Limits...
Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyes.

Min SH, Lee TI, Chung YS, Kim HK - Korean J Ophthalmol (2006)

Bottom Line: Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma.The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method.These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-beta2 levels and levels of the active form of TGF-beta2 in the aqueous humor of eyes with different types of glaucoma.

Methods: The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method.

Results: The levels of total TGF-beta2 in the aqueous samples of POAG, NVG, and SOAG were elevated. The levels of active TGF-beta2 in the aqueous samples of POAG, and NVG were also elevated, whereas the level of active TGF-beta2 was within the normal range in the aqueous samples of SOAG.

Conclusions: These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.

Show MeSH

Related in: MedlinePlus

Concentration of active transforming growth factor (TGF)-β2 in the aqueous humor of different types of glaucoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2908840&req=5

Figure 2: Concentration of active transforming growth factor (TGF)-β2 in the aqueous humor of different types of glaucoma.

Mentions: The concentration of total and active TGF-β2 in each group are shown in Fig. 1 and 2. The concentrations of total TGF-β2 (mean±standard deviation) in the aqueous humor are shown in Fig. 1. The mean concentration of total TGF-β2 in groups P, N, and S was 3824±890 pg/ml, 3264±221 pg/ml, and 1984±539 pg/ml, respectively. These values were significantly higher than that of group C (1392±177 pg/ml, p<0.05).


Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyes.

Min SH, Lee TI, Chung YS, Kim HK - Korean J Ophthalmol (2006)

Concentration of active transforming growth factor (TGF)-β2 in the aqueous humor of different types of glaucoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908840&req=5

Figure 2: Concentration of active transforming growth factor (TGF)-β2 in the aqueous humor of different types of glaucoma.
Mentions: The concentration of total and active TGF-β2 in each group are shown in Fig. 1 and 2. The concentrations of total TGF-β2 (mean±standard deviation) in the aqueous humor are shown in Fig. 1. The mean concentration of total TGF-β2 in groups P, N, and S was 3824±890 pg/ml, 3264±221 pg/ml, and 1984±539 pg/ml, respectively. These values were significantly higher than that of group C (1392±177 pg/ml, p<0.05).

Bottom Line: Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma.The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method.These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-beta2 levels and levels of the active form of TGF-beta2 in the aqueous humor of eyes with different types of glaucoma.

Methods: The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method.

Results: The levels of total TGF-beta2 in the aqueous samples of POAG, NVG, and SOAG were elevated. The levels of active TGF-beta2 in the aqueous samples of POAG, and NVG were also elevated, whereas the level of active TGF-beta2 was within the normal range in the aqueous samples of SOAG.

Conclusions: These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.

Show MeSH
Related in: MedlinePlus