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Intravitreal versus posterior subtenon injection of triamcinolone acetonide for diabetic macular edema.

Choi YJ, Oh IK, Oh JR, Huh K - Korean J Ophthalmol (2006)

Bottom Line: Visual acuity and intraocular pressure (IOP) were also measured.Both groups resulted in a significant decrease in central macular thickness (CMT) at 1 month and 3 months post-injection.The posterior subtenon injection of triamcinolone acetonide had a comparable effect to the intravitreal triamcinolone injection and showed a lower risk of elevated IOP.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To compare the short-term effects of intravitreal versus posterior subtenon injection of triamcinolone acetonide for diabetic macular edema.

Methods: This is a prospective and interventional study. Sixty eyes of 60 patients who had diffuse diabetic macular edema were assigned to receive a single intravitreal injection (4 mg) or a single posterior subtenon injection (40 mg) of triamcinolone acetonide. The central retinal thickness was measured using optical coherent tomography before injection and at 1 and 3 months after injection. Visual acuity and intraocular pressure (IOP) were also measured.

Results: Both intravitreal and posterior subtenon injections of triamcinolone acetonide resulted in significant improvements in visual acuity at 1 month and 3 months after injection. Both groups resulted in a significant decrease in central macular thickness (CMT) at 1 month and 3 months post-injection. IOP in the intravitreal injection group was significantly higher than in the posterior subtenon injection group at 3 months after injection.

Conclusions: The posterior subtenon injection of triamcinolone acetonide had a comparable effect to the intravitreal triamcinolone injection and showed a lower risk of elevated IOP. Posterior subtenon injection of triamcinolone acetonide may be a good alternative for the treatment of diffuse diabetic macular edema.

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Related in: MedlinePlus

Central macular thickness in the intravitreal and posterior subtenon injected eyes at baseline and at 1 and 3 months after triamcinolone acetonide injection.
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Figure 2: Central macular thickness in the intravitreal and posterior subtenon injected eyes at baseline and at 1 and 3 months after triamcinolone acetonide injection.

Mentions: The mean baseline CMT was not significantly different between the 2 groups (p=0.461). In both the intravitreal and posterior subtenon injection group, the CMT was significantly decreased through the study (Table 3, Fig. 2). At 3 months after injection, OCT demonstrated a reduction of the mean CMT (intravitreal group: 46.2%, subtenon group: 43.5%). Between the 2 groups, there was no significant difference in the mean CMT change before injection or at 1 month and 3 months after injection. Fig. 3 illustrates the changes in the OCT images of a representative patient in the intravitreal injection group and of a patient in the posterior subtenon injection group.


Intravitreal versus posterior subtenon injection of triamcinolone acetonide for diabetic macular edema.

Choi YJ, Oh IK, Oh JR, Huh K - Korean J Ophthalmol (2006)

Central macular thickness in the intravitreal and posterior subtenon injected eyes at baseline and at 1 and 3 months after triamcinolone acetonide injection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908852&req=5

Figure 2: Central macular thickness in the intravitreal and posterior subtenon injected eyes at baseline and at 1 and 3 months after triamcinolone acetonide injection.
Mentions: The mean baseline CMT was not significantly different between the 2 groups (p=0.461). In both the intravitreal and posterior subtenon injection group, the CMT was significantly decreased through the study (Table 3, Fig. 2). At 3 months after injection, OCT demonstrated a reduction of the mean CMT (intravitreal group: 46.2%, subtenon group: 43.5%). Between the 2 groups, there was no significant difference in the mean CMT change before injection or at 1 month and 3 months after injection. Fig. 3 illustrates the changes in the OCT images of a representative patient in the intravitreal injection group and of a patient in the posterior subtenon injection group.

Bottom Line: Visual acuity and intraocular pressure (IOP) were also measured.Both groups resulted in a significant decrease in central macular thickness (CMT) at 1 month and 3 months post-injection.The posterior subtenon injection of triamcinolone acetonide had a comparable effect to the intravitreal triamcinolone injection and showed a lower risk of elevated IOP.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To compare the short-term effects of intravitreal versus posterior subtenon injection of triamcinolone acetonide for diabetic macular edema.

Methods: This is a prospective and interventional study. Sixty eyes of 60 patients who had diffuse diabetic macular edema were assigned to receive a single intravitreal injection (4 mg) or a single posterior subtenon injection (40 mg) of triamcinolone acetonide. The central retinal thickness was measured using optical coherent tomography before injection and at 1 and 3 months after injection. Visual acuity and intraocular pressure (IOP) were also measured.

Results: Both intravitreal and posterior subtenon injections of triamcinolone acetonide resulted in significant improvements in visual acuity at 1 month and 3 months after injection. Both groups resulted in a significant decrease in central macular thickness (CMT) at 1 month and 3 months post-injection. IOP in the intravitreal injection group was significantly higher than in the posterior subtenon injection group at 3 months after injection.

Conclusions: The posterior subtenon injection of triamcinolone acetonide had a comparable effect to the intravitreal triamcinolone injection and showed a lower risk of elevated IOP. Posterior subtenon injection of triamcinolone acetonide may be a good alternative for the treatment of diffuse diabetic macular edema.

Show MeSH
Related in: MedlinePlus