- 0.92 (P = 0.42), respectively.

Conclusions: Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.

Show MeSH
Related in: MedlinePlus