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Thickness changes in the fovea and peripapillary retinal nerve fiber layer depend on the degree of myopia.

Choi SW, Lee SJ - Korean J Ophthalmol (2006)

Bottom Line: The data showed significant differences in fovea thickness between the groups.The average thicknesses of the peripapillary RNFL for each of three groups were 113.29 +/- 10.80 microm in group one, 103.85 +/- 14.48 microm in group two and 100.74 +/- 9.15 microm in group three.A statistically significant difference was found between group one and the other groups (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Wonju Christian Hospital, Yonsei University, Wonju College of Medicine, Wonju, Korea.

ABSTRACT

Purpose: To investigate changes in the thickness of the fovea and peripapillary RNFL associated with myopia.

Methods: Sixty-five Korean adults (for a total of 130 eyes) between 23 and 26 years of age were selected as test subjects. Thirty-eight test subjects were male, and 27 were female. Subjects with glaucoma or other identified ocular diseases were excluded. Patients whose manifest refraction measurement values ranged between 0 to -2D were classified as group one (emmetropia and low myopia), those between -2 to -5D were classified as group two (moderate myopia), and those more than -5D were classified as group three (high myopia). Using the OCT, the thickness of the fovea and peripapillary RNFL were measured for every subject.

Results: The thicknesses of the fovea for each of three groups were 142.16 +/- 8.99 microm in group one (45 eyes), 153.58 +/- 17.63 microm in group two (43 eyes) and 158.86 +/- 11.93 microm in group three (28 eyes). The data showed significant differences in fovea thickness between the groups. The average thicknesses of the peripapillary RNFL for each of three groups were 113.29 +/- 10.80 microm in group one, 103.85 +/- 14.48 microm in group two and 100.74 +/- 9.15 microm in group three. A statistically significant difference was found between group one and the other groups (p < 0.05).

Conclusions: As the level of myopia increased, the thickness of the fovea also increased, while the thickness of the peripapillary RNFL decreased. Therefore, when interpreting OCT results in the clinic, careful consideration should be given to various changes associated with myopia.

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Relationship between RNFL-nasal thickness and myopia.
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Figure 6: Relationship between RNFL-nasal thickness and myopia.

Mentions: The average of the spherical equivalents was -0.34±0.63 D in group one (45 eyes, 38.8%), -3.88±0.85 D in group two (43 eyes, 37.1%), and -6.85±1.32 D in group three (28 eyes, 24.1%). The range was 0 to -9.25. The average axial length was 24.46±1.00 mm (range, 22.31 to 26.40 mm). The spherical equivalents, axial lengths, and thickness values for the fovea and the peripapillary RNFL are shown in Table 1. In all three groups, there were significant differences in axial length and in the thickness of the inferior RNFL. As for the foveal thickness, group one showed the thinnest thickness in the average, superior and nasal RNFL compared to the other groups. However, for all three groups, there were no significant differences in the thickness of the temporal RNFL. As myopia increased, changes in other parameters were evaluated by simple regression analysis. The axial length of the eye became longer (P<0.001; Fig. 1), and the thickness of the fovea significantly increased (P<0.001; Fig. 2). Conversely, the thickness of the average, superior, inferior and nasal RNFL decreased (P<0.001; Figs. 3, 4, 5, 6). There was no correlation between myopia and thickness of the temporal RNFL (P=0.236; Fig. 7).


Thickness changes in the fovea and peripapillary retinal nerve fiber layer depend on the degree of myopia.

Choi SW, Lee SJ - Korean J Ophthalmol (2006)

Relationship between RNFL-nasal thickness and myopia.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908854&req=5

Figure 6: Relationship between RNFL-nasal thickness and myopia.
Mentions: The average of the spherical equivalents was -0.34±0.63 D in group one (45 eyes, 38.8%), -3.88±0.85 D in group two (43 eyes, 37.1%), and -6.85±1.32 D in group three (28 eyes, 24.1%). The range was 0 to -9.25. The average axial length was 24.46±1.00 mm (range, 22.31 to 26.40 mm). The spherical equivalents, axial lengths, and thickness values for the fovea and the peripapillary RNFL are shown in Table 1. In all three groups, there were significant differences in axial length and in the thickness of the inferior RNFL. As for the foveal thickness, group one showed the thinnest thickness in the average, superior and nasal RNFL compared to the other groups. However, for all three groups, there were no significant differences in the thickness of the temporal RNFL. As myopia increased, changes in other parameters were evaluated by simple regression analysis. The axial length of the eye became longer (P<0.001; Fig. 1), and the thickness of the fovea significantly increased (P<0.001; Fig. 2). Conversely, the thickness of the average, superior, inferior and nasal RNFL decreased (P<0.001; Figs. 3, 4, 5, 6). There was no correlation between myopia and thickness of the temporal RNFL (P=0.236; Fig. 7).

Bottom Line: The data showed significant differences in fovea thickness between the groups.The average thicknesses of the peripapillary RNFL for each of three groups were 113.29 +/- 10.80 microm in group one, 103.85 +/- 14.48 microm in group two and 100.74 +/- 9.15 microm in group three.A statistically significant difference was found between group one and the other groups (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Wonju Christian Hospital, Yonsei University, Wonju College of Medicine, Wonju, Korea.

ABSTRACT

Purpose: To investigate changes in the thickness of the fovea and peripapillary RNFL associated with myopia.

Methods: Sixty-five Korean adults (for a total of 130 eyes) between 23 and 26 years of age were selected as test subjects. Thirty-eight test subjects were male, and 27 were female. Subjects with glaucoma or other identified ocular diseases were excluded. Patients whose manifest refraction measurement values ranged between 0 to -2D were classified as group one (emmetropia and low myopia), those between -2 to -5D were classified as group two (moderate myopia), and those more than -5D were classified as group three (high myopia). Using the OCT, the thickness of the fovea and peripapillary RNFL were measured for every subject.

Results: The thicknesses of the fovea for each of three groups were 142.16 +/- 8.99 microm in group one (45 eyes), 153.58 +/- 17.63 microm in group two (43 eyes) and 158.86 +/- 11.93 microm in group three (28 eyes). The data showed significant differences in fovea thickness between the groups. The average thicknesses of the peripapillary RNFL for each of three groups were 113.29 +/- 10.80 microm in group one, 103.85 +/- 14.48 microm in group two and 100.74 +/- 9.15 microm in group three. A statistically significant difference was found between group one and the other groups (p < 0.05).

Conclusions: As the level of myopia increased, the thickness of the fovea also increased, while the thickness of the peripapillary RNFL decreased. Therefore, when interpreting OCT results in the clinic, careful consideration should be given to various changes associated with myopia.

Show MeSH
Related in: MedlinePlus